A bench, a bicycle, and a lake surrounded by trees.

Four Star Hotels in Upstate South Carolina

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina 4 Star Hotels

Tonight
5 Sept - 6 Sept
Tomorrow
6 Sept - 7 Sept
Next weekend
11 Sept - 13 Sept
In two weeks
18 Sept - 20 Sept

Our top choices for Upstate South Carolina 4-star hotels

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.
A bar with multiple shelves of liquor bottles and glasses hanging above.

1. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
S$260
includes taxes & fees
4 Oct - 5 Oct
Hotel Hartness
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
S$502
includes taxes & fees
27 Sept - 28 Sept
Grand Bohemian Lodge Greenville, Autograph Collection
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A lobby with patterned flooring, a grand staircase, and elegant furniture.
A banquet hall with round tables, chandeliers, and ornate windows.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
S$261
includes taxes & fees
6 Sept - 7 Sept
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Channell
S$146
includes taxes & fees
8 Sept - 9 Sept
Mint House Greenville Downtown by Kasa
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.

5. Greenville Marriott

Greenville Marriott
Greenville
United States
richard
S$171
includes taxes & fees
14 Sept - 15 Sept
Greenville Marriott
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
S$323
includes taxes & fees
6 Sept - 7 Sept
The Shepherd Hotel Downtown Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
S$214
includes taxes & fees
7 Sept - 8 Sept
The Abernathy of Clemson
A modern building with outdoor seating and a garden.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.

8. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveller
S$388
includes taxes & fees
6 Sept - 7 Sept
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
S$514
includes taxes & fees
7 Sept - 8 Sept
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.

10. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A modern living room with a sofa, a coffee table, and a fireplace.

11. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.
A cozy living room with a fireplace, leather armchair, and a large window.

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A wooden deck with a table and chairs, surrounded by trees.
A wooden deck with a table and chairs, surrounded by trees.

13. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.

14. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A modern kitchen with a central island, stainless steel appliances, and pendant lighting.
A covered patio area with outdoor seating, large windows, and a white exterior.
A two-story house with a front porch, a garage, and a small front yard with landscaping.
A modern kitchen with white cabinets, a stainless steel refrigerator, and pendant lighting.

15. Steps to Lake Greenwood: Waterfront Gem w/ Patio

Steps to Lake Greenwood: Waterfront Gem w/ Patio
Greenwood
United States
Luetrina
Steps to Lake Greenwood: Waterfront Gem w/ Patio
A marina with boats docked, a wooden pier, and a clear sky.
A multi-story hotel with a parking lot and a view of a lake.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A swimming pool with a view of the lake and docked boats.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A marina with boats docked, surrounded by greenery and trees.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.
A multi-story hotel with a parking lot and a view of a lake.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A marina with boats docked, surrounded by greenery and trees.
A swimming pool with a view of a lake and docked boats.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A large indoor swimming pool with clear lanes, a covered roof, and seating areas along the sides.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
A sandy beach with a calm lake surrounded by trees.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Heritage Park and CCNB Amphitheatre.

See all hotels in Upstate South Carolina
A multi-tiered waterfall cascading over rocks in a forested area.
Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

8/10 Good
"Nice property that is extremely well located relative to downtown Greenville. Staff and facilities were first rate but I found the decor slightly tacky."
Henry R 1-night trip
Posted 8 days ago
Grand Bohemian Lodge Greenville, Autograph Collection

Find out more about Upstate South Carolina

Take Your Pick of 4 Star Hotels in Upstate South Carolina

The get-go of any holiday starts with choosing a great spot. Upstate South Carolina has been a popular destination with guests because it offers so much to do and see. But, "location, location, location" applies to more than just what city where your plane lands. Now that you have a feel for the town, it's time you to get to know your new digs.

Accommodations as Picturesque as Upstate South Carolina

Search Expedia.com.sg for the right 4 Star Upstate South Carolina Hotel to suit your fancy. Plenty of these people wrote tips to help you select the accommodation that is the right fit for your holiday.You'll be more than glad to get back to your resort every night. Upstate South Carolina has dozens of good options in the 4-star hotel range that create the ideal getaway.

A stay at one of these lodgings ensure that whether you are just relaxing after a day of checking out Upstate South Carolina or you are ready to lie down for the night, you'll be as comfortable as possible. You won't go without a thing during your stay at one of these accommodations. Visitors have consistently given them high marks for their attentive service. It's no surprise that loads of guests recommend it.

Reserve a 4-Star Hotel in Upstate South Carolina Today!

Your trip to Upstate South Carolina should be one that you'll reminisce over for years to come, and booking a 4-star hotel will help create memories that are incredible. Make sure to make a reservation soon. With so few hotels, and plenty of people desiring to vacation in Upstate South Carolina, you may miss out on your perfect hotel.

Explore a world of travel with Expedia