There are several airlines that operate frequent flights from San Francisco (SFO) to Cancun (CUN) including

• United Airlines with 133 flights a week
• American Airlines with 123 flights a week
• Delta Air Lines with 99 flights a week
• Virgin Australia with 50 flights a week
• Aeromexico with 40 flights a week

The earliest flight leaves San Francisco Intl. Airport at 00:35 and arrives at Cancun Intl. Airport at 06:00. The last flight of the day departs San Francisco at 22:45 and arrives at Cancun at 18:05.

The flight distance from San Francisco to Cancun is about 3892 km, the shortest flight is 05 hours 15 minutes with Volaris.

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