What's it like in Guadalupe District?

You'll be sure to have fun exploring Santa Fe's Guadalupe District neighbourhood. Make sure that you visit Santa Fe Railyard and Santa Fe Farmers Market as part of your Guadalupe District travel plans.

How many hotels are there in the Guadalupe District area?

If you're searching for places to stay in Santa Fe, Expedia has something to meet your needs with 72 Guadalupe District hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Guadalupe District, will I receive a refund?

Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to get the best options available in Guadalupe District.

What can I see and do in this Santa Fe neighbourhood?

Sights like El Museo Cultural, Art Vault and TAI Modern can be part of your cultural tour of Guadalupe District. As you're discovering the neighbourhood, Santa Fe Railyard and Santa Fe Farmers Market are some other places worth a visit. SITE Santa Fe, Santuario De Nuestra Senora de Guadalupe and Andrea Fisher Fine Pottery are just a few of the places to visit in and around Guadalupe District. While you're out sightseeing, Lensic Performing Arts Center and Georgia O'Keefe Museum are a couple of additional sights to visit in Santa Fe.

How can I get around Guadalupe District and the greater Santa Fe area?

If you want to head out of town, you can hop aboard a train at Santa Fe Depot.

Top 10 Guadalupe District Hotels of 2026

A train station with tracks, a Santa Fe Railway building, and wooden poles.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Guadalupe District hotels

A bathroom with a freestanding bathtub, a wooden vanity with a mirror, and a blue-tiled wall.

1. Guadalupe Inn

Guadalupe District

George

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, green walls, and a wooden floor.

2. Motel 6 Santa Fe, NM - Downtown

Railyard Arts District, 0.5 km from Guadalupe District

Mark

includes taxes & fees

26 Oct - 27 Oct

An outdoor seating area with wicker furniture, red cushions, and a central fire feature.

3. The Sage Hotel

Don Diego, 0.6 km from Guadalupe District

Martha

includes taxes & fees

20 Oct - 21 Oct

A wooden deck with chairs and a view of buildings.

4. The Inn at Vanessie

West Guadaloupe, 0.6 km from Guadalupe District

Tracy

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a wooden headboard, two bedside lamps, a bed with white linens, a colorful rug, and a framed sign on the wall.

5. The Parador

Downtown Santa Fe, 0.7 km from Guadalupe District

Sabrina

includes taxes & fees

28 Oct - 29 Oct

An outdoor patio with a rustic wooden ceiling, a brick floor, and a stone fireplace.

6. Santa Fe Motel & Inn

Railyard Arts District, 0.5 km from Guadalupe District

Jeff

includes taxes & fees

30 Oct - 31 Oct

A cozy room with a fireplace, leather sofa, wooden table, and a chair.

7. Las Palomas

West Guadaloupe, 0.6 km from Guadalupe District

David

includes taxes & fees

27 Oct - 28 Oct

A hotel with a pool, a parking lot, and a sunset view.

8. El Sendero Inn, an Ascend Collection Hotel

Downtown Santa Fe, 1.2 km from Guadalupe District

Robert

includes taxes & fees

25 Oct - 26 Oct

A cozy living room with a leather sofa, wooden cabinet, and a large window with a view.

9. Piñon Court By La Fonda

Downtown Santa Fe, 0.7 km from Guadalupe District

Christine

includes taxes & fees

29 Oct - 30 Oct

An outdoor patio area with string lights, a red umbrella, and a brick pathway.

10. Pueblo Bonito Inn

Downtown Santa Fe, 0.8 km from Guadalupe District

Christine

includes taxes & fees

29 Oct - 30 Oct

A cozy interior with a view of the landscape, featuring a seating area with round tables and cushioned chairs, wooden beams on the ceiling, and a green wall.

11. Hotel Glorieta

1.6 km from Guadalupe District

Sarah

includes taxes & fees

26 Oct - 27 Oct

An open door leading to a balcony with a table set for two, a fireplace, and a view of trees.

12. Inn of the Governors

Downtown Santa Fe, 0.9 km from Guadalupe District

jackie

includes taxes & fees

25 Oct - 26 Oct

An entrance to a bar with a sign reading "SECRETO BAR" above the door.

13. Hotel St Francis

Downtown Santa Fe, 0.9 km from Guadalupe District

Denzel

includes taxes & fees

18 Oct - 19 Oct

A modern building with a covered patio area, large windows, and a well-maintained garden.

14. The Hacienda & Spa at Hotel Santa Fe

Railyard Arts District, 0.4 km from Guadalupe District

Savion

includes taxes & fees

8 Oct - 9 Oct

A hotel room with a bed, a nightstand with a lamp, a television, and a bathroom with a sink and mirror.

15. Holiday Inn Express & Suites Santa Fe by IHG

Southside, 6.3 km from Guadalupe District

Desiree

includes taxes & fees

29 Oct - 30 Oct

A rooftop pool area with lounge chairs and a hot tub, surrounded by buildings and a view of the mountains.

16. Eldorado Hotel & Spa

Downtown Santa Fe, 0.8 km from Guadalupe District

Amy

includes taxes & fees

18 Oct - 19 Oct

A restaurant with outdoor seating, a white fence, and a signboard.

17. Hotel Chimayo de Santa Fe

Downtown Santa Fe, 1.2 km from Guadalupe District

Vina

includes taxes & fees

25 Oct - 26 Oct

A building with a green door, a number '10' sign, and a street view with a tree and a building in the background.

18. King's Rest Court Inn

Southside, 2.3 km from Guadalupe District

Linda

includes taxes & fees

13 Oct - 14 Oct

A bar area with a high counter, stools, and a variety of bottles and glasses.

19. Drury Plaza Hotel in Santa Fe

Downtown Santa Fe, 1.4 km from Guadalupe District

Simon

includes taxes & fees

7 Oct - 8 Oct

A building with a white facade partially covered by green ivy. There is a staircase leading to an entrance, and a cactus plant in the foreground.

20. El Rey Court

Midtown, 3.2 km from Guadalupe District

Robert

includes taxes & fees

25 Oct - 26 Oct

View all properties

Where to stay in Guadalupe District

Find the best Guadalupe District areas for the activities you enjoy most.

A building with a distinctive architectural style, featuring a tower and a covered entrance.

Downtown Santa Fe

Visitors to Downtown Santa Fe rave about its fascinating museums, popular shops and acclaimed art galleries. You might also want to make some time to see Lensic Performing Arts Center or Georgia O'Keefe Museum while you're exploring the neighbourhood.

See properties

A building with the sign 'Palace of the Governors' and flags hanging overhead.

Southside

Southside is known for its popular shops, and with sights like Meow Wolf and Regal Santa Fe Place, you won't get bored spending a day wandering around this part of Santa Fe.

See properties

A Turner Carroll Gallery with a red door and a metal roof.

Historic Eastside

While visiting Historic Eastside, you might make a stop by sights like Canyon Road and Skateboard Park.

See properties

A church with two bell towers and a large circular window.

Northeast Santa Fe

While Northeast Santa Fe isn't home to many top sights, New Mexico Museum of Art and Cathedral Basilica of Saint Francis of Assisi are some notable places to visit nearby.

See properties

A performer in a white costume with a mask on a stage with fire effects.

North Hills

While there might not be top attractions in North Hills, you can explore the larger area and discover places like Skateboard Park and Canyon Road.

See properties

Top Guadalupe District Hotel Reviews

Hotel Chimayo de Santa Fe

8/10 Good

"Great location but it’s very out of date. The heat is on one main control with the hotel. So if the heat is on it’s on in every room. The rooms could have been cleaner."