What is Downtown West like?

Travellers are sure to enjoy a stay in St. Louis's Downtown West neighbourhood. Experience the best of Downtown West with a visit to St. Louis Union Station and Enterprise Center during your trip.

Where is the best hotel for a stay in Downtown West?

Based on our traveller data, 21C Museum Hotel St Louis is one of the top choices for your stay in Downtown West. This hotel is a short 8-minute walk from Enterprise Center, and it offers a restaurant and an indoor pool. Other good choices for your stay in the neighbourhood include Drury Plaza Hotel St. Louis Union Station and Pear Tree Inn St. Louis Near Union Station .

How many hotels will I find in the Downtown West area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 35 Downtown West hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Downtown West, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within 24 hours of your booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to review top deals in Downtown West.

What is there to do in this St. Louis neighbourhood?

You can check out a show at Peabody Opera House, Stifel Theatre and The Hawthorn while you're in Downtown West. St. Louis Union Station and Enterprise Center are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Downtown West include Whispering Arch at Union Station, St. Louis Aquarium at Union Station and St. Louis Union Station Mini Golf. While you're out sightseeing, The St. Louis Wheel and Energizer Park are a couple of additional sights to visit in St. Louis.

How can I get around Downtown West and the greater St. Louis area?

To venture out of town, take a train from St. Louis Gateway Station.

Top 10 Downtown West Hotels of 2026

An ornate hall with arched ceilings and intricate patterns.

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Our top choices for Downtown West hotels

An indoor pool area with a hot tub, seating, and a stone wall.

1. Drury Plaza Hotel St. Louis Union Station

Downtown West

Robert

includes taxes & fees

4 Oct - 5 Oct

A modern bar area with a wooden bar counter, black bar stools, and a large wall with city names.

2. Fairfield Inn & Suites by Marriott St. Louis Downtown

Downtown West

James

includes taxes & fees

5 Oct - 6 Oct

A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

3. 21C Museum Hotel St Louis

Downtown West

Zane

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with high arched ceilings, ornate columns, and a central fountain.

4. St. Louis Union Station Hotel, Curio Collection by Hilton

Downtown West

Mirjana

includes taxes & fees

27 Oct - 28 Oct

An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

5. Pear Tree Inn St. Louis Near Union Station

Downtown West

Michael

includes taxes & fees

4 Oct - 5 Oct

A modern kitchen with a hexagonal tile backsplash, built-in appliances, and a central island.

6. Tru By Hilton St. Louis Downtown

Downtown West

Shonda

includes taxes & fees

6 Oct - 7 Oct

A modern outdoor seating area with a fire pit, surrounded by wicker furniture and a landscaped garden.

7. Courtyard by Marriott St. Louis Downtown West

Downtown West

Jonathan

includes taxes & fees

7 Oct - 8 Oct

A modern interior with hanging chairs and ottomans, large windows with a view of the street.

8. Home2 Suites by Hilton St. Louis Downtown

Downtown West

Erik

includes taxes & fees

8 Oct - 9 Oct

A rooftop terrace with wicker furniture, offering a city view.

9. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 1.7 km from Downtown West

Salvatore

includes taxes & fees

2 Oct - 3 Oct

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

10. Hyatt Regency St. Louis at The Arch

Downtown St. Louis, 1.7 km from Downtown West

David

includes taxes & fees

2 Oct - 3 Oct

A multi-story building with a classic architectural style, featuring numerous windows and a brick facade.

11. Courtyard by Marriott St. Louis Downtown/Convention Center

Downtown St. Louis, 1.2 km from Downtown West

Kristy

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

12. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis, 1.4 km from Downtown West

Karen

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.

13. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Downtown St. Louis, 1.8 km from Downtown West

Andy

includes taxes & fees

26 Oct - 27 Oct

A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

14. Live by Loews - St.Louis

Downtown St. Louis, 1.3 km from Downtown West

Frank

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with modern seating arrangements, a large chandelier, and a view of the cityscape through large windows.

15. Hilton Pennywell St. Louis at the Arch

Downtown St. Louis, 1.6 km from Downtown West

Gemma

includes taxes & fees

11 Oct - 12 Oct

A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.

16. The Westin St. Louis

Downtown St. Louis, 1.3 km from Downtown West

Joanne

includes taxes & fees

18 Oct - 19 Oct

A rooftop terrace with outdoor seating, string lights, and a city skyline view.

17. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

2.3 km from Downtown West

Skylee

includes taxes & fees

5 Oct - 6 Oct

A spacious lobby with a polished floor, a large chandelier, and a central table with a potted plant.

18. Missouri Athletic Club

Downtown St. Louis, 1.7 km from Downtown West

Heather

includes taxes & fees

2 Oct - 3 Oct

An indoor swimming pool with a glass ceiling, surrounded by potted plants and a tiled wall with a geometric pattern.

19. Casino Queen Hotel

2.7 km from Downtown West

Shawna

includes taxes & fees

29 Sept - 30 Sept

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

20. Comfort Inn & Suites Saint Louis Lafayette Square

The Gate, 2.1 km from Downtown West

Daevontae

includes taxes & fees

29 Oct - 30 Oct

View all properties

Compare popular hotels in Downtown West

Property	Property class	Guest rating
Drury Plaza Hotel St. Louis Union Station	3.0 star property	9.4 Exceptional 1,558 reviews	View
Fairfield Inn & Suites by Marriott St. Louis Downtown	3.0 star property	9.2 Wonderful 1,002 reviews	View
21C Museum Hotel St Louis	4.5 star property	9.0 Wonderful 2,124 reviews	View
Pear Tree Inn St. Louis Near Union Station	3.0 star property	8.8 Excellent 2,213 reviews	View
St. Louis Union Station Hotel, Curio Collection by Hilton	4.0 star property	8.8 Excellent 1,014 reviews	View

Where to stay in Downtown West

Find the best Downtown West areas for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch National Park to Kiener Plaza – discover Downtown St. Louis, a destination also famous for its historic sites.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

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A fountain in front of a red brick building with green roofs and white trim.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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Top Downtown West Hotel Reviews

Home2 Suites by Hilton St. Louis Downtown

8/10 Good

"Clean rooms, friendly helpful staff, nice complimentary breakfast and nighttime security make this hotel an incredible value. The location is great too. The beds and pillows are not comfortable but they were very clean. This is not really an issue if traveling for business. I recommend this property."