A bench, a bicycle, and a lake surrounded by trees.

Find Upstate South Carolina Spa Hotels from S$234

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina Hotels with Spa

Tonight
21 Oct - 22 Oct
Tomorrow
22 Oct - 23 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Upstate South Carolina hotels with a spa

A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A cozy lounge area with leather armchairs, a central table, and a fireplace.
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A modern interior with a large window, a chandelier, a dining area, and a hallway leading to a door.

1. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
S$280
includes taxes & fees
25 Oct - 26 Oct
Hotel Hartness
A spa room with two beds, a mural, and a reception desk.
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
S$507
includes taxes & fees
15 Nov - 16 Nov
Grand Bohemian Lodge Greenville, Autograph Collection
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.
A reception area with a wooden reception desk, a large abstract painting, and a potted plant.

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
S$589
includes taxes & fees
25 Oct - 26 Oct
Hotel Domestique
Exterior
Terrace/patio
Interior
Interior

4. Bed & Breakfast on Tiffany Hill

Bed & Breakfast on Tiffany Hill
Mills River
S$406
includes taxes & fees
8 Nov - 9 Nov
Bed & Breakfast on Tiffany Hill
A large, two-story building with a stone facade and a spacious lawn with lounge chairs.
A covered porch with wicker furniture, a ceiling fan, and potted plants.
A cozy living room with a fireplace, comfortable seating, and a dining area.
A restaurant with round tables covered with white tablecloths, dark wooden chairs, and candles on coasters.

5. Echo Mountain Inn

Echo Mountain Inn
Hendersonville
  • Experience mountain tranquility at this charming bed and breakfast, where spa services and garden views create a serene wellness retreat.
S$199
includes taxes & fees
17 Nov - 18 Nov
Echo Mountain Inn
A hotel room with two beds, a desk, a chair, a mirror, and a window with curtains.
A bedroom with a bed, a ceiling fan, a bedside table, and a nightstand.
A dining area with checkered flooring, multiple tables and chairs, and a decorative cabinet with various items.
A covered porch with a view of a street, two potted plants, and an American flag.

6. 1898 Waverly Inn

1898 Waverly Inn
Hendersonville
  • Experience spa bliss at this charming B&B with relaxing massage treatment rooms and attentive staff who ensure a rejuvenating stay.
S$234
includes taxes & fees
3 Nov - 4 Nov
1898 Waverly Inn
A hotel room with a bed, a bedside lamp, and a small table with candles.
A spacious dining area with multiple tables and chairs, large windows, and ornate chandeliers.
A swimming pool with lounge chairs and umbrellas, surrounded by autumn trees and a lake view.
A stone staircase leading to a house with a stone chimney and a small glass door.

7. Greystone Inn

Greystone Inn
Lake Toxaway
  • Soak in mountain views at this lakeside retreat with couples' spa treatment rooms, yoga classes, and deep-tissue massages.
S$513
includes taxes & fees
22 Nov - 23 Nov
Greystone Inn
A two-story wooden cabin with a balcony, a swimming pool, and a deck area.
A two-story wooden house with a porch, surrounded by dense forest.
A wooden interior with tables and chairs, a fireplace, and a stone wall.
A cozy room with a bed, a chair, a tray with snacks and wine, and a view of the outdoors.

8. Glen-Ella Springs Hotel & Restaurant

Glen-Ella Springs Hotel & Restaurant
Clarkesville
  • Relaxing country retreat with in-room massages and a serene garden setting for a rejuvenating spa experience.
S$308
includes taxes & fees
22 Nov - 23 Nov
Glen-Ella Springs Hotel & Restaurant
A reception desk with a logo above it, a white bust sculpture, and a vase with pampas grass.
A modern kitchen with white cabinets, a stainless steel sink, and a wooden staircase leading to a balcony.
A modern kitchen with a central island, a dining area with a table and chairs, and a staircase leading to an upper level.
A bedroom with a bed, a nightstand, a lamp, and a view of a balcony with outdoor furniture.

9. SKYLARANNA Resort & Spa

SKYLARANNA Resort & Spa
Hendersonville
  • Rejuvenate in a mountain spa retreat with 3 dedicated treatment rooms, hot tubs, and aromatherapy services along a scenic river.
S$236
includes taxes & fees
25 Oct - 26 Oct
SKYLARANNA Resort & Spa
A round table set for four with wicker chairs, a white tablecloth, and a view of a forested area through large windows.
A cozy living room with a large window, a fireplace, and various plants.
A bathroom with a shower area, a toilet, and a sink.
A bedroom with two beds, wooden headboard panels, and a window with a view.

10. Sylvan Falls Mill B&B

Sylvan Falls Mill B&B
Rabun Gap
  • Serene mountain retreat offers restorative massages in a garden setting, steps away from Chattahoochee National Forest.
S$301
includes taxes & fees
29 Oct - 30 Oct
Sylvan Falls Mill B&B
View all properties

Choose what matters most at spa hotels in Upstate South Carolina

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Upstate South Carolina Hotel Reviews

Explore a world of travel with Expedia