Hotels in Sanctuary

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Tonight
12 Dec - 13 Dec
Tomorrow
13 Dec - 14 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Sanctuary hotels

Aerial view
DiamondHead Beach Resort

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.0 out of 10, Wonderful, (1001)
"Everything about this resort is spectacular! Staff, amenities, room! We had a wonderful stay!"
United States
Minda
DiamondHead Beach Resort
Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1002)
"Excellent stay over Thanksgiving holiday!"
United States
Nicole
The price is S$260
includes taxes & fees
21 Dec - 22 Dec
The Westin Cape Coral Resort At Marina Village
View from property
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very good, (1003)
"This was thr best place that we have ever stayed at. "
United States
Matthew
The price is S$319
includes taxes & fees
15 Dec - 16 Dec
Marriott Sanibel Harbour Resort & Spa
Sun deck
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1003)
"Great Place to Stay!"
United States
JUDY
The price is S$138
includes taxes & fees
14 Dec - 15 Dec
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Exterior
Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1191)
"Friendly staff, fun kid events "
United States
Payge
The price is S$375
includes taxes & fees
11 Jan - 12 Jan, 2026
Pink Shell Beach Resort and Marina
Marina
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina
3.0 star property
21.6 km from Sanctuary
9.2 out of 10, Wonderful, (1002)
"Was great location "
United States
Jose
The price is S$171
includes taxes & fees
14 Dec - 15 Dec
Matanzas Inn Bayside Resort and Marina
Exterior
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1000)
"Great rooms, good staff"
United States
Dedan
The price is S$140
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2 outdoor pools
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
21.5 km from Sanctuary
8.6 out of 10, Excellent, (1567)
"Great location… the tiki bar was the best bar on the beach.. not just on weekends, allllllll week "
United States
Adam
The Lighthouse Resort Inn & Suites
3 restaurants, breakfast, lunch, dinner served; Italian cuisine
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1007)
"Clean rooms, friendly staff, so much to do there and nearby "
United States
Lisa R
The price is S$232
includes taxes & fees
17 Dec - 18 Dec
Lani Kai Beachfront Resort
Outdoor pool, pool cabanas (surcharge), pool loungers
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (1697)
"Great place "
United States
Debra Sue
The price is S$318
includes taxes & fees
17 Dec - 18 Dec
Margaritaville Beach Resort Fort Myers
Beach/ocean view
Edison Beach House

Edison Beach House

Edison Beach House
3.5 star property
21.2 km from Sanctuary
9.4 out of 10, Exceptional, (1578)
"Awesome stay "
United States
mary
The price is S$308
includes taxes & fees
15 Dec - 16 Dec
Edison Beach House
Free daily buffet breakfast
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1000)
"Clean room, wonderful staff, and nice breakfast. "
United States
Danielle
The price is S$137
includes taxes & fees
18 Dec - 19 Dec
Residence Inn by Marriott Fort Myers Sanibel
Terrace/patio
Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (905)
"Wonderful stay at the property. It was hard to leave."
United States
Aaron
Latitude 26 Waterfront Resort & Marina
Bar (on property)
Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1004)
"Liked the evening cookies, rooms were clean, would have liked bathtub and hotter water the first am but overall great location "
United States
NINA
The price is S$188
includes taxes & fees
18 Dec - 19 Dec
Doubletree by Hilton Fort Myers at Bell Tower Shops
Living area
TriLuxe Inn & Studios

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very good, (16)
"Everything was great, will definitely be coming back"
United States
Ruben
The price is S$125
includes taxes & fees
14 Dec - 15 Dec
TriLuxe Inn & Studios
Balcony view
Lovers Key Resort

Lovers Key Resort

Lovers Key Resort
3.0 star property
30.3 km from Sanctuary
8.8 out of 10, Excellent, (1016)
"Nice place"
United States
patrick
Lovers Key Resort
In-room safe, desk, laptop workspace, blackout curtains
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1032)
"Hotel was very clean and the breakfast had a great variety."
United States
Lynn
The price is S$163
includes taxes & fees
15 Dec - 16 Dec
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Property amenity
Island Inn

Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1121)
"Really nice, updated, and clean room with a screened waterfront balcony in a perfect place on the island (far enough away from the big resorts to be in a quieter area, but close enough to the center area of the island to be convenient). "
United States
Chris
The price is S$301
includes taxes & fees
14 Dec - 15 Dec
Island Inn
Lobby
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.4 out of 10, Very good, (1003)
"Everything about this stay was wonderful. "
United States
John
The price is S$149
includes taxes & fees
18 Dec - 19 Dec
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Terrace/patio
Dolphin Key Resort

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1205)
"Very nice staff, great shower set up, the on site restaurant was very good. "
United States
Chuck
The price is S$144
includes taxes & fees
15 Dec - 16 Dec
Dolphin Key Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.
Fort Myers showing a sandy beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Sea School and Dunes Golf and Tennis Club are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

DiamondHead Beach Resort

DiamondHead Beach Resort

10/10 Excellent
"The resort was wonderful. The rooms were super clean, the staph were attentive, and the view of the ocean were terrific. The sand art contest was going in; but, even with all the extra people around, the service was top shelf. "
Nancy 4-night trip
Posted 3 days ago
DiamondHead Beach Resort

Explore a world of travel with Expedia

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 13 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.