Name: Megapolis Hotel Panamá
Price range: S$226

Stay near popular Santa Ana attractions

El Machetazo Santa Ana

You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.

See properties

Things to do

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

S$126

per adult

94% of travellers recommend

Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

S$61

per adult

98% of travellers recommend

Panama: Monkey and Sloth Jungle Habitat Panama Tour

S$77

per adult

100% of travellers recommend

Panama City Visit an Indian town Embera and waterfall with lunch

S$53

per adult

96% of travellers recommend

From Panama City: San Blas Island Hopping Day Tour

S$185

per adult

98% of travellers recommend

Half day of Panama city and canal tour: shared and private

S$85

per adult

96% of travellers recommend

See all activities in Panama City

Top hotels in Santa Ana

Hotel Caracas - Casco Viejo

Plaza De Santa Ana Panama City Provincia di Panama

S$55

8 Oct - 9 Oct

includes taxes & fees

Stay at this hotel in Panama City. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera ...

8/10 Very good! (19 reviews)

"Good location but basic otherwise. Staff not overly helpful on the whole."

Reviewed on 27 Sept, 2026

Casco View Apartments

C. 16 Oeste Panama City Provincia de Panamá

S$149

1 Oct - 2 Oct

includes taxes & fees

Stay at this business-friendly condo in Panama City. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...

9/10 Wonderful! (106 reviews)

"We really enjoyed our stay at Casco View. It was an easy walk into Casca Viejo and centrally located. The host uses a guesty app to provide room details, apartment codes, etc, so it was a really easy and smooth process to get checked in. The room itself was very clean and well appointed. We stayed ..."

Reviewed on 8 Sept, 2026

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

S$193

27 Oct - 28 Oct

includes taxes & fees

Stay at this luxury hotel in Panama City. Enjoy free breakfast, free Wi-Fi and 3 restaurants. Our guests praise the breakfast and the pool in their reviews. ...

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

S$197

30 Oct - 31 Oct

includes taxes & fees

Stay at this family-friendly hotel in Tocumen. Enjoy free Wi-Fi, breakfast (surcharge) and a free airport shuttle. Our guests praise the breakfast and the pool ...

8.6/10 Excellent! (2,752 reviews)

"Super convenient location"

Reviewed on 30 Sept, 2026

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama

S$267

2 Oct - 3 Oct

includes taxes & fees

Stay at this spa hotel in Panama City. Enjoy free Wi-Fi, a full-service spa and 3 restaurants. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,000 reviews)

"Beautiful hotel, amazing food, and even better staff. Everyone went above and beyond to genuinely make us feel welcome, and you could tell they took a lot of pride in the hotel and their roles. A special thank you to Jose Luis, Victor, Felix, and the rest of the restaurant staff. They were excellent ..."

Reviewed on 29 Sept, 2026

Megapolis Hotel Panamá

Avenida Balboa Panama City

S$226

26 Oct - 27 Oct

includes taxes & fees

Stay at this luxury hotel in Panama City. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their reviews. ...

See all 1,792 properties in Santa Ana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A harbor with several boats docked in the foreground and a city skyline in the background.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.