Hotels in Lake Nona Medical City

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Our top choices for Lake Nona Medical City hotels

Aloft Orlando Lake Nona

Aloft Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (274)
"Great staff and nice amenities. "
United States
David
The price is S$201
includes taxes & fees
4 Jan - 5 Jan, 2026
Aloft Orlando Lake Nona

Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (594)
"Mya, at the front desk, was exceptional and was a great start to our experience!"
United States
James
The price is S$222
includes taxes & fees
4 Jan - 5 Jan, 2026
Courtyard Orlando Lake Nona

Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (326)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is S$274
includes taxes & fees
18 Jan - 19 Jan, 2026
Residence Inn Orlando Lake Nona

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
16.9 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4373)
"Great resort will revisit one day "
United States
Jewel
The price is S$172
includes taxes & fees
23 Jan - 24 Jan, 2026
Rosen Shingle Creek

Seasons Florida Resort

Seasons Florida Resort
2.0 star property
19.8 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3307)
"Excellent location and value, very clean and friendly check in"
United States
Jason
The price is S$84
includes taxes & fees
6 Jan - 7 Jan, 2026
Seasons Florida Resort

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
3.0 star property
International Drive District, 21.3 km from Lake Nona Medical City
8.6 out of 10, Excellent, (739)
"What a wonderful stay! "
United States
Lucia
The price is S$122
includes taxes & fees
14 Jan - 15 Jan, 2026
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North, 11 km from Lake Nona Medical City
7.8 out of 10, Good, (4339)
"Always enjoy my stay here. "
United States
David
The price is S$124
includes taxes & fees
5 Jan - 6 Jan, 2026
Country Inn & Suites by Radisson, Orlando Airport, FL

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (905)
"Staff was very friendly, quick and easy check in. "
United States
Lisa
The price is S$137
includes taxes & fees
5 Jan - 6 Jan, 2026
La Quinta Inn & Suites by Wyndham Orlando Airport North

Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (5212)
"I was very pleased with my stay. "
United States
Antonio
The price is S$172
includes taxes & fees
20 Jan - 21 Jan, 2026
Ramada by Wyndham Suites Orlando Airport

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6914)
"Great hotel great food"
United States
Malika
The price is S$129
includes taxes & fees
15 Jan - 16 Jan, 2026
DoubleTree by Hilton at the Entrance to Universal Orlando

Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3741)
"Great accommodations and service! "
United States
Manuel
The price is S$144
includes taxes & fees
5 Jan - 6 Jan, 2026
Wingate by Wyndham - Orlando International Airport

Wyndham I-Drive Avanti Resort & Conference Center

Wyndham I-Drive Avanti Resort & Conference Center
3.5 star property
International Drive District, 21.6 km from Lake Nona Medical City
7.4 out of 10, Good, (3922)
"Excellent room and the beds were very comfortable, also very clean "
United States
Daisy
The price is S$116
includes taxes & fees
5 Jan - 6 Jan, 2026
Wyndham I-Drive Avanti Resort & Conference Center

Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort
3.5 star property
Florida Center, 22.2 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (5847)
"Solid place for a vacation Will be staying again in the future "
United States
Jared G
The price is S$192
includes taxes & fees
6 Jan - 7 Jan, 2026
Universal's Cabana Bay Beach Resort

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
4.0 star property
22.5 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4166)
"Great stay"
United States
Shawna
The price is S$161
includes taxes & fees
14 Jan - 15 Jan, 2026
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal
2.5 star property
Florida Center, 22.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (472)
"The rooms and breakfast were lovely"
United States
MacKenzie Rose
The price is S$128
includes taxes & fees
13 Jan - 14 Jan, 2026
Spark by Hilton Orlando near Universal

Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (1942)
"Clean room and pleasant staff. "
United States
Mariama Velinique
The price is S$152
includes taxes & fees
5 Jan - 6 Jan, 2026
Cambria Hotel Orlando Airport

avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2028)
"Easy check in, great people service, clean room, great location. "
United States
Tiffany
The price is S$155
includes taxes & fees
6 Jan - 7 Jan, 2026
avid hotel Orlando International Airport by IHG

Rosen Inn Lake Buena Vista

Rosen Inn Lake Buena Vista
3.5 star property
22 km from Lake Nona Medical City
8.6 out of 10, Excellent, (5639)
"Great property to stay"
United States
Deepankar
The price is S$101
includes taxes & fees
24 Jan - 25 Jan, 2026
Rosen Inn Lake Buena Vista

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks
3.0 star property
30.8 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2078)
"Very nice place to stay in, we love it!!"
United States
Basim
The price is S$152
includes taxes & fees
7 Jan - 8 Jan, 2026
Kompose Boutique Resort at Theme Parks

Holiday Inn Resort Orlando - Lake Buena Vista by IHG

Holiday Inn Resort Orlando - Lake Buena Vista by IHG
3.5 star property
22.3 km from Lake Nona Medical City
8.4 out of 10, Very good, (3580)
"Great place to stay "
United States
Nathaniel
The price is S$139
includes taxes & fees
25 Jan - 26 Jan, 2026
Holiday Inn Resort Orlando - Lake Buena Vista by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most. Learn more about Lake Nona Medical City
Learn more about Lake Nona Medical City

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

Top Lake Nona Medical City Hotel Reviews

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.

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