S$281 Cheap Flights from Panama City to Mexico City

View S$281 flight on Mon, 23 Feb, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Mexico City

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Cheap Flights from Panama City to Mexico City (PTY-MEX)

Prices were available within the past 7 days and start at S$281 for one-way flights and S$525 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Mon, 23 Feb - Fri, 27 Feb
PTY
Panama City
MEX
Mexico City
S$525 Return, found 5 days ago
S$525
Return
found 5 days ago
Select avianca flight, departing Mon, 23 Feb from Panama City to Mexico City, returning Fri, 27 Feb, priced at S$525 found 5 days ago
avianca
Sat, 21 Feb - Wed, 25 Feb
PTY
Panama City
MEX
Mexico City
S$549 Return, found 5 days ago
S$549
Return
found 5 days ago
Select avianca flight, departing Sat, 21 Feb from Panama City to Mexico City, returning Wed, 25 Feb, priced at S$549 found 5 days ago
avianca
Sat, 21 Feb - Wed, 25 Feb
PTY
Panama City
MEX
Mexico City
S$564 Return, found 5 days ago
S$564
Return
found 5 days ago
Select avianca flight, departing Sat, 21 Feb from Panama City to Mexico City, returning Wed, 25 Feb, priced at S$564 found 5 days ago
Aeromexico
Mon, 23 Feb - Fri, 27 Feb
PTY
Panama City
MEX
Mexico City
S$710 Return, found 5 days ago
S$710
Return
found 5 days ago
Select Aeromexico flight, departing Mon, 23 Feb from Panama City to Mexico City, returning Fri, 27 Feb, priced at S$710 found 5 days ago
Copa
Mon, 23 Feb - Fri, 27 Feb
PTY
Panama City
MEX
Mexico City
S$775 Return, found 5 days ago
S$775
Return
found 5 days ago
Select Copa flight, departing Mon, 23 Feb from Panama City to Mexico City, returning Fri, 27 Feb, priced at S$775 found 5 days ago
Aeromexico
Sat, 21 Feb - Wed, 25 Feb
PTY
Panama City
MEX
Mexico City
S$838 Return, found 5 days ago
S$838
Return
found 5 days ago
Select Aeromexico flight, departing Sat, 21 Feb from Panama City to Mexico City, returning Wed, 25 Feb, priced at S$838 found 5 days ago
American Airlines
Mon, 23 Feb - Fri, 27 Feb
PTY
Panama City
MEX
Mexico City
S$903 Return, found 5 days ago
S$903
Return
found 5 days ago
Select American Airlines flight, departing Mon, 23 Feb from Panama City to Mexico City, returning Fri, 27 Feb, priced at S$903 found 5 days ago
American Airlines
Fri, 20 Feb - Tue, 24 Feb
PTY
Panama City
MEX
Mexico City
S$905 Return, found 5 days ago
S$905
Return
found 5 days ago
Select American Airlines flight, departing Fri, 20 Feb from Panama City to Mexico City, returning Tue, 24 Feb, priced at S$905 found 5 days ago
American Airlines
Fri, 20 Feb - Tue, 24 Feb
PTY
Panama City
MEX
Mexico City
S$918 Return, found 5 days ago
S$918
Return
found 5 days ago
Select American Airlines flight, departing Fri, 20 Feb from Panama City to Mexico City, returning Tue, 24 Feb, priced at S$918 found 5 days ago
United
Fri, 20 Feb - Tue, 24 Feb
PTY
Panama City
MEX
Mexico City
S$1,703 Return, found 5 days ago
S$1,703
Return
found 5 days ago
Select United flight, departing Fri, 20 Feb from Panama City to Mexico City, returning Tue, 24 Feb, priced at S$1,703 found 5 days ago

Find the cheapest month to fly from Panama City (PTY) to Mexico City (MEX)

November is typically the cheapest month to fly

From S$302 - S$585 per traveller.
Panama City to Mexico City route information
Origin airport
Tocumen Intl.
Destination airport
Mexico City Intl.
Return price
S$525
Distance
2397 km
Average flight time
2 hours 55 mins

Flights from Tocumen to Mexico City

There are several airlines that operate frequent flights from Panama (PTY) to Mexico City (MEX) including

  • COPA Airlines with 116 flights a week
  • Aeromexico with 63 flights a week
  • AVIANCA with 15 flights a week

The earliest flight leaves Tocumen Intl. Airport at 07:32 and arrives at Mexico City Intl. Airport at 00:17. The last flight of the day departs Panama at 21:23 and arrives at Mexico City at 23:08.

The flight distance from Panama to Mexico City is about 2423 km, the shortest flight is 03 hours 54 minutes with COPA Airlines.

Expedia lets you search across the largest number of airlines and Mexico City flights, which means that you’ll be able to find a great flight deal at the perfect travel date and time. Our simple-to-use booking engine makes looking for terrific bargains easy and hassle-free; just enter your travel dates and departure city, and let Expedia do the rest! Adjust your travel dates and explore connecting flights to find an even better deal on your Tocumen Mexico City flight!

Browse through dozens of options and rest assured that you’re seeing the best price guaranteed! Our friendly customer service representatives are here to serve you 24 hours day to provide assistance and answer any questions that you may have about booking your Tocumen to Mexico City trip. There’s simply no substitute for great prices suited to your travel needs and backed by excellent customer support.

Combine your Mexico City flight with a hotel and/or car rental for a package deal designed to save you even more money! Discover additional savings by booking in advance or find a last minute deal. There are tons of ways to save on your flights from Tocumen to Mexico City with Expedia. Use us as your stop travel destination and have the confidence that you’re getting a bargain!

Frequently asked questions

How much is a flight from Panama Airport to MEX?
Within the past 7 days on Expedia, for flights departing within the next year, the lowest price available for a round-trip journey between Panama Airport and Benito Juárez Intl. Airport was S$525. Great fares don't last forever, so make sure you book yours ASAP. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Panama Airport to MEX?
When it comes to cancellation fees, each airline has its own terms and conditions. If you decide to cancel your trip, head to our Customer Service Portal.
How do I find cheap flights from Tocumen Intl. Airport (PTY) to Mexico Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Panama Airport to Benito Juárez Intl. Airport flights, you'll see a "no change fees" filter for you to select.
How far is the flight from Tocumen Intl. Airport (PTY) to Mexico Airport?
Around 2,400 kilometres separates Tocumen and Mexico City, so pack some entertainment to keep you occupied for a few hours. That gripping novel you've yet to start will be perfect.
Which airlines fly direct from Panama Airport to Mexico City Intl. Airport (MEX)?
Operating 147 flights monthly, Copa Airlines (CM) is a top choice when flying straight from PTY to Mexico Airport.
Are Panama Airport to Mexico Airport flight tickets cheaper when they're purchased at the last minute?
Tickets from Tocumen Intl. Airport (PTY) to MEX are available up to a year prior to departure on Expedia. And although you may nab a fantastic last-minute deal, it's never a sure thing. Also, booking your flights well in advance means you'll have more options — and you can avoid getting caught in the dreaded middle seat! We regularly update our fares to bring you the biggest bargains, so check back often for all the latest specials.

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