Default HTG hotel image

Hotels in Otay Mesa West

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
11 Sept - 13 Sept
In two weeks
18 Sept - 20 Sept

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Otay Mesa West hotels

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

1. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
2.1 km from Otay Mesa West
8.8 out of 10, Excellent, (1,368 reviews)
"Great stay"
United States
Luis
The price is S$164
includes taxes & fees
4 Oct - 5 Oct
Best Western Americana Inn
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

2. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
7.8 km from Otay Mesa West
8.6 out of 10, Excellent, (1,729 reviews)
"Great amenities, clean rooms, staff is extremely helpful."
United States
Sharon
The price is S$147
includes taxes & fees
20 Sept - 21 Sept
La Quinta Inn by Wyndham San Diego Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

3. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
7.9 km from Otay Mesa West
8.2 out of 10, Very good, (1,652 reviews)
"Great hotel to stay."
United States
Katsuya
The price is S$153
includes taxes & fees
4 Oct - 5 Oct
Comfort Inn Chula Vista San Diego South
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

4. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1,503 reviews)
"Enjoyed my stay"
United States
Cathie
The price is S$200
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express San Diego South - Chula Vista by IHG
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

5. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
10.5 km from Otay Mesa West
9.2 out of 10, Wonderful, (4,086 reviews)
"Great stay!"
United States
Samuel
The price is S$208
includes taxes & fees
8 Sept - 9 Sept
Best Western Plus Marina Gateway Hotel
An outdoor patio area with seating and a bar.

6. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.2 km from Otay Mesa West
9.8 out of 10, Exceptional, (1,073 reviews)
"We love this hotel: all the staff are very nice and helpful."
United States
Shan Shan
The price is S$271
includes taxes & fees
7 Sept - 8 Sept
Ayres Hotel San Diego South - Chula Vista
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

7. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
6.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,505 reviews)
"The room was clean, and the staff was very helpful"
United States
Mahmoud
The price is S$138
includes taxes & fees
21 Sept - 22 Sept
Hercor Hotel - Urban Boutique
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

The Rambler Hotel
3.0 star property
8 km from Otay Mesa West
9.0 out of 10, Wonderful, (2,206 reviews)
"Just a great place to stay!"
United States
Tracy
The price is S$162
includes taxes & fees
6 Oct - 7 Oct
The Rambler Hotel
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

9. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
7.8 km from Otay Mesa West
7.4 out of 10, Good, (2,305 reviews)
"Great place to stay and very convenient"
United Kingdom
Idanesha
The price is S$95
includes taxes & fees
9 Sept - 10 Sept
Hotel Palmeras Chula Vista

10. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
12.4 km from Otay Mesa West
9.6 out of 10, Exceptional, (763 reviews)
"Nice hotel"
United States
Alfonso
The price is S$275
includes taxes & fees
27 Sept - 28 Sept
SpringHill Suites by Marriott Chula Vista Eastlake
An outdoor dining area with a long table and chairs, a street view, and a building with a 'P' parking sign.

11. Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,395 reviews)
"Staff was super friendly upon arrival. Our room was clean and location was great!"
United States
RheaAnn
The price is S$190
includes taxes & fees
7 Sept - 8 Sept
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
A balcony with wicker furniture overlooking a marina and a coastal cityscape.

12. Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
21.4 km from Otay Mesa West
8.6 out of 10, Excellent, (3,676 reviews)
"Lovely resort with great food and great location . Good for a relaxing getaway ."
United States
Pooja
The price is S$310
includes taxes & fees
7 Sept - 8 Sept
Sheraton San Diego Resort
A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.

13. Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
21 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,427 reviews)
"Great stay"
United States
Bernadette
The price is S$189
includes taxes & fees
28 Sept - 29 Sept
Lamplighter Inn & Suites at SDSU
A modern hotel room with a large bed, bedside tables, a desk, and a wardrobe.

14. Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
22.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,094 reviews)
"Very good hotel at the price with good choice of breakfast."
United States
Tirthankar
The price is S$226
includes taxes & fees
21 Sept - 22 Sept
Holiday Inn Express San Diego Airport - Old Town by IHG
A hotel courtyard with outdoor seating, palm trees, and a view of the sea.

15. Courtyard by Marriott San Diego Airport/Liberty Station

Courtyard by Marriott San Diego Airport/Liberty Station
3.0 star property
22.8 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,269 reviews)
"Staff was extremely helpful, bar was wonderful, and breakfasts were very enjoyable."
United States
Marianne
The price is S$284
includes taxes & fees
4 Oct - 5 Oct
Courtyard by Marriott San Diego Airport/Liberty Station

16. Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 17.5 km from Otay Mesa West
9.0 out of 10, Wonderful, (4,300 reviews)
"Really nice place to stay, I would stay there again if I have the opportunity"
United States
Carlos
The price is S$312
includes taxes & fees
28 Sept - 29 Sept
Hard Rock Hotel San Diego
A hotel room with two beds, a desk, a chair, and a view of the cityscape.

17. Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 18.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (2,838 reviews)
"Awesome stay!"
United States
Steven
The price is S$361
includes taxes & fees
7 Sept - 8 Sept
Manchester Grand Hyatt San Diego
An outdoor patio area with tables and chairs, string lights, and a building with balconies.

18. Fairfield Inn & Suites San Diego Old Town

Fairfield Inn & Suites San Diego Old Town
3.0 star property
Old Town San Diego, 23.1 km from Otay Mesa West
8.8 out of 10, Excellent, (1,171 reviews)
"Great being near Old Town nice food nearby and fun visitor destinations."
United States
Anthony
The price is S$184
includes taxes & fees
7 Sept - 8 Sept
Fairfield Inn & Suites San Diego Old Town
A modern bar area with a curved counter, multiple bar stools, and a large window offering a view of the cityscape.

19. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Gaslamp Quarter, 17.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (2,368 reviews)
"Overall stay was great. Staff was nice and hotel is in a great location"
United States
katrice
The price is S$303
includes taxes & fees
7 Sept - 8 Sept
Omni San Diego Hotel at the Ballpark
A two-story house with a covered porch, a garden with various flowers, and an American flag.

20. Cherokee Lodge

Cherokee Lodge
2.5 star property
17 km from Otay Mesa West
9.4 out of 10, Exceptional, (900 reviews)
"Lovely room, very quiet, clean, close to restaurants, walking, sightseeing, the ocean. Recommend!"
United States
Martha
The price is S$277
includes taxes & fees
17 Sept - 18 Sept
Cherokee Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A beach with surfers and swimmers during sunset.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa West Hotel Reviews

Paradise Point Resort & Spa

Paradise Point Resort & Spa

10/10 Excellent
"Beautiful resort and really lovely staff! We had a fantastic visit. (Only downside: The air conditioning unit was noisy and way under par considering how great the room was in every other way.)"
Anne-Marie 5-night trip
Posted 3 hours ago
Paradise Point Resort & Spa

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.

Explore a world of travel with Expedia