Hotels in Otay Mesa
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Otay Mesa hotels
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.0 out of 10, Good, (1,000 reviews)
"Clean, convenient location "
Mary
The price is S$145
includes taxes & fees
17 Jan - 18 Jan
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1,589 reviews)
"Great place to stay. Really clean and helpful staff "
Zulma
The price is S$174
includes taxes & fees
25 Jan - 26 Jan
Berkshire Motor Hotel
Berkshire Motor HotelNorth Park, 26.7 km from Otay Mesa
8.4 out of 10, Very good, (1,002 reviews)
"Clean, very chill easy check in"
Susana
The price is S$119
includes taxes & fees
25 Jan - 26 Jan
Westgate Hotel
Westgate Hotel24.9 km from Otay Mesa
9.0 out of 10, Wonderful, (1,003 reviews)
"The hotel was a great stay. Beautiful lobby, large room and such a comfortable bed."
Victor
Sea Harbor Hotel
Sea Harbor Hotel30.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,002 reviews)
"Room was spotless, great location."
Dennis
Courtyard by Marriott Old Town
Courtyard by Marriott Old TownOld Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1,003 reviews)
"Wonderful location and staff is outstanding!!"
Kathleen
The price is S$200
includes taxes & fees
22 Jan - 23 Jan
Springhill Suites San Diego Mission Valley
Springhill Suites San Diego Mission Valley28.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,001 reviews)
"Very friendly staff, quick check-in, spacious room, and very clean! Great place to stay! "
Jodi
The price is S$235
includes taxes & fees
19 Jan - 20 Jan
Ocean Villa Inn
Ocean Villa InnOcean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,149 reviews)
"It’s good place for the value "
Marcin
Heritage Inn San Diego
Heritage Inn San Diego31.8 km from Otay Mesa
7.4 out of 10, Good, (1,209 reviews)
"The room was nice"
Charlotte
The price is S$99
includes taxes & fees
18 Jan - 19 Jan
Best Western Plus Bayside Inn
Best Western Plus Bayside Inn25.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,003 reviews)
"Excellent hotel with outstanding comfort and service. The room was extremely comfortable, clean, and modern. The bed was perfect, and the room was very quiet, which allowed us to sleep very well.
This hotel exceeded our expectations. Highly recommended, and we will definitely stay here again"
Nara
The price is S$194
includes taxes & fees
25 Jan - 26 Jan
La Pensione Hotel
La Pensione HotelLittle Italy, 25.8 km from Otay Mesa
8.6 out of 10, Excellent, (1,892 reviews)
"Great location "
Jingying
Old Town Western Inn & Suites
Old Town Western Inn & SuitesOld Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1,004 reviews)
"Clean, good staff, quiet, good location "
Raul
Staypineapple, Hotel Z, Gaslamp San Diego
Staypineapple, Hotel Z, Gaslamp San DiegoGaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1,006 reviews)
"Outstanding hotel"
Lee
The price is S$164
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn & Suites by Hilton San Diego SeaWorld
Hampton Inn & Suites by Hilton San Diego SeaWorld30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (526 reviews)
"Excellent hotel!"
Jorge
The price is S$162
includes taxes & fees
25 Jan - 26 Jan
Ocean Beach Hotel
Ocean Beach HotelOcean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,276 reviews)
"Great location."
Maryna
Hilton Garden Inn San Diego Downtown/Bayside
Hilton Garden Inn San Diego Downtown/Bayside26.2 km from Otay Mesa
8.6 out of 10, Excellent, (1,236 reviews)
"Very clean and a smooth valet, check in/out process. Rooms very spacious and located by little Italy/embarcadero. Lovely locations to explore "
savannah
The price is S$206
includes taxes & fees
20 Jan - 21 Jan
The Beau Downtown San Diego Gaslamp Quar
The Beau Downtown San Diego Gaslamp QuarGaslamp Quarter, 24.5 km from Otay Mesa
8.8 out of 10, Excellent, (576 reviews)
"A very nice spot to stay in the gas lamp district. "
Janet
The price is S$173
includes taxes & fees
21 Jan - 22 Jan
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Hilton Garden Inn San Diego Old Town/SeaWorld AreaOld Town San Diego, 30.5 km from Otay Mesa
8.6 out of 10, Excellent, (1,320 reviews)
"Great location! "
Juan
The price is S$205
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,710 reviews)
"Great place to stay for access to the airport, staff was super!"
Alison
The price is S$250
includes taxes & fees
24 Jan - 25 Jan
Best Western Yacht Harbor Hotel
Best Western Yacht Harbor Hotel29.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,677 reviews)
"Spotless room, nice staff, great breakfast"
DAVID
The price is S$166
includes taxes & fees
19 Jan - 20 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Frequently asked questions
Explore a world of travel with Expedia
- 4 Star Hotels in Otay Ranch Village 1
- Hotels near B Street Cruise Ship Terminal
- Barrio Logan Hotels
- Bonita Hotels
- Castle Park Hotels
- Cabin Rentals in Chula Vista
- Hotels with smoking rooms in Chula Vista
- Chula Vista Hotels
- Hotels near Coronado Ferry Landing
- Coronado Hotels
- Downtown San Diego Hotels
- Dulzura Hotels
- El Cajon Hotels
- Gaslamp Quarter Hotels
- Golden Hill Hotels
- Condo Rentals in Imperial Beach
- Hotels with Spa in Imperial Beach
- Imperial Beach Hotels
- Hotels near Kaiser Permanente Otay Mesa Medical Offices
- La Presa Hotels
- Hotels near Las Americas Premium Outlets
- Lemon Grove Hotels
- National City Hotels
- North Park Hotels
- Otay Mesa West Hotels
- Hotels near Petco Park
- Condo Rentals in San Diego Coast
- Adults Only Hotels in San Diego Coast
- Scuba Diving Hotels in San Diego Coast
- Villas in San Diego Coast
- Hotels near San Diego Convention Center
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- Family friendly Hotels in San Ysidro
- San Ysidro Hotels
- Hotels near Seaport Village
- Hotels near Sharp Chula Vista Medical Center
- Sherman Heights Hotels
- All Inclusive Hotels and Resorts in South Bay
- Villas in South Bay
- Hotels with Airport Shuttle in South San Diego
- Spring Valley Hotels
- Flights to Chula Vista
- Flights to Imperial Beach
- Flights to Spring Valley
- Flights from Brown Field Municipal
- Flights from Imperial Beach
- Flights from Bonita
- Flights from Lemon Grove
- Flights from South Bay
- Flights from Chula Vista
- Flights from Amsterdam (AMS) to San Diego (SDM)
- Flights from Atlanta (ATL) to San Diego (SDM)
- Flights from Hartford (BDL) to San Diego (SDM)
- Flights from León (BJX) to San Diego (SDM)
- Flights from Bangkok (BKK) to San Diego (SDM)
- Flights from Beaumont (BMT) to San Diego (SDM)
- Flights from Baltimore (BWI) to San Diego (SDM)
- Flights from Upland (CCB) to San Diego (SDM)
- Flights from Calipatria (CLR) to San Diego (SDM)
- Flights from Compton (CPM) to San Diego (SDM)
- Flights from Ensenada (ESE) to San Diego (SDM)
- Flights from Fresno (FAT) to San Diego (SDM)
- Flights from Sioux Falls (FSD) to San Diego (SDM)
- Flights from Honolulu (HNL) to San Diego (SDM)
- Flights from Jacksonville (JAX) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Mexico City (MEX) to San Diego (SDM)
- Flights from Miami (MIA) to San Diego (SDM)
- Flights from Norfolk (ORF) to San Diego (SDM)
- Flights from Phoenix (PHX) to San Diego (SDM)
- Flights from Fort Myers (RSW) to San Diego (SDM)
- Flights from Saint-Denis (RUN) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Singapore (SIN) to San Diego (SAN)
- Flights from Tijuana (TIJ) to San Diego (SDM)
- Flights from Tampa (TPA) to San Diego (SDM)
- Flights from Van Nuys (VNY) to San Diego (SDM)
- Flights from Vancouver (YVR) to San Diego (SDM)