Hotels in Lake Nona Medical City

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Our top choices for Lake Nona Medical City hotels

Aloft Orlando Lake Nona

Aloft Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (273)
"Great staff and nice amenities. "
United States
David
The price is S$201
includes taxes & fees
5 Jan - 6 Jan, 2026
Aloft Orlando Lake Nona

Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (594)
"Mya, at the front desk, was exceptional and was a great start to our experience!"
United States
James
The price is S$219
includes taxes & fees
24 Dec - 25 Dec
Courtyard Orlando Lake Nona

Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (326)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is S$234
includes taxes & fees
24 Dec - 25 Dec
Residence Inn Orlando Lake Nona

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks
3.0 star property
30.8 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2066)
"Very nice place to stay in, we love it!!"
United States
Basim
The price is S$152
includes taxes & fees
24 Dec - 25 Dec
Kompose Boutique Resort at Theme Parks

Seasons Florida Resort

Seasons Florida Resort
2.0 star property
19.8 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3307)
"Excellent location and value, very clean and friendly check in"
United States
Jason
The price is S$88
includes taxes & fees
4 Jan - 5 Jan, 2026
Seasons Florida Resort

Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3736)
"Great accommodations and service! "
United States
Manuel
The price is S$121
includes taxes & fees
24 Dec - 25 Dec
Wingate by Wyndham - Orlando International Airport

Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North, 11 km from Lake Nona Medical City
7.8 out of 10, Good, (4330)
"Always enjoy my stay here. "
United States
David
The price is S$124
includes taxes & fees
5 Jan - 6 Jan, 2026
Country Inn & Suites by Radisson, Orlando Airport, FL

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (899)
"Staff was very friendly, quick and easy check in. "
United States
Lisa
The price is S$138
includes taxes & fees
5 Jan - 6 Jan, 2026
La Quinta Inn & Suites by Wyndham Orlando Airport North

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
16.9 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4391)
"Great resort will revisit one day "
United States
Jewel
The price is S$173
includes taxes & fees
23 Jan - 24 Jan, 2026
Rosen Shingle Creek

Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village
3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2467)
"Great stay "
United States
Nancy
The price is S$173
includes taxes & fees
24 Dec - 25 Dec
Hampton Inn & Suites Orlando Airport @ Gateway Village

Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (1939)
"Clean room and pleasant staff. "
United States
Mariama Velinique
The price is S$142
includes taxes & fees
24 Dec - 25 Dec
Cambria Hotel Orlando Airport

Hyatt House Orlando International Drive

Hyatt House Orlando International Drive
4.0 star property
International Drive District, 20.2 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (1386)
"Good location, good breakfast "
United States
Andrea
The price is S$171
includes taxes & fees
7 Jan - 8 Jan, 2026
Hyatt House Orlando International Drive

Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (5233)
"I was very pleased with my stay. "
United States
Antonio
The price is S$143
includes taxes & fees
21 Jan - 22 Jan, 2026
Ramada by Wyndham Suites Orlando Airport

Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport
3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4049)
"Clean, comfortable and great location near MCO."
United States
Leonard
The price is S$157
includes taxes & fees
24 Dec - 25 Dec
Wyndham Garden Orlando Airport

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
3.0 star property
International Drive District, 21.3 km from Lake Nona Medical City
8.6 out of 10, Excellent, (730)
"What a wonderful stay! "
United States
Lucia
The price is S$122
includes taxes & fees
13 Jan - 14 Jan, 2026
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2027)
"Easy check in, great people service, clean room, great location. "
United States
Tiffany
The price is S$146
includes taxes & fees
6 Jan - 7 Jan, 2026
avid hotel Orlando International Airport by IHG

Holiday Inn Orlando International Airport by IHG

Holiday Inn Orlando International Airport by IHG
3.5 star property
Airport North, 10.8 km from Lake Nona Medical City
8.6 out of 10, Excellent, (1294)
"Staff team is courteous and room is nice & clean."
Canada
Rajesh
The price is S$165
includes taxes & fees
24 Dec - 25 Dec
Holiday Inn Orlando International Airport by IHG

Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal
2.5 star property
Florida Center, 22.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (468)
"The rooms and breakfast were lovely"
United States
MacKenzie Rose
The price is S$128
includes taxes & fees
13 Jan - 14 Jan, 2026
Spark by Hilton Orlando near Universal

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6907)
"Great hotel great food"
United States
Malika
The price is S$141
includes taxes & fees
15 Jan - 16 Jan, 2026
DoubleTree by Hilton at the Entrance to Universal Orlando

Hampton Inn Orlando-International Airport

Hampton Inn Orlando-International Airport
2.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1748)
"Room was excellent and staff Very Friendly"
United States
Christopher
The price is S$159
includes taxes & fees
24 Dec - 25 Dec
Hampton Inn Orlando-International Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most. Learn more about Lake Nona Medical City
Learn more about Lake Nona Medical City

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

Top Lake Nona Medical City Hotel Reviews

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.

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