There are several airlines that operate frequent flights from Zurich (ZRH) to San Francisco (SFO) including

• Swiss International Air Lines with 156 flights a week
• United Airlines with 99 flights a week
• Lufthansa Cargo with 50 flights a week
• Delta Air Lines with 36 flights a week
• American Airlines with 18 flights a week

The earliest flight leaves Zurich Airport at 13:10 and arrives at San Francisco Intl. Airport at 16:00. The last flight of the day departs Zurich at 13:15 and arrives at San Francisco at 17:35.

The flight distance from Zurich to San Francisco is about 9426 km, the shortest flight is 11 hours 50 minutes with Vietnam Airlines."

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