S$242 Cheap Flights from Des Moines to San Francisco

View S$242 flight on Fri, 31 Oct, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to San Francisco Intl. Airport (SFO)

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Cheap Flights from Des Moines to San Francisco (DSM-SFO)

Prices were available within the past 7 days and start at S$242 for one-way flights and S$536 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$536 Return, found 1 day ago
S$536
Return
found 1 day ago
Select Delta flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$536 found 1 day ago
Delta
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$543 Return, found 1 day ago
S$543
Return
found 1 day ago
Select Delta flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$543 found 1 day ago
Delta
Sun, 26 Oct - Sun, 2 Nov
DSM
Des Moines
SFO
San Francisco
S$559 Return, found 6 days ago
S$559
Return
found 6 days ago
Select Delta flight, departing Sun, 26 Oct from Des Moines to San Francisco, returning Sun, 2 Nov, priced at S$559 found 6 days ago
Delta
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$587 Return, found 1 day ago
S$587
Return
found 1 day ago
Select Delta flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$587 found 1 day ago
American Airlines
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$601 Return, found 1 day ago
S$601
Return
found 1 day ago
Select American Airlines flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$601 found 1 day ago
Delta
Sun, 26 Oct - Sun, 2 Nov
DSM
Des Moines
SFO
San Francisco
S$617 Return, found 6 days ago
S$617
Return
found 6 days ago
Select Delta flight, departing Sun, 26 Oct from Des Moines to San Francisco, returning Sun, 2 Nov, priced at S$617 found 6 days ago
Delta
Sun, 26 Oct - Sun, 2 Nov
DSM
Des Moines
SFO
San Francisco
S$638 Return, found 6 days ago
S$638
Return
found 6 days ago
Select Delta flight, departing Sun, 26 Oct from Des Moines to San Francisco, returning Sun, 2 Nov, priced at S$638 found 6 days ago
Delta
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$639 Return, found 1 day ago
S$639
Return
found 1 day ago
Select Delta flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$639 found 1 day ago
United
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$640 Return, found 1 day ago
S$640
Return
found 1 day ago
Select United flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$640 found 1 day ago
American Airlines
Fri, 31 Oct - Fri, 7 Nov
DSM
Des Moines
SFO
San Francisco
S$645 Return, found 1 day ago
S$645
Return
found 1 day ago
Select American Airlines flight, departing Fri, 31 Oct from Des Moines to San Francisco, returning Fri, 7 Nov, priced at S$645 found 1 day ago

Find the cheapest month to fly from Des Moines (DSM) to San Francisco (SFO)

October is typically the cheapest month to fly

From S$177 - S$575 per traveller.

Frequently asked questions

How much is a flight from DSM to San Francisco Intl. Airport (SFO)?
Start packing your suitcase, because round-trip flights between DSM and SFO start from S$536. That's based on airfares available within the last 7 days on Expedia for flights departing within the next year. Prices can increase quickly, so book now to get the best deal. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Des Moines Intl. Airport (DSM) to San Francisco Intl. Airport (SFO)?
Most flights can be cancelled online, but each airline has its own set of terms and conditions. If you do need to cancel your flight, visit our Customer Service Portal and follow the instructions.
How do I find cheap flights from Des Moines Intl. Airport (DSM) to San Francisco Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Des Moines Intl. Airport to San Francisco Intl. Airport (SFO) flights, you'll see a "no change fees" filter for you to select.
How far is the flight from DSM to San Francisco Intl. Airport (SFO)?
It's around 2,500 kilometres between Des Moines and San Francisco, so you'll be flying for a while. Keep yourself entertained by packing things like playing cards (if you're travelling with friends) or a good old-fashioned book.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to San Francisco Intl. Airport (SFO)?
Currently, no airlines offer direct flights from DSM to San Francisco Airport. You'll have to book a flight with one or more stops. To score the best connections and price, lock in your airfare ahead of time.
Are DSM to San Francisco Intl. Airport (SFO) flight tickets cheaper when they're purchased at the last minute?
It is possible to get amazing last-minute deals from DSM to SFO, but there's no guarantee. As many airlines advertise prices up to 12 months in advance, it's worthwhile keeping an eye on fares early and being ready to book when you spot a bargain. Expedia compares carrier prices and updates flight deals frequently, so you can rest assured you're always seeing the latest offers.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
San Francisco Intl.
Airlines serving
American Airlines, Delta, United
Return price
S$535
Distance
2474 km
Average flight time
13 hours 5 mins

Book with confidence

Book with confidence

Perfect flights from Des Moines to San Francisco

Your Journey from Des Moines to San Francisco

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Choosing Your Ideal Flight

With Expedia, you have access to a wide range of airlines, including Delta, American Airlines, United. Our selection of flights from Des Moines Intl. to San Francisco Intl. caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from 20 airlines, you're bound to find the perfect flight.
 

Maximizing Value with Des Moines to San Francisco Flights

Experience the joy of finding cheap flights from Des Moines Intl. to San Francisco Intl. that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares from S$242 and roundtrip prices from S$536*.
 

Pre-Flight Essentials

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Experience the Vibrant San Francisco

Picture yourself stepping off the plane in San Francisco and immersing yourself in the unique atmosphere of . From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
 

Added Convenience on Your Des Moines to San Francisco Flight

Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Des Moines to San Francisco.
 

Beyond the Flight – Exploring San Francisco

With Expedia, your adventure extends beyond the flight. Explore San Francisco at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
 

Book Your Flight from Des Moines to San Francisco with Confidence

Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Des Moines to San Francisco with confidence. Book your travel arrangements with Expedia today.
 
*Note: Prices may vary based on availability and are subject to change.
Perfect flights from Des Moines to San Francisco

Explore a world of travel with Expedia

Explore a world of travel with Expedia

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