S$383 Cheap Flights from Des Moines to Key West

View S$383 flight on Tue, 25 Nov, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Key West Intl. Airport (EYW)

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Cheap Flights from Des Moines to Key West (DSM-EYW)

Prices were available within the past 7 days and start at S$383 for one-way flights and S$453 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$453 Return, found 9 hours ago
S$453
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$453 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$493 Return, found 9 hours ago
S$493
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$493 found 9 hours ago
American Airlines
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$501 Return, found 9 hours ago
S$501
Return
found 9 hours ago
Select American Airlines flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$501 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$531 Return, found 9 hours ago
S$531
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$531 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$557 Return, found 9 hours ago
S$557
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$557 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$596 Return, found 9 hours ago
S$596
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$596 found 9 hours ago
American Airlines
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$627 Return, found 9 hours ago
S$627
Return
found 9 hours ago
Select American Airlines flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$627 found 9 hours ago
American Airlines
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$631 Return, found 9 hours ago
S$631
Return
found 9 hours ago
Select American Airlines flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$631 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$635 Return, found 9 hours ago
S$635
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$635 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$651 Return, found 9 hours ago
S$651
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$651 found 9 hours ago
Delta
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$674 Return, found 9 hours ago
S$674
Return
found 9 hours ago
Select Delta flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$674 found 9 hours ago
American Airlines
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$675 Return, found 9 hours ago
S$675
Return
found 9 hours ago
Select American Airlines flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$675 found 9 hours ago
United
Tue, 25 Nov - Tue, 2 Dec
DSM
Des Moines
EYW
Key West
S$694 Return, found 9 hours ago
S$694
Return
found 9 hours ago
Select United flight, departing Tue, 25 Nov from Des Moines to Key West, returning Tue, 2 Dec, priced at S$694 found 9 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Key West (EYW)

May is typically the cheapest month to fly

From S$340 - S$816 per traveller.

Frequently asked questions

How much is a flight from Des Moines Intl. Airport to Key West Intl. Airport (EYW)?
Within the past 7 days on Expedia, for flights departing within the next year, the lowest price listed for a round-trip flight from Des Moines Intl. Airport to Key West Intl. Airport (EYW) was S$453. Cheap fares don't hang around forever, so make sure you book yours ASAP. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Des Moines Intl. Airport to Key West Intl. Airport (EYW)?
Every air carrier has its own set of terms and conditions. If you do decide to cancel, follow the simple instructions on our Customer Service Portal.
How do I find cheap flights from DSM to Key West Intl. Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for DSM to Key West Intl. Airport (EYW) flights, you'll see a "no change fees" filter for you to select.
How far is the flight from Des Moines Intl. Airport to EYW?
The flight distance from DSM to EYW is 2,200 kilometres. Pack yourself a drink, a few snacks and something to read. Keep yourself busy in the air and the hours will fly by.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to Key West Intl. Airport?
Flying directly between Des Moines Intl. Airport (DSM) and Key West Intl. Airport (EYW) isn't possible at the moment. However, you'll still be able to find a flight to Key West with at least one stop.
Are DSM to Key West Intl. Airport (EYW) flight tickets cheaper when they're purchased at the last minute?
Booking last minute from Des Moines Intl. Airport to EYW can be hit-or-miss. You may be able to score a bargain, but then again, you could miss out altogether! If you'd rather play it safe and start your travel planning early on, Expedia compares flight deals up to a year in advance. Just bear in mind that not all airlines publish their prices so far in advance. Our top tip? Check back often as prices are updated frequently.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Key West Intl.
Airlines serving
American Airlines, Delta, United
Return price
S$452
Distance
2171 km

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Perfect flights from Des Moines to Key West

Your Journey from Des Moines to Key West

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Experience the Vibrant Key West

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*Note: Prices may vary based on availability and are subject to change.
Perfect flights from Des Moines to Key West

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