S$245 Cheap Flights from Des Moines to San Francisco

View S$245 flight on Wed, 28 Jan, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to San Francisco Intl. Airport (SFO)

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Cheap Flights from Des Moines to San Francisco (DSM-SFO)

Prices were available within the past 7 days and start at S$245 for one-way flights and S$488 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$488 Return, found 2 days ago
S$488
Return
found 2 days ago
Select Delta flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$488 found 2 days ago
Delta
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$548 Return, found 2 days ago
S$548
Return
found 2 days ago
Select Delta flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$548 found 2 days ago
United
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$554 Return, found 2 days ago
S$554
Return
found 2 days ago
Select United flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$554 found 2 days ago
Delta
Mon, 26 Jan - Mon, 2 Feb
DSM
Des Moines
SFO
San Francisco
S$580 Return, found 5 days ago
S$580
Return
found 5 days ago
Select Delta flight, departing Mon, 26 Jan from Des Moines to San Francisco, returning Mon, 2 Feb, priced at S$580 found 5 days ago
Delta
Sun, 25 Jan - Sun, 1 Feb
DSM
Des Moines
SFO
San Francisco
S$581 Return, found 6 days ago
S$581
Return
found 6 days ago
Select Delta flight, departing Sun, 25 Jan from Des Moines to San Francisco, returning Sun, 1 Feb, priced at S$581 found 6 days ago
Delta
Mon, 26 Jan - Mon, 2 Feb
DSM
Des Moines
SFO
San Francisco
S$584 Return, found 5 days ago
S$584
Return
found 5 days ago
Select Delta flight, departing Mon, 26 Jan from Des Moines to San Francisco, returning Mon, 2 Feb, priced at S$584 found 5 days ago
United
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$587 Return, found 2 days ago
S$587
Return
found 2 days ago
Select United flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$587 found 2 days ago
Delta
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$599 Return, found 2 days ago
S$599
Return
found 2 days ago
Select Delta flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$599 found 2 days ago
American Airlines
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$604 Return, found 2 days ago
S$604
Return
found 2 days ago
Select American Airlines flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$604 found 2 days ago
United
Wed, 28 Jan - Wed, 4 Feb
DSM
Des Moines
SFO
San Francisco
S$604 Return, found 2 days ago
S$604
Return
found 2 days ago
Select United flight, departing Wed, 28 Jan from Des Moines to San Francisco, returning Wed, 4 Feb, priced at S$604 found 2 days ago

Find the cheapest month to fly from Des Moines (DSM) to San Francisco (SFO)

March is typically the cheapest month to fly

From S$207 - S$953 per traveller.
Des Moines to San Francisco route information
Origin airport
Des Moines Intl.
Destination airport
San Francisco Intl.
Return price
S$488
Distance
2474 km
Average flight time
14 hours 45 mins

Perfect flights from Des Moines to San Francisco

Your Journey from Des Moines to San Francisco

Start your unforgettable journey with Expedia. Our broad selection of flights from Des Moines to San Francisco caters to every travel need. Whether you're yearning for a romantic escape, a solo adventure, or a cultural immersion, we've got you covered.
 

Choosing Your Ideal Flight

With Expedia, you have access to a wide range of airlines, including Delta, American Airlines, United. Our selection of flights from Des Moines Intl. to San Francisco Intl. caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from 20 airlines, you're bound to find the perfect flight.
 

Maximizing Value with Des Moines to San Francisco Flights

Experience the joy of finding cheap flights from Des Moines Intl. to San Francisco Intl. that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares from S$245 and roundtrip prices from S$488*.
 

Pre-Flight Essentials

Ensure a smooth journey from Des Moines to San Francisco with Expedia. From information about check-in times and in-flight amenities to guidance on baggage policies, we provide all the essentials to prepare you for your flight.
 

Experience the Vibrant San Francisco

Picture yourself stepping off the plane in San Francisco and immersing yourself in the unique atmosphere of . From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
 

Added Convenience on Your Des Moines to San Francisco Flight

Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Des Moines to San Francisco.
 

Beyond the Flight – Exploring San Francisco

With Expedia, your adventure extends beyond the flight. Explore San Francisco at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
 

Book Your Flight from Des Moines to San Francisco with Confidence

Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Des Moines to San Francisco with confidence. Book your travel arrangements with Expedia today.
 
*Note: Prices may vary based on availability and are subject to change.

Frequently asked questions

How much is a flight from DSM to San Francisco Intl. Airport (SFO)?
Start packing your suitcase, because round-trip flights between DSM and SFO start from S$488. That's based on airfares available within the last 7 days on Expedia for flights departing within the next year. Prices can increase quickly, so book now to get the best deal. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Des Moines Intl. Airport (DSM) to San Francisco Intl. Airport (SFO)?
Most flights can be cancelled online, but each airline has its own set of terms and conditions. If you do need to cancel your flight, visit our Customer Service Portal and follow the instructions.
How do I find cheap flights from Des Moines Intl. Airport (DSM) to San Francisco Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Des Moines Intl. Airport to San Francisco Intl. Airport (SFO) flights, you'll see a "no change fees" filter for you to select.
How far is the flight from DSM to San Francisco Intl. Airport (SFO)?
It's around 2,500 kilometres between Des Moines and San Francisco, so you'll be flying for a while. Keep yourself entertained by packing things like playing cards (if you're travelling with friends) or a good old-fashioned book.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to San Francisco Intl. Airport (SFO)?
Currently, no airlines offer direct flights from DSM to San Francisco Airport. You'll have to book a flight with one or more stops. To score the best connections and price, lock in your airfare ahead of time.
Are DSM to San Francisco Intl. Airport (SFO) flight tickets cheaper when they're purchased at the last minute?
It is possible to get amazing last-minute deals from DSM to SFO, but there's no guarantee. As many airlines advertise prices up to 12 months in advance, it's worthwhile keeping an eye on fares early and being ready to book when you spot a bargain. Expedia compares carrier prices and updates flight deals frequently, so you can rest assured you're always seeing the latest offers.

Explore a world of travel with Expedia

*Available to Expedia members.