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Hotels in Otay Mesa

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Check prices for these dates

This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,856 reviews)
"Clean room and the staff very nice"
United States
Veronica
The price is S$201
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,005 reviews)
"Very quiet and friendly staff excellent breakfast"
United States
Mia
The price is S$154
includes taxes & fees
13 Sept - 14 Sept
Quality Suites San Diego Otay Mesa
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

3. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,368 reviews)
"Great stay"
United States
Luis
The price is S$164
includes taxes & fees
20 Sept - 21 Sept
Best Western Americana Inn
An outdoor patio area with seating and a bar.

4. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,071 reviews)
"We love this hotel: all the staff are very nice and helpful."
United States
Shan Shan
The price is S$245
includes taxes & fees
20 Sept - 21 Sept
Ayres Hotel San Diego South - Chula Vista
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

5. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,728 reviews)
"Great amenities, clean rooms, staff is extremely helpful."
United States
Sharon
The price is S$149
includes taxes & fees
13 Sept - 14 Sept
La Quinta Inn by Wyndham San Diego Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

6. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,649 reviews)
"Great hotel to stay."
United States
Katsuya
The price is S$146
includes taxes & fees
4 Oct - 5 Oct
Comfort Inn Chula Vista San Diego South
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

7. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,501 reviews)
"Enjoyed my stay"
United States
Cathie
The price is S$209
includes taxes & fees
21 Sept - 22 Sept
Holiday Inn Express San Diego South - Chula Vista by IHG
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

8. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,073 reviews)
"Great stay!"
United States
Samuel
The price is S$209
includes taxes & fees
7 Sept - 8 Sept
Best Western Plus Marina Gateway Hotel

9. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (759 reviews)
"Nice hotel"
United States
Alfonso
The price is S$276
includes taxes & fees
27 Sept - 28 Sept
SpringHill Suites by Marriott Chula Vista Eastlake
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

10. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,505 reviews)
"The room was clean, and the staff was very helpful"
United States
Mahmoud
The price is S$139
includes taxes & fees
20 Sept - 21 Sept
Hercor Hotel - Urban Boutique
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

11. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,201 reviews)
"Just a great place to stay!"
United States
Tracy
The price is S$190
includes taxes & fees
8 Sept - 9 Sept
The Rambler Hotel
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

12. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.4 out of 10, Good, (2,305 reviews)
"Great place to stay and very convenient"
United Kingdom
Idanesha
The price is S$99
includes taxes & fees
4 Oct - 5 Oct
Hotel Palmeras Chula Vista
A hotel room with two beds, a desk, and a chair.

13. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,123 reviews)
"Great hotel"
United States
Erika
The price is S$107
includes taxes & fees
4 Oct - 5 Oct
Howard Johnson by Wyndham National City/San Diego South
A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.

14. Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,426 reviews)
"Great stay"
United States
Bernadette
The price is S$189
includes taxes & fees
28 Sept - 29 Sept
Lamplighter Inn & Suites at SDSU
A hotel with a large pool area, multiple lounge chairs, and umbrellas.

15. Sun Outdoors San Diego Bay

Sun Outdoors San Diego Bay
2.0 star property
15 km from Otay Mesa
10.0 out of 10, Exceptional, (107 reviews)
"This property exceeded our expectations, we will definitely return!"
United States
julie
The price is S$359
includes taxes & fees
1 Oct - 2 Oct
Sun Outdoors San Diego Bay
A balcony with wicker furniture overlooking a marina and a coastal cityscape.

16. Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.6 out of 10, Excellent, (3,670 reviews)
"Lovely resort with great food and great location . Good for a relaxing getaway ."
United States
Pooja
The price is S$286
includes taxes & fees
7 Sept - 8 Sept
Sheraton San Diego Resort
A Holiday Inn Express hotel with a clear entrance, a parking lot, and a landscaped area with plants.

17. Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,092 reviews)
"Very good hotel at the price with good choice of breakfast."
United States
Tirthankar
The price is S$206
includes taxes & fees
23 Sept - 24 Sept
Holiday Inn Express San Diego Airport - Old Town by IHG
A multi-story hotel with a prominent entrance, a stone facade, and a clear sky.

18. WoodSpring Suites Santee - San Diego Northeast

WoodSpring Suites Santee - San Diego Northeast
2.5 star property
30.9 km from Otay Mesa
8.6 out of 10, Excellent, (237 reviews)
"Great place to stay"
United States
Adan
The price is S$138
includes taxes & fees
6 Sept - 7 Sept
WoodSpring Suites Santee - San Diego Northeast
A swimming pool with palm trees and a mountain in the background.

19. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,140 reviews)
"The golf courses and hotel were great!"
United States
Tom
The price is S$168
includes taxes & fees
9 Sept - 10 Sept
Sycuan Casino Resort
An outdoor dining area with a long table and chairs, a street view, and a building with a 'P' parking sign.

20. Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1,392 reviews)
"Great room, location and price"
United States
Linda
The price is S$191
includes taxes & fees
7 Sept - 8 Sept
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A beach with surfers and swimmers during sunset.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

10/10 Excellent
"Great experience!"
Arturo M 4-night trip
Posted 2 hours ago
Hard Rock Hotel San Diego

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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