𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Defiance (2026)

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Pool

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Hot tub

Family friendly

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Our top choices for Defiance hotels

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Breakfast included

Pet friendly

Bed & breakfast

Reserve now, pay later

A multi-story hotel with a brick facade, multiple windows, and a well-lit entrance.

A buffet with labeled containers of omelets and other dishes.

A modern kitchen with dark cabinetry, a built-in microwave, a coffee maker, and a bench.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

David

S$151

includes taxes & fees

27 Aug - 28 Aug

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A modern bathroom with a large mirror, white vanity, and a bathtub.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

2. The Wildwood Hotel

Wildwood

Hailey

S$117

includes taxes & fees

1 Sept - 2 Sept

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

A hotel lobby with a reception desk, seating area, and a large potted plant.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Josh

S$118

includes taxes & fees

13 Sept - 14 Sept

A hotel room with two beds, a desk, a chair, a TV, and a large window.

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A brick building with a sign reading "Comfort Inn & Suites."

A hotel with a central courtyard, a fountain, and a parking lot with several cars.

4. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Joe

S$129

includes taxes & fees

30 Aug - 31 Aug

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

5. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Cindy

S$191

includes taxes & fees

31 Aug - 1 Sept

A hotel entrance with a covered patio, stone pillars, and a bench.

A buffet area with a variety of fruits and packaged foods, a television mounted on the wall, and a window with blinds.

A multi-story hotel with a central entrance featuring a covered patio area.

A pool area with lounge chairs and a bench, surrounded by a building with multiple windows and a stone facade.

6. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

S$177

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

7. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

S$209

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

8. Residence Inn by Marriott O'Fallon

O'Fallon

Gerald

S$196

includes taxes & fees

13 Sept - 14 Sept

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

A modern dining area with a long table, multiple chairs, and pendant lighting.

9. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Karen E

S$162

includes taxes & fees

30 Aug - 31 Aug

An indoor swimming pool with lounge chairs, a children's play area, and a restaurant.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

A grand lobby with a stone fireplace, a wooden staircase, and a seating area with sofas and a coffee table.

A restaurant with outdoor seating, a bar area, and a view of the pool.

10. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

S$140

includes taxes & fees

21 Sept - 22 Sept

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A building entrance with glass doors, stone accents, and potted plants.

A modern hotel lobby with a sofa, chairs, a small table, and a bar area.

An outdoor patio with tables and chairs, a brick building, and a white fence.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

NEBAHAT

S$168

includes taxes & fees

30 Aug - 31 Aug

An outdoor patio area with wicker furniture and a central fire feature.

A hotel room with a bed, a sofa, a desk, and a chair.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

12. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

S$185

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.

A hotel room with a bathroom, a bed, a nightstand, and a window.

13. Quality Inn Near Six Flags St. Louis

Pacific

Diane

S$137

includes taxes & fees

20 Sept - 21 Sept

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

An outdoor patio with a beige sofa set, two armchairs, and a table.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

14. Best Western Plus Washington Hotel

Washington

Michael Macumber

S$186

includes taxes & fees

30 Aug - 31 Aug

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

15. Comfort Inn Near Six Flags St. Louis

Pacific

David

S$136

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a bed, two bedside lamps, a chair, a desk with a telephone, and a large cityscape poster on the wall.

A two-story building with a red roof and white siding, featuring a covered entrance and a small parking area.

A reception area with a counter, a utility room door, and a bulletin board with posted notices.

A diner-style restaurant with a counter, chairs, a coffee machine, and a wall poster.

16. Super 8 by Wyndham O'Fallon MO/St. Louis Area

O'Fallon

Shelly

S$99

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

17. Drury Inn & Suites St. Louis St. Peters

St. Peters

Melanie

S$161

includes taxes & fees

30 Aug - 31 Aug

A multi-story hotel with a stone facade and a covered entrance.

A compact hotel room with two beds, a desk with a chair, a television, a microwave, and a refrigerator.

A modern living room with a blue accent wall, a gray sofa, a dining table with chairs, and a coffee table.

A compact living space with a kitchenette, a dining area, and a workspace.

18. WoodSpring Suites St Peters-OFallon

St. Peters

Ellen

S$130

includes taxes & fees

25 Aug - 26 Aug

A spacious lobby with a central round table, two sofas, and a chandelier.

A buffet setup with various food items and a decorative vase of flowers.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

19. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Andrea T

S$191

includes taxes & fees

30 Aug - 31 Aug

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

A Hampton Inn with a brick facade, outdoor seating area, and a clear sky.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

A modern hotel room with a neatly made bed, a bedside table with a lamp, a wall-mounted artwork, and a small seating area with a bench.

20. Hampton Inn St. Louis Wentzville

Wentzville

Daniel

S$213

includes taxes & fees

30 Aug - 31 Aug

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Stay near popular Defiance attractions

A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO

S$100

26 Aug - 27 Aug

includes taxes & fees

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

S$118

13 Sept - 14 Sept

includes taxes & fees

9/10 Wonderful! (1,101 reviews)

Best Western Plus St. Louis West-Westport

12220 Dorsett Rd Maryland Heights MO

S$136

6 Sept - 7 Sept

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

S$142

30 Aug - 31 Aug

includes taxes & fees

8/10 Very good! (1,004 reviews)

Best Western Plus Fenton

1680 Fenton Business Park Ct Fenton MO

S$145

31 Aug - 1 Sept

includes taxes & fees

9/10 Wonderful! (439 reviews)

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

11 Arnage Boulevard Chesterfield MO

S$168

30 Aug - 31 Aug

includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. Ameristar Casino Resort and Spa and The Wildwood Hotel are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Defiance Hotels from S$99

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

2. The Wildwood Hotel

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

4. Comfort Inn & Suites Chesterfield - St. Louis

5. TownePlace Suites by Marriott St. Louis Chesterfield

6. Staybridge Suites O'Fallon Chesterfield by IHG

7. Hilton Garden Inn St. Louis/O'Fallon MO

8. Residence Inn by Marriott O'Fallon

9. Hampton Inn & Suites St. Louis/Chesterfield

10. Holiday Inn St. Louis West Six Flags by IHG

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

12. Courtyard by Marriott St. Louis Chesterfield

13. Quality Inn Near Six Flags St. Louis

14. Best Western Plus Washington Hotel

15. Comfort Inn Near Six Flags St. Louis

16. Super 8 by Wyndham O'Fallon MO/St. Louis Area

17. Drury Inn & Suites St. Louis St. Peters

18. WoodSpring Suites St Peters-OFallon

19. Drury Plaza Hotel St. Louis Chesterfield

20. Hampton Inn St. Louis Wentzville

Stay near popular Defiance attractions

August A. Busch Memorial Conservation Area

Chandler Hill Vineyards

Historic Daniel Boone Home and Heritage Center

Sugar Creek Winery

Yellow Farmhouse Winery

Matson Hill Park Trailhead

Broemmelsiek Park

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Sleep Inn & Suites O'Fallon MO - Technology Drive

Best Western Plus St. Louis West-Westport

Hampton Inn St. Charles St. Peters

Best Western Plus Fenton

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Frequently asked questions

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