Default HTG hotel image

Hotels near Florida Keys National Marine Sanctuary

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
10 Jul - 12 Jul
Next weekend
17 Jul - 19 Jul

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Florida Keys National Marine Sanctuary hotels

Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,011 reviews)
"The hotel staff was absolutely amazing. They were so knowledgeable about what was available in Key West, and they were so kind. We loved our time at The Almond Tree and most definitely will stay there every trip to Key West moving forward."
United States
Patricia
The price is S$288
includes taxes & fees
13 Jul - 14 Jul
Almond Tree Inn Hotel - Adults Only
Property grounds

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,003 reviews)
"Great boutique hotel in the perfect location !! "
United States
Michael
The price is S$279
includes taxes & fees
12 Jul - 13 Jul
Orchid Key Inn - Adults Only
Exterior detail

The Gardens Hotel

The Gardens Hotel
4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,005 reviews)
"Whole place is great"
United States
Joseph
The price is S$289
includes taxes & fees
12 Jul - 13 Jul
The Gardens Hotel
Front of property

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (267 reviews)
"This was the best place we have stayed at in Key West! It was super quiet but only a block from Duval. The owners really put a lot of care into the place and are super nice! Definitely would stay there again! "
United States
Jennifer
The price is S$260
includes taxes & fees
9 Jul - 10 Jul
Key West Villas
Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,006 reviews)
"Perfcet location and walk to everything , we very much enjoyed our stay!"
United States
Rita
The price is S$211
includes taxes & fees
8 Jul - 9 Jul
Simonton Court Historic Inn & Cottages
Restaurant

Artist House Key West

Artist House Key West
3.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (446 reviews)
"Great atmosphere and location."
United States
NATHAN
The price is S$212
includes taxes & fees
19 Jul - 20 Jul
Artist House Key West
Exterior

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (441 reviews)
"Great stay"
United States
Matthew
The price is S$212
includes taxes & fees
14 Jul - 15 Jul
Douglas House - Adults Only
Exterior

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,000 reviews)
"Friendly and helpful staff, and the rooms were exceptionally clean and comfortable. Everything was well-maintained, and the overall experience was wonderful. I will definitely be coming back again!"
United States
Helia
The price is S$401
includes taxes & fees
2 Aug - 3 Aug
The Marquesa Hotel
Premium bedding, pillow-top beds, individually decorated

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (417 reviews)
"Very friendly staff and a prime location."
United States
Akhenaton
The price is S$327
includes taxes & fees
6 Aug - 7 Aug
Tropical Inn
Terrace/patio

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (179 reviews)
"Great location "
United Kingdom
Lucy
The price is S$310
includes taxes & fees
4 Aug - 5 Aug
The Conch House Heritage Inn
Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Weatherstation Inn
2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,005 reviews)
"Quaint place to stay with access to there other more resort style property made for an amazing experience."
United States
Bret
The price is S$260
includes taxes & fees
8 Jul - 9 Jul
Weatherstation Inn
View from room

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (623 reviews)
"We had a wonderful stay!"
United States
Elizabeth
The price is S$565
includes taxes & fees
8 Jul - 9 Jul
H2O Suites - Adults Only
Exterior

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (541 reviews)
"Loved the property and staff was super friendly."
United States
Brinkley
The price is S$243
includes taxes & fees
13 Jul - 14 Jul
Coco Plum Inn
Property grounds

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,043 reviews)
"Great location and clean rooms. Breakfast staff is so sweet! Will stay here again for sure!!"
United States
Wendy S
The price is S$215
includes taxes & fees
21 Jul - 22 Jul
Duval House
Terrace/patio

The Mermaid & Alligator

The Mermaid & Alligator
3.5 star property
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (305 reviews)
"Great location, lovely place, clean and comfortable room. Highly recommend! "
United States
Mary
The price is S$311
includes taxes & fees
9 Jul - 10 Jul
The Mermaid & Alligator
Front of property

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,005 reviews)
"Loved the location, breakfast and clean room. Staff, Drew, very friendly and helpful. Will definitely stay here again."
United States
Richard
The price is S$170
includes taxes & fees
13 Jul - 14 Jul
L'Habitation Guest House
Terrace/patio

Marrero's Guest Mansion

Marrero's Guest Mansion
3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (337 reviews)
"Service and hospitality were exceptional. Will stay again. "
United States
Don
The price is S$311
includes taxes & fees
4 Aug - 5 Aug
Marrero's Guest Mansion
Balcony view

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,002 reviews)
"I love this Hotel. Great location, safe m, convenient. The staff is very accommodating."
United States
Paul
The price is S$249
includes taxes & fees
14 Jul - 15 Jul
Island City House Hotel
3 outdoor pools, a heated pool, pool loungers

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,002 reviews)
"Great location and breakfast"
United States
Lori
The price is S$235
includes taxes & fees
8 Jul - 9 Jul
Ambrosia Key West
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers

Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (487 reviews)
"Beautiful, boutique little gem with a wonderful staff!"
United States
Karri
The price is S$322
includes taxes & fees
14 Jul - 15 Jul
Ella's Cottages - Key West Historic Inns
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Almond Tree Inn Hotel - Adults Only
3.5 star property
10.0
Exceptional
1,011 reviews
View
Property grounds
Orchid Key Inn - Adults Only
3.5 star property
9.8
Exceptional
1,003 reviews
View
Exterior detail
The Gardens Hotel
4.0 star property
9.8
Exceptional
1,005 reviews
View
Front of property
Key West Villas
3.5 star property
9.8
Exceptional
267 reviews
View
Minibar, in-room safe, individually decorated, individually furnished
Simonton Court Historic Inn & Cottages
2.5 star property
9.8
Exceptional
1,006 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

10/10 Excellent
"The hotel was clean—staff were super pleasant. Location was superb!! Worth every penny!!!! Cookies—slippers—-unlimited water—sunblock at the pool—cool towels—ice pops—honestly the hotel was perfect. I would recommend it over and over—and we landed here out of luck. The other side of the island has a bad case of sargassum so we needed to switch hotels—best switch ever!!!!"
Lori 3-night trip
Posted 10 hours ago
Opal Key Resort & Marina, Key West

Hotels near other Florida Keys National Marine Sanctuary attractions

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1534 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveller data, and this B&B offers free breakfast and private balconies. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1534 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Coffee Butler Amphitheater, Key West Film Society and Red Barn Theater if you're interested in local theatre.