There are several airlines that operate frequent flights from Lisbon (LIS) to Frankfurt (FRA) including

• TAP Portugal with 315 flights a week
• Lufthansa Cargo with 78 flights a week
• Alitalia with 41 flights a week
• Swiss International Air Lines with 25 flights a week
• Brussels Airlines with 21 flights a week

The earliest flight leaves Portela Airport at 05:05 and arrives at Frankfurt Intl. Airport at 09:10. The last flight of the day departs Lisbon at 18:15 and arrives at Frankfurt at 22:25.

The flight distance from Lisbon to Frankfurt is about 1883 km, the shortest flight is 03 hours with Air Europa.

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