⭐ Top 10 Hotels Near Florida Keys National Marine Sanctuary for 2026

Our top choices for Florida Keys National Marine Sanctuary hotels

Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds

Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Renee

includes taxes & fees

27 May - 28 May

The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Markus

includes taxes & fees

21 Jun - 22 Jun

Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Vicki

includes taxes & fees

25 May - 26 May

Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jennifer

includes taxes & fees

26 May - 27 May

Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

kelly

includes taxes & fees

7 Jun - 8 Jun

Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Scott

includes taxes & fees

2 Jun - 3 Jun

The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Julian

includes taxes & fees

16 Jun - 17 Jun

Premium bedding, pillow-top beds, individually decorated

Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Akhenaton

includes taxes & fees

26 May - 27 May

The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Lucy

includes taxes & fees

1 Jun - 2 Jun

Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

A. Elise

includes taxes & fees

25 May - 26 May

H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Barton

includes taxes & fees

2 Jun - 3 Jun

Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Brinkley

includes taxes & fees

2 Jun - 3 Jun

Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Michael

includes taxes & fees

2 Jun - 3 Jun

Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Parmjit

includes taxes & fees

25 May - 26 May

Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Robert

includes taxes & fees

4 Jun - 5 Jun

Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Cindy

includes taxes & fees

27 May - 28 May

Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers

Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

DJS Darren Jay

includes taxes & fees

3 Jun - 4 Jun

3 outdoor pools, a heated pool, pool loungers

Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tina

includes taxes & fees

25 May - 26 May

The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Jacqueline

includes taxes & fees

27 May - 28 May

Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Keith

includes taxes & fees

25 May - 26 May

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,018 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,000 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,007 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 261 reviews	View
Simonton Court Historic Inn & Cottages	2.5 star property	9.8 Exceptional 960 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

10/10 Excellent

"Location is great, on site parking is easy, view is excellent, staff is friendly."

Wicker Guesthouse

6/10 Okay

"Very small room, no space for a chair. The floor was sinking in 2 places so the laminate flooring was coming apart. The parking situation is unacceptable, especially when you drive a $90,000 sports car. They want to keep your keys in case they need to move your car. The window a/c worked fine. The decor was pleasant. The continental breakfast was ok. The staff was ok, except with a bit of attitude. Would I ever return? I don’t think so. Sorry guys, but you asked"

Southernmost Beach Resort and Guesthouses

8/10 Good

"Upon check in - I was informed I needed a CC with $1200.00 available on it - at no point was I instructed of this need - I had paid for my stay prior as I do not use CC - thank goodness some in my party had one to use. The front desk person was not friendly about this = I have read my information from Expedia and nowhere is it stated - nor is it on your resort site. The bar at the pineapple pool was on point - Annette at the front desk was very helpful also. Breakfast at the cafe was well priced and good. My room was also always cleaned - Like i previously said the only complaint would be about the credit card and how the front desk person was not kind or friendly regarding this."

Casa Marina Key West, Curio Collection by Hilton

8/10 Good

"It was centrally located. I wish the beach was more maintained for being advertised as the largest private beach in all of key west. The staff was helpful, but wasn’t extraordinary. The pools were very nice. The outdoor bar was okay. The gift shop was very nice. The rooms were mostly clean. There was a lot of dust and dirt as well as sand in corners of the room, especially in the bathroom. Room service only came when we called to request which was odd. The Florida Resort tax should’ve been made more clear, as well as the mandatory $800 card hold they charge the tax out of per night."

Southwinds Motel

8/10 Good

"The rooms were very clean and had everything we needed. Coffee pot/microwave/refrigerator was a plus - every hotel we look for has to have those three things. The staff was friendly and was able to check us in early. The only issue was the noise factor - our rooms were close to the front of the property so the music from the bar and traffic from the street was a bit frustrating because we are used to quiet, but other than that the stay was great."

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1554 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Florida Keys National Marine Sanctuary?

Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Opal Key Resort & Marina, Key West.

How many hotels will I find near Florida Keys National Marine Sanctuary?

Expedia has 1554 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society and Red Barn Theater if you're interested in local theatre.

Hotels near Florida Keys National Marine Sanctuary

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Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

The Gardens Hotel

Orchid Key Inn - Adults Only

Key West Villas

Simonton Court Historic Inn & Cottages

Douglas House - Adults Only

The Marquesa Hotel

Tropical Inn

The Conch House Heritage Inn

Weatherstation Inn

H2O Suites - Adults Only

Coco Plum Inn

Island City House Hotel

Duval House

Marrero's Guest Mansion

Santa Maria Suites

Ella's Cottages - Key West Historic Inns

Ambrosia Key West

The Grand Guesthouse

Silver Palms Inn & Historic Homes

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

Frequently asked questions