𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 O Brien (2026)

A calm river with clear water, surrounded by dense trees and rocky banks.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in O Brien

Pet friendly

Apartment

Pool

Family friendly

Waterpark

Condo

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for O Brien hotels

A covered outdoor area with a paved walkway, benches, and potted plants.

A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

A bedroom with a bed, a desk, a chair, and a ceiling fan.

A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

1. Cindys Motel

Mayo

Diane

S$120

includes taxes & fees

22 Sept - 23 Sept

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

2. Fairfield Inn & Suites Lake City

Lake City

Thomas

S$140

includes taxes & fees

29 Aug - 30 Aug

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

3. Super 8 by Wyndham Lake City

Lake City

Mari

S$93

includes taxes & fees

23 Aug - 24 Aug

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern hotel lobby with a fireplace, seating areas, and a bar.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.

4. Comfort Suites Lake City

Lake City

KHAJA

S$133

includes taxes & fees

31 Aug - 1 Sept

A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.

A Hampton Inn & Suites hotel with a modern design, featuring a prominent red sign, a covered entrance, and a parking area.

An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.

A hotel with a blue and white facade, a covered entrance, and a parking lot.

5. Hampton Inn & Suites Lake City

Lake City

tracy

S$156

includes taxes & fees

23 Aug - 24 Aug

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

6. Best Western Plus Lake City

Lake City

Stephan

S$117

includes taxes & fees

30 Aug - 31 Aug

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.

An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

7. Tru by Hilton Lake City

Lake City

James

S$156

includes taxes & fees

24 Aug - 25 Aug

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A wooden cabin with a porch, a front door, and a small window.

A serene lakeside campsite with picnic tables and chairs.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

8. Suwannee River Rendezvous

Mayo

Beth

S$153

includes taxes & fees

22 Sept - 23 Sept

A buffet with labeled containers of omelets and other dishes.

A hotel room with two beds, a desk, a chair, and a window with a view.

A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.

A reception area with a counter, seating, and a fireplace.

9. Holiday Inn Express & Suites Live Oak by IHG

Live Oak

Trisha

S$148

includes taxes & fees

20 Sept - 21 Sept

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

10. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Priscilla J

S$134

includes taxes & fees

21 Sept - 22 Sept

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

11. Americas Best Value Inn Lake City

Lake City

Larissa

S$93

includes taxes & fees

25 Aug - 26 Aug

An outdoor patio area with wicker chairs, a round table, and a fire pit.

A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.

A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.

12. TownePlace Suites by Marriott Lake City

Lake City

Jennifer

S$170

includes taxes & fees

23 Aug - 24 Aug

A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.

Two doors, one blue and one green, with numbers 105 and 103 respectively, against a brick wall.

A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.

A bathroom with a bathtub, a shower, and a toilet.

13. Regal Inn

Lake City

Samuel

S$82

includes taxes & fees

23 Aug - 24 Aug

A spacious lobby with multiple seating areas, a bar, and a large window with a view.

A hotel lobby with multiple dining areas, round tables, and cushioned chairs.

A modern hotel lobby with a sectional sofa, a reception desk, and a computer workstation.

A Holiday Inn hotel with a covered entrance, multiple floors, and palm trees.

14. Holiday Inn & Suites Lake City by IHG

Lake City

Renee

S$139

includes taxes & fees

30 Aug - 31 Aug

A hotel room with two beds, a TV, a desk, and a painting of a sunset.

A reception area with a wooden counter, a clock, and a computer on a desk.

A kitchen with a black refrigerator and a microwave on a wooden shelf.

A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

15. Days Inn by Wyndham Lake City I-75

Lake City

Brizheet

S$90

includes taxes & fees

23 Aug - 24 Aug

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

A hotel with a swimming pool, white lounge chairs, and a fenced area.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

16. Quality Inn White Springs Suwanee

White Springs

Rowan

S$91

includes taxes & fees

23 Aug - 24 Aug

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.

17. Courtyard By Marriott Lake City

Lake City

Tonya

S$153

includes taxes & fees

30 Aug - 31 Aug

A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.

A bathroom with a large mirror, a sink, and a towel rack.

A corner room with two checkered chairs, a small table, a framed picture on the wall, and a floor lamp.

A reception area with a counter, a computer, and a bulletin board with pamphlets.

18. Palms Garden Inn

Lake City

Teresa

S$98

includes taxes & fees

31 Aug - 1 Sept

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A reception area with a counter, a coffee machine, and a potted plant.

A white building with multiple windows and a sign that reads 'Quality Inn.'

A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

19. Quality Inn Lake City

Lake City

Lucille

S$104

includes taxes & fees

21 Sept - 22 Sept

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

A modern hotel lobby with a reception desk, seating areas, and a large screen.

A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

20. Home2 Suites by Hilton Lake City

Lake City

William

S$175

includes taxes & fees

6 Sept - 7 Sept

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Best Western Plus Lake City

10/10 Excellent

"We were there for two nights and everything was excellent"

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Clean room good staff"

Tru by Hilton Lake City

8/10 Good

"Not a bad place to stay. Pillows could have been better, but I'm pretty picky. I'd stay again if in the area."

La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent

"Parking. Breakfast, staff was good"

Baymont by Wyndham Lake City I-75

10/10 Excellent

"Nice place"

Super 8 by Wyndham Lake City

10/10 Excellent

"Everything was wonderful"

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

3430 N Us Highway 441 Lake City FL

S$85

23 Aug - 24 Aug

includes taxes & fees

7/10 Good! (1,019 reviews)

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

S$104

21 Sept - 22 Sept

includes taxes & fees

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

S$117

30 Aug - 31 Aug

includes taxes & fees

9/10 Wonderful! (1,103 reviews)

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

S$133

31 Aug - 1 Sept

includes taxes & fees

Hampton Inn & Suites Alachua I-75

15930 Northwest 163rd Lane Alachua FL

S$151

1 Sept - 2 Sept

includes taxes & fees

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

S$156

24 Aug - 25 Aug

includes taxes & fees

9.2/10 Wonderful! (1,004 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?

Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What are some accommodation options with pools in O Brien?

Best Western Plus Lake City: Provides a snack bar/deli, an indoor pool and buffet. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

O Brien Hotels from S$71

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for O Brien hotels

1. Cindys Motel

2. Fairfield Inn & Suites Lake City

3. Super 8 by Wyndham Lake City

4. Comfort Suites Lake City

5. Hampton Inn & Suites Lake City

6. Best Western Plus Lake City

7. Tru by Hilton Lake City

8. Suwannee River Rendezvous

9. Holiday Inn Express & Suites Live Oak by IHG

10. La Quinta Inn & Suite by Wyndham Lake City

11. Americas Best Value Inn Lake City

12. TownePlace Suites by Marriott Lake City

13. Regal Inn

14. Holiday Inn & Suites Lake City by IHG

15. Days Inn by Wyndham Lake City I-75

16. Quality Inn White Springs Suwanee

17. Courtyard By Marriott Lake City

18. Palms Garden Inn

19. Quality Inn Lake City

20. Home2 Suites by Hilton Lake City

Learn more about O Brien

Top O Brien Hotel Reviews

Best Western Plus Lake City

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Tru by Hilton Lake City

La Quinta Inn & Suite by Wyndham Lake City

Baymont by Wyndham Lake City I-75

Super 8 by Wyndham Lake City

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Hampton Inn & Suites Alachua I-75

Tru by Hilton Lake City

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app