Hotels in South Main

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Our top choices for South Main hotels

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1006)
"Staff friendly, room clean, breakfast good but a few more items to choose from would help "
United States
ERIC
The price is S$141
includes taxes & fees
5 Feb - 6 Feb
Comfort Suites Houston near Medical Center- NRG Stadium

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1004)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is S$85
includes taxes & fees
18 Jan - 19 Jan
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (826)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is S$117
includes taxes & fees
7 Jan - 8 Jan
Candlewood Suites Houston Medical Center by IHG

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (994)
"Easy access to stadium "
United States
Richard
The price is S$104
includes taxes & fees
6 Jan - 7 Jan
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1202)
"This place is great if you want an overnight stay for a Texans game."
United States
Jeremy
The price is S$134
includes taxes & fees
7 Jan - 8 Jan
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very good, (1004)
"Safe hotel"
United States
Nick
The price is S$115
includes taxes & fees
2 Feb - 3 Feb
Comfort Suites Houston West at Clay Road

Fairfield Inn & Suites by Marriott Houston Richmond

Fairfield Inn & Suites by Marriott Houston Richmond
2.5 star property
31.3 km from South Main
9.2 out of 10, Wonderful, (375)
"Awesome staff and very nice location "
United States
travis
The price is S$139
includes taxes & fees
11 Jan - 12 Jan
Fairfield Inn & Suites by Marriott Houston Richmond

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
3.0 star property
28.8 km from South Main
9.0 out of 10, Wonderful, (970)
"Friendly staff and clean room"
United States
Doyoung
The price is S$119
includes taxes & fees
7 Jan - 8 Jan
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row
2.5 star property
29.3 km from South Main
8.8 out of 10, Excellent, (666)
"Great staff, Clean room. "
United States
Corliss
The price is S$114
includes taxes & fees
11 Jan - 12 Jan
Hampton Inn & Suites Houston I-10 West Park Row

WoodSpring Suites Houston Northwest

WoodSpring Suites Houston Northwest
2.5 star property
23.8 km from South Main
7.6 out of 10, Good, (512)
"Great experience!!"
United States
Bryant
The price is S$90
includes taxes & fees
6 Jan - 7 Jan
WoodSpring Suites Houston Northwest

Moxy Houston Downtown

Moxy Houston Downtown
3.0 star property
Downtown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (687)
"Staff was very pleasant and the rooms were clean."
United States
Elizabeth
The price is S$168
includes taxes & fees
11 Jan - 12 Jan
Moxy Houston Downtown

Courtyard by Marriott Houston Heights/I-10

Courtyard by Marriott Houston Heights/I-10
3.0 star property
Houston Heights, 11.9 km from South Main
9.4 out of 10, Exceptional, (643)
"A clean room with a friendly, professional staff and safe, gated parking."
United States
David
The price is S$228
includes taxes & fees
17 Jan - 18 Jan
Courtyard by Marriott Houston Heights/I-10

Embassy Suites Houston Downtown

Embassy Suites Houston Downtown
3.5 star property
10.4 km from South Main
9.2 out of 10, Wonderful, (1016)
"Great breakfast!,made fresh if front of you if requested! Great overall staff as well."
United States
Loren
The price is S$233
includes taxes & fees
12 Jan - 13 Jan
Embassy Suites Houston Downtown

Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
3.0 star property
10.2 km from South Main
9.2 out of 10, Wonderful, (1077)
"Nice, clean hotel. Breakfast ends at 9:00 so didn’t get to enjoy that and there’s a $20 a night parking fee that was not noted when I made the reservation, but other than that good stay. "
United States
Dennis
The price is S$178
includes taxes & fees
18 Jan - 19 Jan
Best Western Plus Downtown Inn & Suites

Le Meridien Houston Downtown

Le Meridien Houston Downtown
4.0 star property
Houston Central Business District, 10.7 km from South Main
8.8 out of 10, Excellent, (1005)
"Great hotel staff. "
United States
Camille
The price is S$228
includes taxes & fees
6 Jan - 7 Jan
Le Meridien Houston Downtown

Comfort Suites Westchase Houston Energy Corridor

Comfort Suites Westchase Houston Energy Corridor
2.5 star property
Westchase, 16.3 km from South Main
8.4 out of 10, Very good, (683)
"Very comfortable stay, nice rooms and incredible staff "
United States
Austin
The price is S$97
includes taxes & fees
2 Feb - 3 Feb
Comfort Suites Westchase Houston Energy Corridor

Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG

Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG
2.5 star property
19.4 km from South Main
8.2 out of 10, Very good, (904)
"Employees were very gentle and friendly, food was always warm, very clean spaces."
United States
Melvin
The price is S$107
includes taxes & fees
9 Jan - 10 Jan
Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG

La Quinta Inn & Suites by Wyndham Richmond-Sugarland

La Quinta Inn & Suites by Wyndham Richmond-Sugarland
3.0 star property
30.1 km from South Main
8.6 out of 10, Excellent, (1003)
"Great place"
United States
Andre
The price is S$118
includes taxes & fees
11 Jan - 12 Jan
La Quinta Inn & Suites by Wyndham Richmond-Sugarland

Home2 Suites by Hilton Houston Westchase

Home2 Suites by Hilton Houston Westchase
3.0 star property
Westchase, 16.1 km from South Main
8.6 out of 10, Excellent, (902)
"Had a great stay. Staff was welcoming, the room was clean and breakfast was good. In a great location, definitely would stay here again! "
United States
Joy
The price is S$135
includes taxes & fees
24 Jan - 25 Jan
Home2 Suites by Hilton Houston Westchase

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
30 km from South Main
8.4 out of 10, Very good, (1004)
"This place was amazing! Stayed in 4 places in days, this was the absolute best !"
United States
Debra
The price is S$126
includes taxes & fees
8 Jan - 9 Jan
Four Points by Sheraton Houston Intercontinental Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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