Upstate South Carolina Hotels from S$72
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Pet friendly
Apartยญment
Family friendly
Cottage
Condo
Waterpark
Cabin
Check prices for these dates
Tonight
23 Aug - 24 AugTomorrow
24 Aug - 25 AugNext weekend
28 Aug - 30 AugIn two weeks
4 Sept - 6 SeptOur top choices for Upstate South Carolina hotels
1. Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
Nancy
S$116
includes taxes & fees
30 Aug - 31 Aug
2. Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
Robert
S$140
includes taxes & fees
30 Aug - 31 Aug
3. Drury Inn & Suites Greenville
Drury Inn & Suites GreenvilleGreenville
Gohan
S$161
includes taxes & fees
30 Aug - 31 Aug
4. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
Cole
S$106
includes taxes & fees
26 Aug - 27 Aug
5. Hilton Greenville
Hilton GreenvilleGreenville
Gildardo
S$147
includes taxes & fees
4 Sept - 5 Sept
6. DoubleTree by Hilton Greenville Woodruff Road
DoubleTree by Hilton Greenville Woodruff RoadGreenville
JOANNA
S$160
includes taxes & fees
30 Aug - 31 Aug
7. Best Western Spartanburg I-26
Best Western Spartanburg I-26Spartanburg
Francisco
S$119
includes taxes & fees
31 Aug - 1 Sept
8. Hampton Inn Greenville I-385 - Woodruff Rd.
Hampton Inn Greenville I-385 - Woodruff Rd.Greenville
Anne
S$146
includes taxes & fees
31 Aug - 1 Sept
9. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
Microtel Inn & Suites by Wyndham Greenville / Woodruff RdGreenville
Steven
S$107
includes taxes & fees
7 Sept - 8 Sept
10. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHGSimpsonville
Alicia
S$182
includes taxes & fees
28 Aug - 29 Aug
11. Hilton Garden Inn Greenville
Hilton Garden Inn GreenvilleGreenville
Robert
S$129
includes taxes & fees
6 Sept - 7 Sept
12. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHGGreenville
Jessica
S$131
includes taxes & fees
20 Sept - 21 Sept
13. Hyatt Place Greenville Downtown
Hyatt Place Greenville DowntownGreenville Downtown
Melanie
S$188
includes taxes & fees
7 Sept - 8 Sept
14. Homewood Suites by Hilton Greenville Downtown
Homewood Suites by Hilton Greenville DowntownGreenville Downtown
Brandon
S$199
includes taxes & fees
7 Sept - 8 Sept
15. Fairfield Inn & Suites by Marriott Greenville Simpsonville
Fairfield Inn & Suites by Marriott Greenville SimpsonvilleSimpsonville
Carole
S$118
includes taxes & fees
1 Sept - 2 Sept
16. Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood MallGreenville
Marty
S$116
includes taxes & fees
6 Sept - 7 Sept
17. Embassy Suites by Hilton Greenville Downtown Riverplace
Embassy Suites by Hilton Greenville Downtown RiverplaceGreenville Downtown
LATOYA
S$224
includes taxes & fees
10 Sept - 11 Sept
18. Hampton Inn & Suites Greenville-Downtown-RiverPlace
Hampton Inn & Suites Greenville-Downtown-RiverPlaceGreenville Downtown
Layne
S$211
includes taxes & fees
3 Sept - 4 Sept
19. SpringHill Suites by Marriott Greenville Downtown
SpringHill Suites by Marriott Greenville DowntownGreenville Downtown
Douglas
S$191
includes taxes & fees
6 Sept - 7 Sept
20. Holiday Inn Express & Suites Greenville - Taylors by IHG
Holiday Inn Express & Suites Greenville - Taylors by IHGGreenville
John
S$158
includes taxes & fees
30 Aug - 31 Aug
Holiday Rentals in Upstate South Carolina
Aparthotel
stayAPT Suites Greenville-Haywood Mall
stayAPT Suites Greenville-Haywood MallGreenville
"The rooms are spacious and feels like a and apartment. This place is one of the best places to stay."
Apartment
Mint House Greenville Downtown by Kasa
Mint House Greenville Downtown by KasaGreenville Downtown
"Love the location. Room was great."
Cottage
Claires Cottage ~ 4 Mi to Downtown Greenville!
Claires Cottage ~ 4 Mi to Downtown Greenville!Greenville
"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."
Aparthotel
The Station by Compo Hotels
The Station by Compo HotelsTravelers Rest
"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."
Cabin
Carolina Camp Cedar
Carolina Camp CedarPickens
"The cottage was clean, staff was so friendly, our stay was quiet and peacefulโฆ it was perfect! Definitely planning to stay there again!"
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
"Me and my family had a great time"
Aparthotel
Landing Apartments - Lyman
Landing Apartments - LymanLyman
"Great room that was nice and clean. Smooth check-in."
Cottage
Clemson Memorabilia House
Clemson Memorabilia HouseClemson
"We enjoyed our stay, it was the perfect size for our family of four. "
Mobile Home
Carolina Landing RV Resort - Caravan Park
Carolina Landing RV Resort - Caravan ParkFair Play
"Very nice stay with friendly staff"
Cottage
Cozy Greenville Bungalow ~ 2 Mi to Downtown!
Cozy Greenville Bungalow ~ 2 Mi to Downtown!Greenville
"Amazing place. Great host. "
Apartment
Serene Travelers Rest Apartment: 7 Mi to Downtown!
Serene Travelers Rest Apartment: 7 Mi to Downtown!Travelers Rest
"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "
Cottage
Families Welcome, Fenced Yard: Inviting Greer Home
Families Welcome, Fenced Yard: Inviting Greer HomeGreer
"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."
Cottage
1 Mi to Downtown Greer: Family Home w/ Gazebo!
1 Mi to Downtown Greer: Family Home w/ Gazebo!Greer
"Very cute home close to everything. Super clean and spacious. Well furnished."
Cottage
4 Seasons of Fun! Walhalla Home w/ Spacious Yard!
4 Seasons of Fun! Walhalla Home w/ Spacious Yard!Walhalla
"The house was perfect for our group for our golf trip. We had one minor issue and we were able to speak to the host and they had someone to correct it quickly so that it didnโt disrupt our trip in any way. Place was clean, peaceful, with great hosts."
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Upstate South Carolina attractions
Clemson University
9.6/10 (1,439 reviews)
Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.
Falls Park on the Reedy
9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the great live music or attend a sporting event in this family-friendly area.
Photo by Karyn Thompson
Fred W. Symmes Chapel
9.8/10 (29 reviews)
You can find out about the history of Cleveland with a visit to Fred W. Symmes Chapel. Wander the lakeside and forests in this relaxing area.
Bon Secours Wellness Arena
8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.
Greenville Convention Center
8.4/10 (571 reviews)
Learn about the events happening in Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
Memorial Stadium
9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theatre scene or attend a football match.
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolinaโlive music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.
See all hotels in Upstate South Carolina
Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
Hyatt Regency Greenville
10/10 Excellent
"..."
Comfort Inn & Suites Clemson - University Area
8/10 Good
"Close to campus."
Best Western Plus Greenville I-385 Inn & Suites
10/10 Excellent
"X"
AC Hotel by Marriott Spartanburg
10/10 Excellent
"This is a first class property. Verry clean Verry modern our stay was short but overall impressive I would definitely satay there again"
Lakeside Lodge Clemson
10/10 Excellent
"No one under 25 allowed to check In should be changed to 21"
Hyatt Place Greenville/Haywood
10/10 Excellent
"Comfortable staying"
Comfort Suites At WestGate Mall
10/10 Excellent
"The staff was amazing! And I loved the spacious room - very clean."
Best Western Plus Clemson Hotel & Conference Center
10/10 Excellent
"This was the most enjoyable stay Iโve had in Clemson! Everything was great. I will stay here again next year!"
Hotel Hartness
10/10 Excellent
"Amazing!"
More cheap stays in Upstate South Carolina
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
S$84
2 Sept - 3 Sept
includes taxes & fees
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
S$116
30 Aug - 31 Aug
includes taxes & fees
9.2/10 Wonderful! (1,570 reviews)
Comfort Inn Greenville - Haywood Mall
246 Congaree Road Greenville SC
S$116
6 Sept - 7 Sept
includes taxes & fees
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
161 Sha Ln Spartanburg SC
S$131
20 Sept - 21 Sept
includes taxes & fees
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
S$143
26 Aug - 27 Aug
includes taxes & fees
8/10 Very good! (1,038 reviews)
Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
S$172
24 Aug - 25 Aug
includes taxes & fees
9/10 Wonderful! (1,008 reviews)
Hotels in Upstate South Carolina with star rating
4 Star Hotels
29 properties
3 Star Hotels
204 properties
2 Star Hotels
155 properties
Explore a world of travel with Expedia
- 4 Star Hotels in Greenville
- Hotels near Bon Secours Wellness Arena
- Campobello Hotels
- Clemson Hotels
- Hotels near Clemson University
- Cleveland Hotels
- Gay friendly Hotels in Colonel Elias Earle Historic District
- Duncan Hotels
- Easley Hotels
- Enoree Hotels
- Fountain Inn Hotels
- Gay friendly Hotels in Green Avenue
- Apartments in Greenville
- B&B in Greenville
- Oyo Rooms Hotels in Greenville Downtown
- Greenville Downtown Hotels
- Farmstay in Greenville
- Boutique Hotels in Greenville
- Budget Hotels in Greenville
- Hotels with Bars / Lounges in Greenville
- Hotels with free airport shuttle in Greenville
- Greenville Hotels
- Motels in Greenville
- Hotels with Airport Shuttle in Greenville - Spartanburg
- Hotels with free airport shuttle in Greenville - Spartanburg
- Hotels with smoking rooms in Greenville - Spartanburg
- Hotels near Greenville-Spartanburg Intl.
- Hotels near Greenville Technical College
- Laurens Hotels
- Liberty Hotels
- Marietta Hotels
- Aparthotels in Mauldin
- Northlake Hotels
- Gay friendly Hotels in Payne-Logan
- Pelzer Hotels
- Pendleton Hotels
- Roebuck Hotels
- Simpsonville Hotels
- Spartanburg Hotels
- Sunset Hotels
- Hotels near The Peace Center
- Hotels near Tyger River Park
- Welcome Hotels
- Hotels near WestGate Mall
- Hotels near Wofford College
- Woodruff Hotels
- Flights to Greenville - Spartanburg
- Flights to Greenville
- Flights to Upstate South Carolina
- Flights from Donaldson Center
- Flights from Greenville Downtown
- Flights from Piedmont
- Flights from Dunean
- Flights from Greenville - Spartanburg
- Flights from Simpsonville
- Flights from Atlanta (ATL) to Greenville (GDC)
- Flights from Asheville (AVL) to Greenville (GMU)
- Flights from Bridgeport (BDR) to Greenville (GMU)
- Flights from Boston (BOS) to Greenville (GDC)
- Flights from Clemson (CEU) to Greenville (GDC)
- Flights from Cleveland (CGF) to Greenville (GMU)
- Flights from Rome (FCO) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GMU)
- Flights from Wilmington (ILM) to Greenville (GSP)
- Flights from New York (JFK) to Greenville (GDC)
- Flights from New York (JFK) to Greenville (GMU)
- Flights from Lansing (LAN) to Greenville (GMU)
- Flights from Los Angeles (LAX) to Greenville (GMU)
- Flights from Los Angeles (LAX) to Greenville (GSP)
- Flights from New York (LGA) to Greenville (GMU)
- Flights from Memphis (MEM) to Greenville (GSP)
- Flights from Smyrna (MQY) to Greenville (GMU)
- Flights from New York (NYC) to Greenville (GSP)
- Flights from Chicago (ORD) to Greenville (GDC)
- Flights from Norfolk (ORF) to Greenville (GDC)
- Flights from Princeton (PCT) to Greenville (GMU)
- Flights from Punta Gorda Airport (PGD) to Greenville (GMU)
- Flights from Fort Myers (RSW) to Greenville (GSP)
- Flights from San Francisco (SFO) to Greenville (GSP)
- Flights from Singapore (SIN) to Greenville (GSP)
- Flights from Syracuse (SYR) to Greenville (GDC)
- Flights from Tuscaloosa (TCL) to Greenville (GMU)
- Flights from Montreal (YUL) to Greenville (GMU)
