S$252 Cheap Flights from Panama City to Medellín

View S$252 flight on Thu, 6 Nov, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)

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Cheap Flights from Panama City to Medellín (PTY-MDE)

Prices were available within the past 7 days and start at S$252 for one-way flights and S$479 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$479 Return, found 19 hours ago
S$479
Return
found 19 hours ago
Select Copa flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$479 found 19 hours ago
avianca
Thu, 12 Mar - Mon, 16 Mar
PTY
Panama City
MDE
Medellin
S$482 Return, found 4 days ago
S$482
Return
found 4 days ago
Select avianca flight, departing Thu, 12 Mar from Panama City to Medellin, returning Mon, 16 Mar, priced at S$482 found 4 days ago
avianca
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$483 Return, found 19 hours ago
S$483
Return
found 19 hours ago
Select avianca flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$483 found 19 hours ago
Copa
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$502 Return, found 19 hours ago
S$502
Return
found 19 hours ago
Select Copa flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$502 found 19 hours ago
Copa
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$514 Return, found 19 hours ago
S$514
Return
found 19 hours ago
Select Copa flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$514 found 19 hours ago
avianca
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$525 Return, found 19 hours ago
S$525
Return
found 19 hours ago
Select avianca flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$525 found 19 hours ago
Copa
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$541 Return, found 19 hours ago
S$541
Return
found 19 hours ago
Select Copa flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$541 found 19 hours ago
avianca
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$543 Return, found 19 hours ago
S$543
Return
found 19 hours ago
Select avianca flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$543 found 19 hours ago
Copa
Thu, 12 Mar - Mon, 16 Mar
PTY
Panama City
MDE
Medellin
S$549 Return, found 4 days ago
S$549
Return
found 4 days ago
Select Copa flight, departing Thu, 12 Mar from Panama City to Medellin, returning Mon, 16 Mar, priced at S$549 found 4 days ago
avianca
Thu, 12 Mar - Mon, 16 Mar
PTY
Panama City
MDE
Medellin
S$559 Return, found 4 days ago
S$559
Return
found 4 days ago
Select avianca flight, departing Thu, 12 Mar from Panama City to Medellin, returning Mon, 16 Mar, priced at S$559 found 4 days ago
Copa
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$562 Return, found 19 hours ago
S$562
Return
found 19 hours ago
Select Copa flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$562 found 19 hours ago
Copa
Thu, 12 Mar - Mon, 16 Mar
PTY
Panama City
MDE
Medellin
S$575 Return, found 4 days ago
S$575
Return
found 4 days ago
Select Copa flight, departing Thu, 12 Mar from Panama City to Medellin, returning Mon, 16 Mar, priced at S$575 found 4 days ago
Copa
Thu, 6 Nov - Thu, 13 Nov
PTY
Panama City
MDE
Medellin
S$576 Return, found 19 hours ago
S$576
Return
found 19 hours ago
Select Copa flight, departing Thu, 6 Nov from Panama City to Medellin, returning Thu, 13 Nov, priced at S$576 found 19 hours ago
Aeromexico
Thu, 12 Mar - Mon, 16 Mar
PTY
Panama City
MDE
Medellin
S$916 Return, found 4 days ago
S$916
Return
found 4 days ago
Select Aeromexico flight, departing Thu, 12 Mar from Panama City to Medellin, returning Mon, 16 Mar, priced at S$916 found 4 days ago

Find the cheapest month to fly from Panama City (PTY) to Medellín (MDE)

January is typically the cheapest month to fly

From S$237 - S$464 per traveller.

Graph displaying average flight prices per month

Panama City to Medellín route information
Origin airport
Tocumen Intl.
Destination airport
José María Córdova Intl.
Airlines serving
Copa, avianca
Return price
S$479
Distance
539 km
Average flight time
1 hour 21 mins

Perfect flights from Panama City to Medellín

Your Journey from Panama City to Medellín

Start your unforgettable journey with Expedia. Our broad selection of flights from Panama City to Medellín caters to every travel need. Whether you're yearning for a romantic escape, a solo adventure, or a cultural immersion, we've got you covered.
 

Choosing Your Ideal Flight

With Expedia, you have access to a wide range of airlines, including Copa, avianca, Aeromexico. Our selection of flights from Tocumen Intl. to José María Córdova Intl. caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from 20 airlines, you're bound to find the perfect flight.
 

Maximizing Value with Panama City to Medellín Flights

Experience the joy of finding cheap flights from Tocumen Intl. to José María Córdova Intl. that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares from S$252 and roundtrip prices from S$479*.
 

Pre-Flight Essentials

Ensure a smooth journey from Panama City to Medellín with Expedia. From information about check-in times and in-flight amenities to guidance on baggage policies, we provide all the essentials to prepare you for your flight.
 

Experience the Vibrant Medellín

Picture yourself stepping off the plane in Medellín and immersing yourself in the unique atmosphere of Rionegro. From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
 

Added Convenience on Your Panama City to Medellín Flight

Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Panama City to Medellín.
 

Beyond the Flight – Exploring Medellín

With Expedia, your adventure extends beyond the flight. Explore Medellín at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
 

Book Your Flight from Panama City to Medellín with Confidence

Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Panama City to Medellín with confidence. Book your travel arrangements with Expedia today.
 
*Note: Prices may vary based on availability and are subject to change.

Frequently asked questions

How much is a flight from PTY to Medellin Airport?
Within the past 7 days on Expedia, for flights departing within the next year, the lowest price available for a round-trip journey from PTY to Medellin Airport was S$479. Cheap tickets don't wait forever, so book yours today. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Tocumen Intl. Airport (PTY) to Medellin Airport?
We understand that things crop up unexpectedly, so we've made it as simple as possible for you to cancel your trip online. Just visit the Customer Service Portal and follow the instructions.
How do I find cheap flights from Panama Airport to Jose Maria Cordova Intl. Airport (MDE) that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for PTY to MDE flights, you'll see a "no change fees" filter for you to select.
How far is the flight from PTY to MDE?
A flight distance of just 540 kilometres separates Tocumen and Rionegro. Once you're up in the air, you won't have time to do much more than listen to some short podcasts.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to MDE?
Copa Airlines (CM) is one of the top choices for travellers jetting between PTY and Medellin Airport. Select from the 199 flights it offers on this route each month. You could also have a look at fares with Copa Airlines Colombia (P5). This carrier operates 13 flights a month between Tocumen and Rionegro.
Are PTY to MDE flight tickets cheaper when they're purchased at the last minute?
It is possible to nab great last-minute deals from PTY to Medellin Airport, but it's also possible to miss out entirely! As many airlines release seats up to 12 months in advance, it's worthwhile keeping an eye on fares early and being ready to book when you see a bargain. Expedia compares carrier prices and updates flight deals regularly, so you can feel confident knowing you're always getting the latest offers.

Explore a world of travel with Expedia

*Available to Expedia members.