
Defiance Hotels from S$86
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Defiance
Family friendly
Pet friendly
Check prices for these dates
Our top choices for Defiance hotels

WoodSpring Suites St Peters-OFallon
WoodSpring Suites St Peters-OFallonSt. Peters
9.0 out of 10, Wonderful, (44 reviews)
The price is S$134
includes taxes & fees
23 Feb - 24 Feb

Quality Inn Foristell
Quality Inn ForistellForistell
8.2 out of 10, Very good, (941 reviews)
The price is S$108
includes taxes & fees
1 Mar - 2 Mar

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by WyndhamFenton
8.0 out of 10, Very good, (1,101 reviews)
The price is S$131
includes taxes & fees
23 Feb - 24 Feb

Holiday Inn Express & Suites St Peters by IHG
Holiday Inn Express & Suites St Peters by IHGSt. Peters
9.4 out of 10, Exceptional, (391 reviews)
The price is S$163
includes taxes & fees
1 Mar - 2 Mar

Baymont by Wyndham Warrenton
Baymont by Wyndham WarrentonWarrenton
7.4 out of 10, Good, (1,002 reviews)
The price is S$102
includes taxes & fees
1 Mar - 2 Mar

Hampton Inn St. Louis Wentzville
Hampton Inn St. Louis WentzvilleWentzville
9.0 out of 10, Wonderful, (662 reviews)
The price is S$196
includes taxes & fees
28 Feb - 1 Mar

Comfort Suites St Charles - St Louis
Comfort Suites St Charles - St LouisSt. Charles
8.4 out of 10, Very good, (1,006 reviews)
The price is S$123
includes taxes & fees
24 Feb - 25 Feb

Super 8 by Wyndham Warrenton
Super 8 by Wyndham WarrentonWarrenton
7.4 out of 10, Good, (629 reviews)
The price is S$86
includes taxes & fees
1 Mar - 2 Mar

Best Western Plus Fenton
Best Western Plus FentonFenton
9.2 out of 10, Wonderful, (208 reviews)
The price is S$133
includes taxes & fees
23 Feb - 24 Feb

Best Western Plus Washington Hotel
Best Western Plus Washington HotelWashington
9.2 out of 10, Wonderful, (662 reviews)
The price is S$186
includes taxes & fees
25 Feb - 26 Feb

Comfort Inn & Suites St. Louis - O'Fallon
Comfort Inn & Suites St. Louis - O'FallonO'Fallon
7.6 out of 10, Good, (1,004 reviews)
The price is S$121
includes taxes & fees
9 Mar - 10 Mar

Drury Inn & Suites St. Louis St. Peters
Drury Inn & Suites St. Louis St. PetersSt. Peters
9.4 out of 10, Exceptional, (1,011 reviews)
The price is S$160
includes taxes & fees
26 Feb - 27 Feb

Fairfield Inn & Suites Wentzville
Fairfield Inn & Suites WentzvilleWentzville
9.0 out of 10, Wonderful, (655 reviews)
The price is S$185
includes taxes & fees
1 Mar - 2 Mar

Holiday Inn Express Warrenton by IHG
Holiday Inn Express Warrenton by IHGWarrenton
9.0 out of 10, Wonderful, (522 reviews)
The price is S$157
includes taxes & fees
1 Mar - 2 Mar

Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66Fenton
8.0 out of 10, Very good, (1,147 reviews)
The price is S$116
includes taxes & fees
23 Feb - 24 Feb

Hampton Inn St. Charles St. Peters
Hampton Inn St. Charles St. PetersSt. Charles
8.0 out of 10, Very good, (1,002 reviews)
The price is S$154
includes taxes & fees
1 Mar - 2 Mar

Courtyard by Marriott St. Louis West County
Courtyard by Marriott St. Louis West CountyTown and Country
9.0 out of 10, Wonderful, (461 reviews)
The price is S$217
includes taxes & fees
27 Feb - 28 Feb

Super 8 by Wyndham Washington
Super 8 by Wyndham WashingtonWashington
8.4 out of 10, Very good, (707 reviews)
The price is S$119
includes taxes & fees
24 Mar - 25 Mar

Economy Inn Wentzville
Economy Inn WentzvilleWentzville
6.4 out of 10, (519 reviews)
The price is S$86
includes taxes & fees
23 Feb - 24 Feb

Quality Inn Near Six Flags St. Louis
Quality Inn Near Six Flags St. LouisPacific
8.4 out of 10, Very good, (366 reviews)
The price is S$136
includes taxes & fees
23 Feb - 24 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Defiance attractions
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

Comfort Suites St Charles - St Louis
10/10 Excellent
More cheap stays in Defiance

Relax Inn Saint Charles
3800 Harry S Truman Blvd St. Charles MO
The price is S$89 per night from 25 Feb to 26 Feb
S$89
25 Feb - 26 Feb
includes taxes & fees
6.8/10 (1,006 reviews)
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near Ameristar Casino St. Charles
- Hotels with free wifi in Brentwood
- Villas in Brentwood
- Romantic Hotels in Bridgeton
- Gay friendly Hotels in Chesterfield
- Chesterfield Hotels
- Crestwood Hotels
- Hotels with free wifi in Creve Coeur
- Hyatt Hotels in Creve Coeur
- Des Peres Hotels
- Earth City Hotels
- Ellisville Hotels
- Extended Stay America Hotels in Fenton
- Fenton Hotels
- Frontenac Hotels
- Grover Hotels
- Hotels near Hollywood Casino Amphitheatre
- Cabin Rentals in Kirkwood
- Cottages in Kirkwood
- Lake St Louis Hotels
- Hotels near Lambert-St. Louis Intl.
- Hotels near Lindenwood University
- Hotels with kitchenette in Maryland Heights
- Maryland Heights Hotels
- O'fallon Hotels
- Overland Hotels
- Pacific Hotels
- Rock Hill Hotels
- St. Ann Hotels
- B&B in St. Charles
- Marriott Hotels & Resorts in St. Charles
- St. Charles Hotels
- Villas in St. Charles
- St. Peters Hotels
- Villas in St. Peters
- Sunset Hills Hotels
- Town and Country Hotels
- Union Hotels
- Condo Rentals in Valley Park
- Valley Park Hotels
- Villa Ridge Hotels
- Weldon Spring Heights Hotels
- Wentzville Hotels
- Wildwood Hotels
- Wright City Hotels
- Flights to Green Park
- Flights to Lambert-St. Louis Intl.
- Flights to Maryland Heights
- Flights to St. Charles
- Flights to St. Peters
- Flights to Sunset Hills
- Flights to Warrenton
- Flights from Spirit of St. Louis
- Flights from Branson (BKG) to St. Louis (STL)
- Flights from Mumbai (BOM) to St. Louis (STL)
- Flights from Colorado Springs (COS) to St. Louis (STL)
- Flights from Denver (DEN) to St. Louis (STL)
- Flights from Dallas (DFW) to St. Louis (STL)
- Flights from Echuca (ECH) to St. Louis (STL)
- Flights from Elizabethtown (EKX) to St. Louis (STL)
- Flights from Ankara (ESB) to St. Louis (STL)
- Flights from Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
- Flights from Fergus Falls (FFM) to St. Louis (STL)
- Flights from Frankfurt (FRA) to St. Louis (STL)
- Flights from Seoul (ICN) to St. Louis (STL)
- Flights from Indianapolis (IND) to St. Louis (STL)
- Flights from Ilulissat (JAV) to St. Louis (STL)
- Flights from New York (JFK) to St. Louis (STL)
- Flights from Kahramanmaras (KCM) to St. Louis (STL)
- Flights from Chennai (MAA) to St. Louis (STL)
- Flights from Manila (MNL) to St. Louis (STL)
- Flights from Chicago (ORD) to St. Louis (STL)
- Flights from Seattle (SEA) to St. Louis (STL)
- Flights from San Francisco (SFO) to St. Louis (STL)
- Flights from Singapore (SIN) to St. Louis (STL)
- Flights from San Jose (SJC) to St. Louis (STL)
- Flights from Sarasota (SRQ) to St. Louis (STL)
- Flights from Vancouver (YVR) to St. Louis (STL)
- Bridgeton Holidays
- Dr. Edmund A. Babler Memorial State Park
- Hidden Valley Ski Resort
- Magic House - St. Louis Children's Museum
- National Equestrian Center
- Visit Olivette
- Overland Holidays
- Pacific Holidays
- Robertsville State Park
- Route 66 State Park
- Visit St. Charles
- Swing-A-Round Fun Town
- Wildwood Holidays












































































