Hotels in Clayton

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Clayton hotels

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
9.0 out of 10, Wonderful, (3,170 reviews)
"This is an older property, but very clean, comfortable, spacious and convenient to downtown Clayton. Parking was convenient and free on the weekend. Breakfast was better than average, with chef-made omelets and waffles. "
United States
Linda
The price is S$148
includes taxes & fees
17 May - 18 May
Clayton Plaza Hotel & Extended Stay

AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton
3.0 star property
Clayton
9.0 out of 10, Wonderful, (292 reviews)
"Excellent overall. Perfect location in downtown Clayton, conveniently next to Shaw Parking Garage. Staff is good, rooms are great and clean, simple and elegant."
United States
Samuel
The price is S$201
includes taxes & fees
10 May - 11 May
AC Hotel St. Louis Clayton

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (565 reviews)
"Great property. Concierge level wonderful. "
United States
Mike
The price is S$743
includes taxes & fees
3 May - 4 May
The Ritz-Carlton, St. Louis

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Clayton
8.4 out of 10, Very good, (588 reviews)
"Great boutique hotel, bar and dining. Perfect location to explore Clayton, with many restaurants and a grocery nearby. I’ll book again the next time I’m in town. "
United States
David B.
The price is S$260
includes taxes & fees
8 May - 9 May
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (711 reviews)
"Great stay! Beautifiul hotel and room!!"
United States
Stephen
The price is S$203
includes taxes & fees
10 May - 11 May
Le Méridien St. Louis Clayton

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
3.0 star property
Clayton
9.0 out of 10, Wonderful, (971 reviews)
"Pleasant and professional staff. Updated property and was incredibly clean!"
United States
Bradley
The price is S$196
includes taxes & fees
10 May - 11 May
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Residence Inn By Marriott St. Louis Clayton

Residence Inn By Marriott St. Louis Clayton
3.0 star property
Clayton
9.4 out of 10, Exceptional, (214 reviews)
"Came to town for just a spring break getaway, I just want to let everyone know the staff at this hotel is phenomenal. From the moment I walked in into the moment I left they are all so friendly and just make you feel welcome. The hotel itself is beautiful and it’s very clean and comfortable. I would definitely stay here again."
United States
Erica
The price is S$267
includes taxes & fees
10 May - 11 May
Residence Inn By Marriott St. Louis Clayton

Homewood Suites by Hilton St Louis - Galleria

Homewood Suites by Hilton St Louis - Galleria
3.0 star property
Clayton
7.8 out of 10, Good, (1,000 reviews)
"Shay at the front desk was so welcoming and amazing!! Truly an asset to the hotel!! "
United States
Deborah
The price is S$199
includes taxes & fees
3 May - 4 May
Homewood Suites by Hilton St Louis - Galleria

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 12 km from Clayton
8.6 out of 10, Excellent, (4,019 reviews)
"Beautiful hotel. Staff helpful. Very clean. Great location."
United States
Dawn
The price is S$190
includes taxes & fees
25 May - 26 May
Hyatt Regency St. Louis at The Arch

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
19.8 km from Clayton
8.4 out of 10, Very good, (1,005 reviews)
"Excellent place to stay on our trip West. Rooms are amazing and spacious, great river view. Quiet, clean and comfortable. Good, safe location and much to do. Easy parking and very friendly staff. Great restaurant choices. We will be back."
United States
Terri Sue
The price is S$258
includes taxes & fees
11 May - 12 May
Ameristar Casino Resort and Spa

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 11.9 km from Clayton
9.4 out of 10, Exceptional, (3,392 reviews)
"clean rooms, GREAT complimentary breakfast, dinner and snacks. love this place will be back soon!!"
United States
Maria
The price is S$246
includes taxes & fees
3 May - 4 May
Drury Plaza Hotel St. Louis at the Arch

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center
3.0 star property
Downtown St. Louis, 11.5 km from Clayton
9.0 out of 10, Wonderful, (1,003 reviews)
"We stayed overnight room was spacious clean upon check in staff was very welcoming i would definitely come back!!"
United States
brenda
The price is S$188
includes taxes & fees
27 May - 28 May
Courtyard by Marriott St. Louis Downtown/Convention Center

Live by Loews - St.Louis

Live by Loews - St.Louis
4.0 star property
Downtown St. Louis, 11.5 km from Clayton
9.4 out of 10, Exceptional, (1,171 reviews)
"Awesome location, super clean, excellent staff! Will be back for our next stay in St Louis!"
United States
James
The price is S$241
includes taxes & fees
7 May - 8 May
Live by Loews - St.Louis

The Principal Hotel

The Principal Hotel
3.5 star property
24.9 km from Clayton
9.8 out of 10, Exceptional, (250 reviews)
"Cute, super clean property- would stay here again if visiting stl area !! Highly recommend "
United States
Paulina
The price is S$158
includes taxes & fees
28 Apr - 29 Apr
The Principal Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis, 11.5 km from Clayton
8.8 out of 10, Excellent, (1,269 reviews)
"Really good choice for the area. The room was very comfortable and relaxing. Good helpful staff. Not a lot of restaurants within a 4 block radius but enough to eat. St. Louis is just that way. "
United States
Andrew
The price is S$174
includes taxes & fees
24 May - 25 May
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West, 10.6 km from Clayton
9.0 out of 10, Wonderful, (1,793 reviews)
"Beautiful place, friendly staff! Enjoyed our stay and will definitely come back!!!"
United States
Mike
The price is S$233
includes taxes & fees
28 May - 29 May
21C Museum Hotel St Louis

Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
3.0 star property
2.5 km from Clayton
9.6 out of 10, Exceptional, (1,002 reviews)
"Clean. Close by. Great breakfast "
United States
Anne
The price is S$245
includes taxes & fees
10 May - 11 May
Drury Plaza Hotel St. Louis Brentwood

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
16.7 km from Clayton
8.0 out of 10, Very good, (1,238 reviews)
"Nice rooms. They were clean but had a musty smell. Right next to Cracker Barrel which was nice!! "
United States
Renee
The price is S$131
includes taxes & fees
17 May - 18 May
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
13.6 km from Clayton
9.0 out of 10, Wonderful, (1,527 reviews)
"Loved the terrace room!! "
United States
Penny
The price is S$174
includes taxes & fees
29 Apr - 30 Apr
River City Casino & Hotel

Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport
3.0 star property
11.1 km from Clayton
9.2 out of 10, Wonderful, (1,206 reviews)
"very much enjoyed breakfast selections and happy hour. everyone very friendly. first time to st Louis, this made great impression."
United States
Tameika
The price is S$172
includes taxes & fees
10 May - 11 May
Drury Inn & Suites St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Clayton

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Property amenity
Residence Inn By Marriott St. Louis Clayton
3.0 star property
9.4
Exceptional
214 reviews
View
Meeting facility
The Ritz-Carlton, St. Louis
5.0 star property
9.2
Wonderful
565 reviews
View
Property amenity
AC Hotel St. Louis Clayton
3.0 star property
9.0
Wonderful
292 reviews
View
Exterior
Clayton Plaza Hotel & Extended Stay
3.5 star property
9.0
Wonderful
3,170 reviews
View
Outdoor dining
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
3.0 star property
9.0
Wonderful
971 reviews
View

Where to stay in Clayton

Find the best Clayton areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Top Clayton Hotel Reviews

Frequently asked questions

What's it like in Clayton?
Clayton is a welcoming neighbourhood known for its array of dining options and sporting events. Make sure that you visit Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center as part of your Clayton travel plans.
Where is the best place to stay in Clayton?
Based on our traveller data, Clayton Plaza Hotel & Extended Stay is one of the top choices for your stay in Clayton. This hotel offers free breakfast and an indoor pool. Other good choices for your stay in the neighbourhood include The Ritz-Carlton, St. Louis and AC Hotel St. Louis Clayton.
How many hotels will I find in Clayton?
Expedia has 20 hotels and other accommodation options in Clayton to choose from, making this an ideal home base for exploring the greater St. Louis area.
If I need to cancel my hotel reservation in Clayton, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the top deals on offer in Clayton.
What are the top things to see and do in Clayton?
A few attractions you might want to check out while you're in Clayton are Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. When you're sightseeing in St. Louis, St. Louis Zoo and Tao Tennis Center are also worth a stop.
How can I get around Clayton and the greater St. Louis area?
Ready to get out and explore the city? Clayton Station is the closest metro station.

Explore a world of travel with Expedia