Serra Mesa
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
One of America’s largest urban green spaces, Balboa Park is an exciting spot packed with art, culture, and a world-renowned zoo.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
San Diego Old Town Trolley Hop-On Hop-Off Tour
San Diego City Lights Night Tour
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
San Diego Whale Watching Cruise
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
Top hotels in Serra Mesa
Sheraton San Diego Resort
Very nice room
Reviewed on 13 Jan, 2026
Bay Club Hotel & Marina
Clean room, great little restaurant and bar, friendly staff
Reviewed on 13 Jan, 2026
The DEXTRO Little Italy, BW Premier Collection
Great staff, nicely designed, convenient location.
Reviewed on 12 Jan, 2026
Courtyard by Marriott San Diego Downtown Little Italy
i had an early check-in and received an upgraded room!! amazing staff!
Reviewed on 12 Jan, 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
Room was excellent. Very comfortable. I love the friendliness of the staff and the location does not get any better than this. the Trolley is right across the street, (a 5 minute walk). You can get to literally "any place" you need to go in San Diego from the trolley. I will definitely stay here ...
Reviewed on 13 Jan, 2026
Hilton San Diego Mission Valley
It was nice but plain. The room needed puctures or posters for color.
Reviewed on 11 Jan, 2026
Other neighbourhoods around Serra Mesa
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
Old Town San Diego
The abundant dining options and seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
