TOP Business Hotels in Upstate South Carolina for 2026 - 𝗙𝗿𝗲𝗲 𝗖𝗮𝗻𝗰𝗲𝗹𝗹𝗮𝘁𝗶𝗼𝗻 on Select Hotels

A bench, a bicycle, and a lake surrounded by trees.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Upstate South Carolina Business Hotels

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Upstate South Carolina business-friendly hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

A pool area with lounge chairs and a sign for Best Western Plus.

A reception area with a stone counter, a laptop, and a sign indicating a Chairman's Award.

A modern kitchen with a central island, three bar stools, pendant lighting, and a decorative flower arrangement.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Stephanie

S$109

includes taxes & fees

25 Oct - 26 Oct

A multi-level hotel atrium with a central open area, multiple balconies, and a variety of seating arrangements.

A large hotel with a central courtyard, surrounded by manicured lawns and trees.

An outdoor patio area with tables and chairs, a covered seating area, and a building in the background labeled "Embassy Suites."

A spacious lobby with multiple seating areas, a glass railing overlooking a green space, and a modern interior design.

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Ethan

S$153

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio area with a fire feature, wicker furniture, and potted plants.

A conference room with a large table, green chairs, a sofa, and large windows offering a view of trees and a parking lot.

A row of Tesla electric vehicle charging stations.

A Hilton Garden Inn with a central entrance, multiple floors, and a brick facade.

3. Hilton Garden Inn Greenville

Greenville

Leroy

S$142

includes taxes & fees

31 Oct - 1 Nov

A modern kitchen with hanging light fixtures and bar seating.

A hotel patio with outdoor seating, stone pillars, and a modern building in the background.

A modern hotel room with a large desk, a comfortable sofa, and a bed.

A modern bar area with a central island, bar stools, and overhead lighting.

4. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jeffery

S$161

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

A modern hotel lobby with a wooden cabinet, a flat-screen TV, a sofa, and a table.

A fitness center with treadmills, elliptical machines, and a red exercise ball.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a red accent wall.

5. Drury Inn & Suites Greenville

Greenville

Kara

S$162

includes taxes & fees

1 Nov - 2 Nov

A hotel with a stone facade, multiple windows, and a sign indicating it's a Wyndham hotel.

A modern kitchen with a granite countertop, a built-in grill, a microwave, and a coffee maker. There are two framed artworks on the wall and a refrigerator with a built-in ice maker.

A room with a wall-mounted ATM, decorative wall panels, a window with red curtains, and a tiled floor.

A hotel room with a bed, a television, a window with curtains, and a wardrobe.

6. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Terry

S$101

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

A snack and beverage display with various snacks and drinks.

A hotel room with a large bed, a television on a dresser, a nightstand with a lamp, and a window with curtains.

A hotel pool area with lounge chairs, a flag, and a sunset view.

7. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Stephen

S$148

includes taxes & fees

29 Oct - 30 Oct

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

A modern lobby with a blue sofa, teal armchairs, hanging lights, and a seating area with round chairs.

A modern lobby with a reception desk, seating areas, and a large window offering a view.

8. Tru by Hilton Greenville Woodruff Road

Greenville

semhar

S$151

includes taxes & fees

1 Nov - 2 Nov

View all properties

Top Upstate South Carolina Hotel Reviews

Hyatt Place Greenville/Haywood

10/10 Excellent

"The room was very clean. Staff was very helpful when our key did not work. The hotel was under renovation. They did a great job at keeping it clean and quiet. My husband and granddaughter had the breakfast. They liked it. Parking was tight due to the construction. Otherwise, good. We would stay there again. Highly recommend staying here."

Comfort Inn Greenville - Haywood Mall

10/10 Excellent

"Clean room, very convenient to 385, great breakfast, nice staff, plenty of parking."

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

10/10 Excellent

"The rooms are clean and the hotel staff are friendly, Plenty of parking, Restaurants in walking distance and shopping. Hotel has been remodeled also 👍"

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent

"Very clean"

Frequently asked questions

How much do business-friendly hotels in Upstate South Carolina cost?

You can expect to pay between S$101 and S$162 per night for business-friendly hotels in Upstate South Carolina. Terrific deals on stays that are suitable for work-related travellers are a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the best business-friendly hotels in Upstate South Carolina?

That depends on your destination in Upstate South Carolina. Lots of business travellers to Greenville choose Homewood Suites by Hilton Greenville Downtown. This 3-stars property has a barbecue grill and a swimming pool. SpringHill Suites by Marriott Greenville Downtown is another excellent option if you're arranging a meeting or working remotely in Greenville. A swimming pool and a barbecue grill are some of the useful amenities at this 2.5-stars retreat. You can choose from multiple business-friendly hotels in Upstate South Carolina that have a total average guest review rating of 8.8.

How many business-friendly hotels are there in Upstate South Carolina?

When your next meeting or conference takes you someplace in Upstate South Carolina, you'll have 144 business-friendly hotels to choose from.

What are the best cheap business-friendly hotels in Upstate South Carolina?

That depends on which corner of Upstate South Carolina work is taking you. If you're headed to Greenville, SpringHill Suites by Marriott Greenville Downtown combines affordability with business-friendly amenities. A terrace and a barbecue grill are a couple of its many conveniences. On your way to Spartanburg? Look up Tru by Hilton Spartanburg. WiFi and a playground help make this cheaper property a favourite with corporate visitors. Business-friendly hotels start at just S$101 per night, so your next work trip doesn't have to stretch your finances. There are loads of fun and free things to do wherever you're headed in Upstate South Carolina. If business is taking you to Greenville, try to find time to swing by Greenville County Museum of Art. You can also go sightseeing without spending a dime in Spartanburg. Spartanburg Regional Hospital is one of the most popular free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the top business-friendly motels in Upstate South Carolina?

Expedia's business-friendly motels in Upstate South Carolina come with amenities that are the ideal mix of work and play. One of our best options is Urban Boutique Hotel, BW Signature Collection in Greenville. Located around 3 kilometres northeast of the downtown area, WiFi and front desk services are the start of its many conveniences. Another stay that appeals to corporate travellers is Days Inn by Wyndham Greenville. It's approximately 8 kilometres east of the centre of Greenville and features a swimming pool, front desk services and more.There are a ton of things to keep you entertained when you're not hard at work in Greenville. The Peace Centre and Frankie's Fun Park should be on your sightseeing checklist.

Are there any family-friendly hotels in Upstate South Carolina that are also business friendly?

You'll discover some terrific family-friendly hotels that are also business friendly in Upstate South Carolina. If you're on your way to Greenville, take a look at SpringHill Suites by Marriott Greenville Downtown. It comes with useful amenities like complimentary breakfast and WiFi and has a 2.5-stars rating. Another option to consider is Hampton Inn & Suites Greenville-Downtown-RiverPlace. This 2.5-stars stay in Greenville is perfect for both leisure and business travellers and offers complimentary breakfast, room service and more. Greenville offers loads of family-friendly attractions when you're ready to discover the sights. Frankie's Fun Park and Greenville Zoo will keep your crew entertained.

Are there any 5-star business-friendly hotels in Upstate South Carolina?

In Upstate South Carolina, 5-star business-friendly hotels are difficult to come by. However, there are some 4-star properties that cater to corporate travellers. If you're making tracks to Greenville for work, base yourself at The Westin Poinsett Greenville. It comes with handy amenities including pillow top mattresses and room service. Or, put your laptop down and feet up at Greenville Marriott, also in Greenville. Take advantage of its conveniences including a swimming pool and pillow top mattresses.

Why book your business-friendly hotel in Upstate South Carolina with Expedia?

We're here to help you find a suitable business-friendly hotel when work takes you on the road. From free parking and WiFi to gyms and on-site restaurants, our properties have the things you'll need to get the job done.

How can I find cheap business-friendly hotels in Upstate South Carolina?

When work takes you to Upstate South Carolina, our "business friendly" filter will help you find the right hotel. From WiFi to workspaces and meeting rooms, they come with the amenities you need for a productive and comfortable stay. You can also narrow your search by your preferred star rating and budget to see the most affordable properties.

What is there to do in Upstate South Carolina near my business-friendly hotel?

The most important travel accessory for your Upstate South Carolina business journey is a good itinerary for your free time! The Peace Centre, Greenville Zoo and The Children's Museum of the Upstate are some of the well-known sights if you're staying in Greenville. Spartanburg also has plenty of superb attractions, such as Spartanburg Memorial Auditorium, Spartanburg Regional History Museum and Chapman Cultural Centre.

Room 1

Change your mind

Treat yourself

Be picky

Check availability on Upstate South Carolina Business Hotels

Our top choices for Upstate South Carolina business-friendly hotels

1. Best Western Plus Greenville I-385 Inn & Suites