Hotels in South Main
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,221 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is S$148
includes taxes & fees
23 Mar - 24 Mar
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (837 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is S$141
includes taxes & fees
22 Feb - 23 Feb
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Easy access to stadium "
Richard
The price is S$104
includes taxes & fees
23 Mar - 24 Mar
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,008 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is S$162
includes taxes & fees
21 Feb - 22 Feb
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Courteous staff, clean room, quite property"
Javier
The price is S$112
includes taxes & fees
23 Mar - 24 Mar
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (137 reviews)
"Room was clean, and the staff friendly "
Angie
The price is S$132
includes taxes & fees
23 Mar - 24 Mar
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (154 reviews)
"Such a great place to stay! Absolutely amazing!"
Charlette
The price is S$137
includes taxes & fees
23 Feb - 24 Feb
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,169 reviews)
"This is the second time we’ve stayed here to fly out of IAH. "
Kadie
The price is S$186
includes taxes & fees
16 Mar - 17 Mar
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Was a good hotel "
Kathy
The price is S$121
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Great staff and very clean hotel. "
Matthew
The price is S$118
includes taxes & fees
23 Feb - 24 Feb
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,787 reviews)
"Great place "
Susan
The price is S$142
includes taxes & fees
23 Mar - 24 Mar
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,523 reviews)
"This was a great place to stay and at a good price "
Ashley
The price is S$107
includes taxes & fees
23 Mar - 24 Mar
Palace Inn Blue Houston East Beltway 8
Palace Inn Blue Houston East Beltway 829.5 km from South Main
9.0 out of 10, Wonderful, (365 reviews)
"Hotel was very clean, decor was great, guest services was prompt and courteous. We will def stay coming through Houston again "
Desiree
The price is S$95
includes taxes & fees
23 Feb - 24 Feb
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,664 reviews)
"Great place to stay "
Andrea
The price is S$163
includes taxes & fees
22 Mar - 23 Mar
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (759 reviews)
"Everyone everything Awesome enjoyed my stay."
Bernadette
The price is S$120
includes taxes & fees
23 Mar - 24 Mar
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,116 reviews)
"Excellent stay!"
Travis
The price is S$228
includes taxes & fees
21 Feb - 22 Feb
Hotel Park Place
Hotel Park PlaceSoutheast Houston, 12.1 km from South Main
8.8 out of 10, Excellent, (269 reviews)
"I had a nice stay"
Christopher
The price is S$77
includes taxes & fees
24 Feb - 25 Feb
Moxy Houston Downtown
Moxy Houston DowntownDowntown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (768 reviews)
"great location "
Yanira
The price is S$172
includes taxes & fees
22 Feb - 23 Feb
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very good, (1,007 reviews)
"Place was amazing and the staff were great!!!"
Marlene
The price is S$148
includes taxes & fees
21 Feb - 22 Feb
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,010 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
Wayne
The price is S$170
includes taxes & fees
8 Mar - 9 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,008 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 837 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,221 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View | ||||||
 Comfort Suites Near Texas Medical Center - NRG Stadium | 9.0 Wonderful 6 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
Hyatt Regency Houston/Galleria
10/10 Excellent
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- Children's Museum of Houston
- Daikin Park
- Downtown Aquarium
- George R. Brown Convention Center
- Visit Downtown Houston
- Visit Foster Place
- Houston Methodist Hospital
- Houston Museum of Fine Arts
- Houston Natural Science Museum
- Visit River Oaks
- Visit The Galleria
- Houston Zoo
- Houston Holidays
- Main Street Theater - Rice Village
- Menil Collection
- Visit Missouri City
- Nature Discovery Center
- Uptown Park
- Uptown Plaza