𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 St. Charles (2026)

An aerial view of a town with industrial buildings, roads, and green areas.

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Our top choices for St. Charles hotels

A two-story house with a porch and a covered entryway.

A room with two patterned sofas, a small table with a lamp, and a window with curtains.

A hallway with a wooden floor, a chandelier, a bust sculpture, and a door leading to another room.

A bedroom with a wooden wardrobe, a bedside table with a lamp, and a bed with white bedding and a red pillow.

1. The Wen Inn formerly Andor Wenneson

Peterson

Naomi

S$157

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern bar area with seating and a counter.

A modern indoor pool area with lounge chairs and a pool.

2. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Lucy

S$174

includes taxes & fees

24 Oct - 25 Oct

A multi-story building with a balcony, surrounded by various potted plants and flowers.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

A bedroom with a four-poster bed, a sofa, a desk, and a fireplace.

3. Green Gables Inn

Lanesboro

Gary

S$116

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A multi-story hotel with a prominent "American" sign, a parking lot with several cars, and a landscaped entrance area.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

4. AmericInn by Wyndham Winona

Winona

Jonathan

S$179

includes taxes & fees

11 Oct - 12 Oct

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A hotel with a covered entrance, multiple floors, and a parking lot.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A small, well-organized pantry with shelves stocked with snacks and beverages.

5. Spark by Hilton Rochester South

Rochester

Stanton

S$124

includes taxes & fees

8 Nov - 9 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A compact laundry area with a washing machine, dryer, and a water fountain.

6. Econo Lodge Mayo Clinic Area

Rochester

Ashley

S$97

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

A cozy living room with a fireplace, a staircase, and a dining area.

7. Stone Mill Hotel & Suites

Lanesboro

Jenifer

S$144

includes taxes & fees

18 Oct - 19 Oct

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

An outdoor dining area with wooden beams, tables, and chairs.

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

8. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

thomas

S$152

includes taxes & fees

7 Nov - 8 Nov

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A laundry area with two Whirlpool washers and a dryer, a wooden shelf above, and a white ceiling.

A reception desk with a wooden finish, a large illuminated 'C' sign, and a modern light fixture on the ceiling.

A modern living room with a sofa, two armchairs, a coffee table, and a large window offering a view of the outdoors.

9. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Phil

S$113

includes taxes & fees

8 Nov - 9 Nov

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

A bar with wooden stools and a neon sign.

10. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Jeanne

S$108

includes taxes & fees

25 Oct - 26 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

A hotel room with a bed, desk, chair, and a bathroom.

A Holiday Inn Express building with a stone facade and illuminated signage.

11. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Melissa

S$133

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

A breakfast area with a coffee station, a refrigerator, and a dining table with chairs.

A gym with treadmills, an elliptical, and a stationary bike.

A reception area with a counter, a clock, a desk with a computer, and a framed picture on the wall.

12. Days Inn by Wyndham Winona

Winona

William

S$94

includes taxes & fees

8 Nov - 9 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern lounge area with seating, a fireplace, and a bar area.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

13. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

S$195

includes taxes & fees

17 Oct - 18 Oct

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

14. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Jon

S$165

includes taxes & fees

17 Oct - 18 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

15. Quality Inn & Suites Mayo Clinic Area

Rochester

Jessica

S$114

includes taxes & fees

1 Nov - 2 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

16. Hampton Inn Rochester-South

Rochester

dennis

S$162

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

17. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Christine

S$168

includes taxes & fees

6 Nov - 7 Nov

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

A hotel reception desk with a modern design, a clock, and a digital screen.

A modern hotel room with a large bed, two bedside tables, and built-in lighting.

A modern lounge area with a curved sofa, a round table, and a seating area with chairs.

18. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park

Jackie

S$145

includes taxes & fees

17 Oct - 18 Oct

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern lounge area with a sofa, chairs, and tables.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern hotel room with a bed, desk, and kitchenette.

19. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

S$187

includes taxes & fees

24 Oct - 25 Oct

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A hotel room with a large round table, two sofas, a TV, and a bed.

A hotel gym with treadmills, elliptical machines, and free weights.

A hotel lobby with a reception desk, seating area, and a large window.

20. Candlewood Suites Rochester Mayo Clinic Area by IHG

Rochester

Kevin

S$171

includes taxes & fees

17 Oct - 18 Oct

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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

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Top St. Charles Hotel Reviews

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Only thing was the pool door was locked."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Great hotel and very clean!"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"N/A"

Kahler Grand Hotel

10/10 Excellent

"Good"

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"It was a fine hotel that was very busy."

The Berkman

10/10 Excellent

"Room was awesome! We had the 3 bedroom unit, which had a large and spacious balcony. Plenty of sunlight came through those windows. We couldn’t had had a better room!"

Hampton Inn Rochester-South

8/10 Good

"The room we originally got had a malfunctioning AC unit so they moved us to another room, which we appreciated. However, the building must be older as we clearly heard people walking in the room above us. and the design of the bathroom door meant it hit the room door if it were in a particular position. Also, the water in the bathroom came out slowly. Breakfast was good, and so was the soup supper offered Sunday thru Thursday."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Great location. Great accommodations. Highly recommended."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"The room was very clean. Staff were kind and pleasant upon check in."

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

S$80

8 Nov - 9 Nov

includes taxes & fees

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

S$86

18 Oct - 19 Oct

includes taxes & fees

7.6/10 Good! (90 reviews)

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

S$111

11 Oct - 12 Oct

includes taxes & fees

7.8/10 Good! (1,030 reviews)

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN

S$113

8 Nov - 9 Nov

includes taxes & fees

8.8/10 Excellent! (1,000 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

S$133

8 Nov - 9 Nov

includes taxes & fees

8.8/10 Excellent! (1,002 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

S$184

29 Oct - 30 Oct

includes taxes & fees

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

St. Charles Hotels from S$80

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. The Wen Inn formerly Andor Wenneson

2. Hyatt House Rochester/Mayo Clinic Area

3. Green Gables Inn

4. AmericInn by Wyndham Winona

5. Spark by Hilton Rochester South

6. Econo Lodge Mayo Clinic Area

7. Stone Mill Hotel & Suites

8. Hotel Indigo Rochester – Mayo Clinic Area by IHG

9. Comfort Inn & Suites Rochester South Mayo Clinic

10. AmericInn by Wyndham Rochester Near Mayo Clinic

11. Holiday Inn Express Rochester South - Mayo Area by IHG

12. Days Inn by Wyndham Winona

13. Residence Inn by Marriott Rochester Mayo Clinic Area South

14. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

15. Quality Inn & Suites Mayo Clinic Area

16. Hampton Inn Rochester-South

17. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

18. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

19. Home2 Suites by Hilton Rochester Mayo Clinic Area

20. Candlewood Suites Rochester Mayo Clinic Area by IHG

Learn more about St. Charles

Top St. Charles Hotel Reviews

Med City Inn & Suites - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Kahler Grand Hotel

Kahler Inn and Suites - Mayo Clinic Area

The Berkman

Hampton Inn Rochester-South

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hyatt House Rochester/Mayo Clinic Area

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Birch Hill Suite Rochester – Med City

Med City Inn & Suites - Mayo Clinic Area

Comfort Inn & Suites Rochester South Mayo Clinic

Holiday Inn Express Rochester South - Mayo Area by IHG

Brentwood Inn & Suites

Frequently asked questions

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