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Find Luxury Hotels in Southeast Missouri

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Check availability on Southeast Missouri Luxury Hotels

Tonight
22 Oct - 23 Oct
Tomorrow
23 Oct - 24 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Southeast Missouri luxury hotels

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

1. The Riverview

The Riverview
Cape Girardeau
S$150
includes taxes & fees
18 Nov - 19 Nov
The Riverview
An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.
A restaurant with round tables and chairs, a bar area, and a patterned ceiling.
A spa bath with a sign indicating a capacity of 8 persons.
A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.

2. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
S$194
includes taxes & fees
1 Nov - 2 Nov
Drury Plaza Hotel St. Louis Brentwood
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Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Super clean and helpful friendly staff. Rooms are a bit small but still nice and modern. Only downside was no breakfast."
Sarah 1-night trip
Posted 1 day ago
Motel 6 Poplar Bluff, MO

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