𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southeast Missouri from S$80 (2026) - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

1. Hampton Inn & Suites By Hilton Festus

Festus

Abram

S$131

includes taxes & fees

29 Oct - 30 Oct

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A building with a red awning labeled "Shepherd Mountain Inn."

2. Shepherd Mountain Inn

Ironton

Michael

S$172

includes taxes & fees

12 Oct - 13 Oct

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

3. Drury Inn & Suites Jackson MO

Jackson

Debra S

S$108

includes taxes & fees

18 Oct - 19 Oct

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

4. Madison Inn Lodge

Fredericktown

Bawan

S$113

includes taxes & fees

3 Nov - 4 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

A brick building with a sign reading "Mercantile & Hotel".

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A bar area with stools and a counter where a bartender is serving drinks.

5. EC Reed's Mercantile and Hotel

Marble Hill

Miranda

S$147

includes taxes & fees

12 Oct - 13 Oct

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

6. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

S$161

includes taxes & fees

18 Oct - 19 Oct

A parking lot with a large building in the background, a truck, and a car.

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

7. Super 8 by Wyndham Farmington

Farmington

Marisa

S$87

includes taxes & fees

23 Oct - 24 Oct

A hotel room with a large bed, a TV, a wooden cabinet, and a painting on the wall.

A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A hotel room with a bed, a sofa, a desk, and a chair.

8. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

S$173

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

9. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

S$147

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

10. Fort Davidson Hotel

Ironton

richard

S$168

includes taxes & fees

10 Nov - 11 Nov

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

11. The Riverview

Cape Girardeau

Alyssa

S$145

includes taxes & fees

13 Oct - 14 Oct

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

12. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

S$130

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

An indoor swimming pool with a clear view of the outside through large windows.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

13. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

S$136

includes taxes & fees

29 Oct - 30 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A gym with cardio equipment, a bench press, and a squat rack.

14. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

stewart

S$80

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

15. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Curtis

S$144

includes taxes & fees

1 Nov - 2 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

16. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

S$140

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A lobby with seating areas, a reception desk, and a bar.

A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

A spacious living room with a sofa set, a coffee table, and a dining area.

17. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kristin

S$182

includes taxes & fees

23 Oct - 24 Oct

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A hotel lobby with a seating area, a reception desk, and a bar.

A swimming pool with a diving board, pool rules signs, and lounge chairs.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

18. Holiday Inn Express & Suites Perryville by IHG

Perryville

Lisa

S$139

includes taxes & fees

8 Nov - 9 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

19. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

S$146

includes taxes & fees

18 Oct - 19 Oct

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

20. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

cynthia

S$205

includes taxes & fees

9 Nov - 10 Nov

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Holiday Rentals in Southeast Missouri

Cabin

A view through a window with a stone wall and a wooden structure in the background.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A hallway with exposed brick walls, wooden flooring, and a white door.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with a wooden ceiling, a fireplace, and a television.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A bedroom with a wooden bed, a bench, and a window.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A covered porch with yellow chairs, a bench, and a small table.

A spacious living area with a kitchen island, dining table, and a television.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A wooden deck with a hot tub, a small table, and a bench.

A bedroom with a sloped ceiling, a bed with a white and yellow bedspread, a wooden chair, a round rug, and a wooden wall with a window.

A rustic wooden interior with a dining table, chairs, a sofa, and a cowhide rug.

A rustic interior with a stone fireplace, wooden furniture, and a cozy seating area.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A red house with a wooden deck and stone steps leading to a porch.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Nice clean large room, basic breakfest, plenty of parking"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Wonderful stay!"

Hampton Inn Sikeston

10/10 Excellent

"The front desk staff were very kind and helpful. Everything was clean and there was a good breakfast!"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Room was clean and staff was very friendly"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

S$80

1 Nov - 2 Nov

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

S$97

1 Nov - 2 Nov

includes taxes & fees

7.2/10 Good! (1,001 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

S$102

24 Oct - 25 Oct

includes taxes & fees

8/10 Very good! (1,000 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

S$104

25 Oct - 26 Oct

includes taxes & fees

9.2/10 Wonderful! (1,001 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

S$107

1 Nov - 2 Nov

includes taxes & fees

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

S$130

18 Oct - 19 Oct

includes taxes & fees

Hotels in Southeast Missouri with star rating

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Car hire Oran

Southeast Missouri Hotels from S$80

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Hampton Inn & Suites By Hilton Festus

2. Shepherd Mountain Inn

3. Drury Inn & Suites Jackson MO

4. Madison Inn Lodge

5. EC Reed's Mercantile and Hotel

6. Crown Pointe Lodge, BW Signature Collection

7. Super 8 by Wyndham Farmington

8. Holiday Inn Express & Suites Farmington by IHG

9. Fairfield Inn & Suites by Marriott Sikeston

10. Fort Davidson Hotel

11. The Riverview

12. Hampton Inn Poplar Bluff

13. Drury Inn & Suites Poplar Bluff

14. Baymont Inn and Suites by Wyndham Farmington, MO

15. Drury Plaza Hotel Cape Girardeau Conference Center

16. Fairfield Inn & Suites by Marriott Poplar Bluff

17. Courtyard by Marriott Cape Girardeau Downtown

18. Holiday Inn Express & Suites Perryville by IHG

19. Fairfield Inn & Suites by Marriott Cape Girardeau

20. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Urban Lofts

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Tiny Houses of French Village

The Atrium - A Boutique Hotel

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Hot Tub & Creek Views: Secluded Perryville Cabin

Cozy Belgrade Cottage w/ Wood-burning Stove!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Cape Girardeau

Hampton Inn Sikeston

Pear Tree Inn Cape Girardeau West

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star rating

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