𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southeast Missouri from S$81 (2026) - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

1. Drury Inn & Suites Jackson MO

Jackson

Jamie

S$117

includes taxes & fees

17 Sept - 18 Sept

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

2. Fort Davidson Hotel

Ironton

richard

S$173

includes taxes & fees

8 Sept - 9 Sept

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A hotel room with two beds, a lamp, and a painting on the wall.

A building with a red awning labeled "Shepherd Mountain Inn."

3. Shepherd Mountain Inn

Ironton

Katie

S$171

includes taxes & fees

28 Aug - 29 Aug

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

4. Madison Inn Lodge

Fredericktown

Melissa

S$121

includes taxes & fees

8 Sept - 9 Sept

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

5. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Matthew

S$143

includes taxes & fees

6 Sept - 7 Sept

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

6. Hampton Inn Poplar Bluff

Poplar Bluff

Philip

S$133

includes taxes & fees

13 Sept - 14 Sept

A Holiday Inn Express & Suites building with a covered entrance, brick facade, and multiple windows.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A lobby with a reception desk, two armchairs, a lamp, and a wall with wood grain artwork.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

7. Holiday Inn Express & Suites Farmington by IHG

Farmington

Shawn

S$152

includes taxes & fees

30 Aug - 31 Aug

A living room with a blue wall, a fireplace, a sofa, and a chair.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A bar area with stools and a counter where a bartender is serving drinks.

8. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

S$130

includes taxes & fees

29 Aug - 30 Aug

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A corner market with a refrigerated display case and a pantry area.

9. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Arsenia

S$145

includes taxes & fees

7 Sept - 8 Sept

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

10. The Riverview

Cape Girardeau

Alyssa

S$153

includes taxes & fees

27 Sept - 28 Sept

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

11. Drury Inn & Suites Sikeston, MO

Sikeston

Sally

S$137

includes taxes & fees

14 Sept - 15 Sept

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

12. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Heather

S$145

includes taxes & fees

17 Sept - 18 Sept

A cabin with a large window, surrounded by trees.

A cabin with a cozy interior, a dining area, and a visible window.

13. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Ronrecus

S$191

includes taxes & fees

31 Aug - 1 Sept

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

14. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Bonnie

S$103

includes taxes & fees

7 Sept - 8 Sept

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

15. Super 8 by Wyndham Farmington

Farmington

Saundra

S$85

includes taxes & fees

3 Sept - 4 Sept

A modern retail area with a display of local items and snacks.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

16. Tru By Hilton Cape Girardeau

Cape Girardeau

Darlene

S$129

includes taxes & fees

3 Sept - 4 Sept

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and a ceiling with recessed lighting.

A modern dining area with high tables and chairs, a television screen, and a view of the outdoors through large windows.

17. Holiday Inn Express & Suites Perryville by IHG

Perryville

Kristen

S$141

includes taxes & fees

3 Sept - 4 Sept

A narrow corridor with a bar area on the right, featuring a counter and hanging lights.

A large boulder in a natural setting with autumn-colored trees in the background.

A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.

18. Black River Motel and Restaurant

Lesterville

Douglas

S$156

includes taxes & fees

7 Sept - 8 Sept

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

19. Crown Pointe Lodge, BW Signature Collection

Farmington

Susan

S$152

includes taxes & fees

6 Sept - 7 Sept

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

20. Perryville RV Resort

Perryville

Von

S$96

includes taxes & fees

30 Aug - 31 Aug

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Holiday Rentals in Southeast Missouri

Cabin

A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A hallway with exposed brick walls, wooden flooring, and a white door.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A cozy living room with wooden ceilings, a ceiling fan, two sofas, a coffee table, a rug, and a bookshelf with books and games.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck and stone steps leading to a porch.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Our one-night stay was very pleasant. The room was comfortable and clean, and it was suitable for my husband, our cat, and me. The staff was friendly and professional. The location was convenient, close to restaurants and the highway. We look forward to staying here again."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Competitively priced. Complimentary happy hour and hot breakfast were exceptional. We stay at a Drury Inn whenever they are available."

Drury Inn & Suites Poplar Bluff

10/10 Excellent

"It feels safe and the staff is amazing! You feel heard and taken care of , great rooms great amenities!"

Honeysuckle Inn - Mountain View

8/10 Good

"There was lots of parking.The breakfast was basic, but appreciated.The staff was the best !! They helped us find places and were very nice 🙂"

Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent

"loved it!!!"

Comfort Inn Festus - St Louis South

8/10 Good

"Staff was very friendly and helpful. Room could have been a little cleaner. Standard free breakfast. Room needed some repairs."

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good

"It was a nice stay"

The Riverview

8/10 Good

"Nice view of the river. The staff was nice."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great value, very clean and breakfast was actually good."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

S$81

13 Sept - 14 Sept

includes taxes & fees

8/10 Very good! (1,001 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

S$90

27 Sept - 28 Sept

includes taxes & fees

7.8/10 Good! (993 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

S$95

30 Aug - 31 Aug

includes taxes & fees

7.2/10 Good! (1,000 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

S$112

29 Aug - 30 Aug

includes taxes & fees

8/10 Very good! (1,000 reviews)

The Farmstead Hotel

778 E 3rd St Caruthersville MO

S$117

29 Aug - 30 Aug

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

S$142

27 Sept - 28 Sept

includes taxes & fees

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia

Car hire Oran

Southeast Missouri Hotels from S$81

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Drury Inn & Suites Jackson MO

2. Fort Davidson Hotel

3. Shepherd Mountain Inn

4. Madison Inn Lodge

5. Drury Plaza Hotel Cape Girardeau Conference Center

6. Hampton Inn Poplar Bluff

7. Holiday Inn Express & Suites Farmington by IHG

8. EC Reed's Mercantile and Hotel

9. Fairfield Inn & Suites by Marriott Poplar Bluff

10. The Riverview

11. Drury Inn & Suites Sikeston, MO

12. Fairfield Inn & Suites by Marriott Cape Girardeau

13. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

14. Pear Tree Inn Cape Girardeau West

15. Super 8 by Wyndham Farmington

16. Tru By Hilton Cape Girardeau

17. Holiday Inn Express & Suites Perryville by IHG

18. Black River Motel and Restaurant

19. Crown Pointe Lodge, BW Signature Collection

20. Perryville RV Resort

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Lake Wappapello

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Tiny Houses of French Village

Urban Lofts

Cozy Belgrade Cottage w/ Wood-burning Stove!

Walk to Current River: Ozarks Adventure Home!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Poplar Bluff

Honeysuckle Inn - Mountain View

Fairfield Inn & Suites by Marriott Poplar Bluff

Comfort Inn Festus - St Louis South

Baymont Inn and Suites by Wyndham Farmington, MO

The Riverview

Drury Inn & Suites Sikeston, MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Comfort Inn Festus - St Louis South

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

The Farmstead Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Southeast Missouri with star rating

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