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Check prices for these dates

Next weekend
22 Aug - 24 Aug
In two weeks
29 Aug - 31 Aug
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12 Sept - 14 Sept
In two months
10 Oct - 12 Oct

Featured Apartments in Defiance

Zia New Haven
Living room

Zia New Haven

3.5 star property
9.8 out of 10, Exceptional, (8)
"The property was well kept up and the owners provided everything you could need for a comfortable stay. Laura is very sweet and made us feel very welcome for our 25th wedding anniversary. I highly recommend staying here. The town is small but it is only a short distance to wineries, distilleries and many other things of interest. "
Zia New Haven
'the Ruebling House': Bright, Modern, & Renovated!
Interior

'the Ruebling House': Bright, Modern, & Renovated!

3.0 star property
'the Ruebling House': Bright, Modern, & Renovated!
Augusta Studio at Halcyon Spa Bed & Breakfast
Property grounds

Augusta Studio at Halcyon Spa Bed & Breakfast

3.0 star property
10.0 out of 10, Exceptional, (1)
"Everything was great with this place"
Augusta Studio at Halcyon Spa Bed & Breakfast
Lovely Couples Escape on Mississippi River!
Interior

Lovely Couples Escape on Mississippi River!

3.0 star property
10.0 out of 10, Exceptional, (2)
"Amazing place to stay, quiet and relaxing would definitely stay there again"
Lovely Couples Escape on Mississippi River!
New Melle Apartment Near Missouri Wine Country
Interior

New Melle Apartment Near Missouri Wine Country

3.0 star property
10.0 out of 10, Exceptional, (1)
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
New Melle Apartment Near Missouri Wine Country
The Ruebling House Cozy Defiance Apartment!
Interior

The Ruebling House Cozy Defiance Apartment!

3.0 star property
The Ruebling House Cozy Defiance Apartment!
'the Ruebling House' Historic Defiance Apartment!
Interior

'the Ruebling House' Historic Defiance Apartment!

3.0 star property
10.0 out of 10, Exceptional, (1)
"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."
'the Ruebling House' Historic Defiance Apartment!
The Merlot Bungalow Defiance Tiny Home on Trail
Interior

The Merlot Bungalow Defiance Tiny Home on Trail

3.0 star property
The Merlot Bungalow Defiance Tiny Home on Trail
'the Chardonnay Chalet' Defiance Studio Trail!
Interior

'the Chardonnay Chalet' Defiance Studio Trail!

3.0 star property
'the Chardonnay Chalet' Defiance Studio Trail!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"Loved my stay here will be back "
Ashley 2-night trip
Posted 13 hours ago
Ameristar Casino Resort and Spa

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your holiday.
Why would you choose apartments instead of traditional hotels?
An apartment is often more spacious than a traditional hotel room and comes with a kitchen, so you can cook some of your meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want to stay away from the tourist areas.
What's the top apartment I should consider for a stay in Defiance?
Here's a top apartment in the area to consider: 'the Ruebling House': Bright, Modern, & Renovated!: Located 0.1 mi/0.2 km away in Defiance .
How many apartments will I find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather in Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you are planning a longer stay in Defiance. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can you save you a headache when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. Otherwise, look for flights into Lambert-St. Louis International Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, consider renting a car to explore more sights.