Santa Clara Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to S$134 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is S$200 per night from 4 May to 5 May
S$200
4 May - 5 May
includes taxes & fees
9/10 Wonderful! (5,217 reviews)
Breakfast was really good 5 stars only negative was the pool bar and face cloths. Other than that property is beyond nice

Reviewed on 5 Apr, 2026

Hotel Riu Plaza Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is S$190 per night from 3 May to 4 May
S$190
3 May - 4 May
includes taxes & fees
8.6/10 Excellent! (1,007 reviews)
Everything was great, really nice stay

Reviewed on 6 Apr, 2026

Sheraton Grand Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is S$423 per night from 2 May to 3 May
S$423
2 May - 3 May
includes taxes & fees
8.8/10 Excellent! (1,009 reviews)
Didn’t have room for me

Reviewed on 5 Apr, 2026

W Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

What to do in Santa Clara

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.