There are several airlines that operate frequent flights from San Francisco (SFO) to Milan (MXP) including

• United Airlines with 66 flights a week
• Delta Air Lines with 48 flights a week
• American Airlines with 45 flights a week
• Lufthansa Cargo with 44 flights a week
• Air France with 41 flights a week

The earliest flight leaves San Francisco Intl. Airport at 06:00 and arrives at Malpensa Intl. Airport at 07:00. The last flight of the day departs San Francisco at 21:55 and arrives at Milan at 23:45.

The flight distance from San Francisco to Milan is about 10198 km, the shortest flight is 13 hours with Virgin Atlantic.

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