What's it like in Downtown South San Francisco?

You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.

What's a favourite place to stay in Downtown South San Francisco?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.

How many hotels should I expect to find in the Downtown South San Francisco area?

When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 10 Expedia hotels and other accommodation options in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.

What can I see and do in this South San Francisco neighbourhood?

South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.

Top 10 Downtown South San Francisco Hotels of 2026

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Our top choices for Downtown South San Francisco hotels

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

Downtown South San Francisco

Juan

includes taxes & fees

20 Sept - 21 Sept

An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

2. Airport Inn

Downtown South San Francisco

Saikiran

includes taxes & fees

8 Sept - 9 Sept

A hotel room with a bed, a desk, a chair, a TV, and a lamp.

3. Inn By The SFO

Downtown South San Francisco

Ben

includes taxes & fees

8 Sept - 9 Sept

A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

4. Miller Apartments

Downtown South San Francisco

Lina

includes taxes & fees

8 Sept - 9 Sept

A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

The East Side, 1.4 km from Downtown South San Francisco

jenny

includes taxes & fees

2 Oct - 3 Oct

An outdoor patio with modern seating, a fire feature, and string lights.

6. Home2 Suites by Hilton San Francisco Airport North

The East Side, 1.5 km from Downtown South San Francisco

Evelyn

includes taxes & fees

18 Sept - 19 Sept

A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.

7. Best Western Plus Grosvenor Airport Hotel

1.8 km from Downtown South San Francisco

Kenneth

includes taxes & fees

2 Oct - 3 Oct

A hotel room with a bed, desk, chair, television, and a microwave.

8. Hotel Nova SFO

1.9 km from Downtown South San Francisco

Brenden

includes taxes & fees

10 Sept - 11 Sept

A courtyard with outdoor seating, a glass table, and potted plants.

9. Comfort Inn and Suites San Francisco Airport North

The East Side, 1.1 km from Downtown South San Francisco

Sarah

includes taxes & fees

4 Oct - 5 Oct

A modern interior with a wooden partition, a stone accent wall, and a bar area.

10. DoubleTree by Hilton San Francisco Airport North Bayfront

3.1 km from Downtown South San Francisco

Jamie

includes taxes & fees

18 Sept - 19 Sept

A hotel room with a bed, a sofa, a nightstand, and a desk. There are three framed pictures on the wall.

11. The Atrium Hotel

3 km from Downtown South San Francisco

BIENVENIDO

includes taxes & fees

8 Sept - 9 Sept

12. Sonesta Select San Francisco Airport Oyster Point Waterfront

Oyster Point, 2.2 km from Downtown South San Francisco

reginald

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a large bed, a dining table, a chandelier, and a view of the city through the windows.

13. Villa Montes Hotel

3.4 km from Downtown South San Francisco

George

includes taxes & fees

8 Sept - 9 Sept

A spacious, well-lit atrium with a high ceiling and skylight, featuring a central seating area with a sofa and armchairs, surrounded by a patterned rug.

14. Hotel Aluxor SFO

3.7 km from Downtown South San Francisco

Cong

includes taxes & fees

11 Sept - 12 Sept

A reception area with a counter, two patterned chairs, a yellow ottoman, and a large blue potted plant.

15. Hotel Aura SFO

4.4 km from Downtown South San Francisco

Charles

includes taxes & fees

8 Sept - 9 Sept

A modern lobby with a cityscape mural, a reception desk, seating area, and a door with blinds.

16. Hotel Skye SFO

3.9 km from Downtown South San Francisco

ABHISHEK

includes taxes & fees

8 Sept - 9 Sept

A hotel room with a bed, bedside tables, a desk, a chair, and a large window.

17. Gateway Inn & Suites San Francisco SFO Airport

3.7 km from Downtown South San Francisco

Smit

includes taxes & fees

20 Sept - 21 Sept

A modern hotel entrance with a covered waiting area, glass doors, and a clear sky.

18. Aloft by Marriott San Francisco Airport

6.9 km from Downtown South San Francisco

Celeste

includes taxes & fees

4 Oct - 5 Oct

A hotel with a modern facade, multiple floors, and a well-lit entrance.

19. The Westin San Francisco Airport

6.9 km from Downtown South San Francisco

Karl

includes taxes & fees

18 Sept - 19 Sept

A modern living room with a green wall, a sofa, a coffee table, a bookshelf, and a lamp.

20. The Dylan at SFO

7.1 km from Downtown South San Francisco

Stacy

includes taxes & fees

20 Sept - 21 Sept

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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

A street with shops, including a crystal shop and a crepes cafe.

Fisherman's Wharf

Dating back to the middle of the 19th Century, this historic wharf has been through many incarnations. Today it’s bursting with fun, sea lions and restaurants.

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A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Fashion puts its best foot forward in this vast shopping plaza.

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A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

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A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

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A street lined with historic buildings, parked cars, and a clear blue sky.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

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Top Downtown South San Francisco Hotel Reviews

Hilton San Francisco Union Square

10/10 Excellent

"Was a decent stay. Large room. Decent hotel"

FOUND Hotel Carlton, Nob Hill

10/10 Excellent

"Decent hotel in a very convent location for many downtown SF attractions. The hotel is on a quiet street but close to the Tenderloin and Polk street actions. Customer Service was nice and average, rooms were clean and simple, and the hotel seemed to be well maintained. I liked being able to open the windows for fresh air. Parking can be difficult but there are garages nearby."

Hotels in Downtown South San Francisco

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Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

3. Inn By The SFO

4. Miller Apartments

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

6. Home2 Suites by Hilton San Francisco Airport North

7. Best Western Plus Grosvenor Airport Hotel

8. Hotel Nova SFO

9. Comfort Inn and Suites San Francisco Airport North

10. DoubleTree by Hilton San Francisco Airport North Bayfront

11. The Atrium Hotel

12. Sonesta Select San Francisco Airport Oyster Point Waterfront

13. Villa Montes Hotel

14. Hotel Aluxor SFO

15. Hotel Aura SFO

16. Hotel Skye SFO

17. Gateway Inn & Suites San Francisco SFO Airport

18. Aloft by Marriott San Francisco Airport

19. The Westin San Francisco Airport

20. The Dylan at SFO

Where to stay in Downtown South San Francisco

Fisherman's Wharf

Union Square

Downtown San Francisco

South of Market

Nob Hill

Top Downtown South San Francisco Hotel Reviews

Hilton San Francisco Union Square

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