Photo by Hazem Abdul

Hotels in South Main

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Jun - 24 Jun
Tomorrow
24 Jun - 25 Jun
This weekend
27 Jun - 29 Jun
Next weekend
4 Jul - 6 Jul

Filter by

Guest rating
Guest rating
Property class

Top 10 Hotels in South Main

Comfort Suites near Texas Medical Center - NRG Stadium
Lobby

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (925)
"Staff was great getting us checked in, room was great, bed was super comfortable!"
The price is S$140
includes taxes & fees
13 Jul - 14 Jul
Comfort Suites near Texas Medical Center - NRG Stadium
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.6 out of 10, Good, (775)
"Convenient to where I wanted to be staff was nice too"
The price is S$120
includes taxes & fees
30 Jun - 1 Jul
Candlewood Suites Houston Medical Center by IHG
Wyndham Houston near NRG Park/Medical Center
Lobby

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1061)
"Great location if you attending an event at NRG, quick walk. Restaurant and bar was a nice addition. Overall, the hotel could you a refresh, but everything we needed for a weekend trip "
The price is S$152
includes taxes & fees
1 Jul - 2 Jul
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Gazebo

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (893)
"Great property "
The price is S$140
includes taxes & fees
1 Jul - 2 Jul
Wingate Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1004)
"Great customer service, very professional "
The price is S$91
includes taxes & fees
23 Jul - 24 Jul
Quality Inn & Suites NRG Park - Medical Center
The Lancaster Hotel
Exterior

The Lancaster Hotel

4.0 star property
9.6 out of 10, Exceptional, (1009)
"Great hotel "
The price is S$388
includes taxes & fees
25 Jun - 26 Jun
The Lancaster Hotel
Hyatt Place Houston Downtown
Lobby sitting area

Hyatt Place Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (1475)
"Comfortable beds, great complimentary breakfast in the morning. Beautiful hotel "
The price is S$194
includes taxes & fees
30 Jun - 1 Jul
Hyatt Place Houston Downtown
Hampton Inn & Suites Houston Heights I-10
Lobby

Hampton Inn & Suites Houston Heights I-10

2.5 star property
9.0 out of 10, Wonderful, (1009)
"Great stay, would definitely stay again."
The price is S$140
includes taxes & fees
3 Jul - 4 Jul
Hampton Inn & Suites Houston Heights I-10
The Whitehall Houston
City view from property

The Whitehall Houston

4.0 star property
8.4 out of 10, Very good, (1524)
"Great place"
The price is S$181
includes taxes & fees
3 Jul - 4 Jul
The Whitehall Houston
Four Points by Sheraton Houston West
Daily full breakfast (USD 10 per person)

Four Points by Sheraton Houston West

3.5 star property
8.2 out of 10, Very good, (559)
"I have no complaints, it was such a nice hotel. Quiet, clean, helpful and friendly staff. "
The price is S$127
includes taxes & fees
29 Jun - 30 Jun
Four Points by Sheraton Houston West
Palace Inn Blue Edgebrook
Free daily on-the-go breakfast

Palace Inn Blue Edgebrook

2.5 star property
9.2 out of 10, Wonderful, (117)
"Really great hospitality"
The price is S$113
includes taxes & fees
24 Jun - 25 Jun
Palace Inn Blue Edgebrook
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Lobby

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

3.0 star property
8.8 out of 10, Excellent, (1016)
"Great place to stay "
The price is S$125
includes taxes & fees
24 Jun - 25 Jun
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Drury Inn & Suites Houston Near the Galleria
Lobby

Drury Inn & Suites Houston Near the Galleria

3.0 star property
9.4 out of 10, Exceptional, (1128)
"very nice staff very helpful and informative and nice rooms, would stay again :)"
The price is S$142
includes taxes & fees
30 Jun - 1 Jul
Drury Inn & Suites Houston Near the Galleria
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers

Hyatt Regency Houston/Galleria

4.0 star property
8.8 out of 10, Excellent, (1014)
"It was a beautiful stay "
The price is S$193
includes taxes & fees
10 Jul - 11 Jul
Hyatt Regency Houston/Galleria
Blossom Hotel Houston
Front of property

Blossom Hotel Houston

4.0 star property
9.2 out of 10, Wonderful, (3355)
"We really enjoyed our stay "
The price is S$224
includes taxes & fees
1 Jul - 2 Jul
Blossom Hotel Houston
Best Western Plus Pasadena Inn and Suites
Lobby

Best Western Plus Pasadena Inn and Suites

2.5 star property
8.6 out of 10, Excellent, (412)
"Good hotel, pretty clean, staff was respectful Good breakfast. Would come here again"
The price is S$140
includes taxes & fees
30 Jun - 1 Jul
Best Western Plus Pasadena Inn and Suites
Sonesta Simply Suites Houston – NASA Clear Lake
Fridge, microwave, stovetop, dishwasher

Sonesta Simply Suites Houston – NASA Clear Lake

2.5 star property
8.2 out of 10, Very good, (949)
"Very nice place to stay lovely staff"
The price is S$86
includes taxes & fees
7 Jul - 8 Jul
Sonesta Simply Suites Houston – NASA Clear Lake
Best Western Pearland Inn
Free daily continental breakfast

Best Western Pearland Inn

2.5 star property
8.4 out of 10, Very good, (487)
"Love the location. Convenient to restaurants, shopping, and our relatives!!"
The price is S$137
includes taxes & fees
7 Jul - 8 Jul
Best Western Pearland Inn
Hyatt Place Houston/Galleria
Restaurant

Hyatt Place Houston/Galleria

3.0 star property
8.8 out of 10, Excellent, (1010)
"Great stay"
The price is S$157
includes taxes & fees
26 Jun - 27 Jun
Hyatt Place Houston/Galleria
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Pillow-top beds, desk, iron/ironing board, WiFi

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

3.5 star property
9.2 out of 10, Wonderful, (972)
"AMAZING PLACE TO STAY , Fully RECOMMEND IT "
The price is S$111
includes taxes & fees
6 Jul - 7 Jul
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green showing a square or plaza, a city and a skyscraper
Downtown Houston map

Downtown Houston

4 out of top 10 points of interest in this area

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria map

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center map

Texas Medical Center

1 out of top 10 points of interest in this area

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Menil Collection showing interior views and art
Montrose map

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston showing a city and a skyscraper
Houston Central Business District map

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Frequently asked questions

What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.