Medical Center District Holidays

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    Save up to S$1,300 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Price found within the past 48 hours. Click for updated prices.
Red Roof Inn San Antonio - Airport

Red Roof Inn San Antonio - Airport

2 out of 5
Uptown Central
Price was S$765, price is now S$727 per person
S$727
per person
7 Dec - 14 Dec
found 7 hours ago
Return flight included
Los Angeles (LAX) to San Antonio (SAT)
8.2/10 Very good! (1,488 reviews)

Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport

3 out of 5
Uptown Central
Price was S$1,075, price is now S$905 per person
S$905
per person
7 Dec - 14 Dec
found 7 hours ago
Return flight included
Los Angeles (LAX) to San Antonio (SAT)
8.6/10 Excellent! (2,005 reviews)

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

2.5 out of 5
Uptown Central
Price was S$1,005, price is now S$856 per person
S$856
per person
7 Dec - 14 Dec
found 7 hours ago
Return flight included
Los Angeles (LAX) to San Antonio (SAT)
9/10 Wonderful! (2,322 reviews)
While the overworked staff was excellent, the air conditioning and heat was a problem we were cold to freezing most night had to get two blankets for each bed and observed other occupants varying extra blankets also. Breakfast was dismal, what’s with the fake eggs. Let’s not talk about the bathroom and the sink outside the bathroom

Reviewed on 3 Nov, 2026

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

4 out of top 10 points of interest in this area

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is S$135 per night from 4 Nov to 5 Nov
S$135
4 Nov - 5 Nov
includes taxes & fees
8.4/10 Very good! (3,766 reviews)
"The price was great but that is all that was good. The floors were filthy in our room. The shower head did not work. Our room was not cleaned for our 2nd day there. When we asked about it, we were told that the cleaning people only come every 3 days!!! We had to take our dirty towels to get clean ..."

Reviewed on 3 Nov, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is S$143 per night from 3 Dec to 4 Dec
S$143
3 Dec - 4 Dec
includes taxes & fees
San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is S$137 per night from 12 Nov to 13 Nov
S$137
12 Nov - 13 Nov
includes taxes & fees
Drury Inn & Suites San Antonio Northwest Medical Center
See all 4,933 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Medical Centre District holiday package cost?
Starting from just S$727, a holiday package is your passport to low-priced travel. Create your own Medical Centre District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Centre District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Centre District holiday package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your holiday your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfil those holiday dreams.
Where should I stay in Medical Centre District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Centre District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Centre are two of the most well-known hotels in Medical Centre District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Centre District holiday?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Centre District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Centre District holiday.
What should I know before booking a Medical Centre District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Centre District Expedia holiday package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Centre District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Centre District holiday package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Centre District holiday package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Stay near popular Medical Center District attractions

Cinemark San Antonio 16

You can take time to visit Cinemark San Antonio 16 during your travels to San Antonio.
See properties

Things to do

San Antonio Zoo Any Day Ticket including ZooLights

San Antonio Zoo Any Day Ticket

S$38
per adult
96% of travellers recommend
San Antonio Zoo Any Day Ticket
SEA LIFE San Antonio

SEA LIFE San Antonio

S$33
per adult
76% of travellers recommend
SEA LIFE San Antonio
San Antonio CityPASS®

San Antonio CityPASS®: Save on admission to 4 must-see attractions

S$80
per adult
96% of travellers recommend
San Antonio CityPASS®: Save on admission to 4 must-see attractions
See all activities in San Antonio

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.