Hotels in South Main
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,331 reviews)
"Would stay again!"
Austin
The price is S$135
includes taxes & fees
3 Aug - 4 Aug
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,005 reviews)
"Convenient access to stadium."
Samuel
The price is S$132
includes taxes & fees
8 Aug - 9 Aug
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Good parking"
joseph
The price is S$114
includes taxes & fees
12 Jul - 13 Jul
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,008 reviews)
"convenient to medical center"
Mike
The price is S$89
includes taxes & fees
6 Aug - 7 Aug
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (881 reviews)
"My stay was perfect "
Fredrick
The price is S$112
includes taxes & fees
2 Aug - 3 Aug
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (332 reviews)
"Great experience with friendly staff."
Maria
The price is S$115
includes taxes & fees
12 Jul - 13 Jul
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (144 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
Rorie
The price is S$93
includes taxes & fees
28 Jul - 29 Jul
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,014 reviews)
"Great place to stay at super clean and nice area and everything was nearby"
Marvin
The price is S$150
includes taxes & fees
25 Jul - 26 Jul
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (181 reviews)
"Best choice I made was going here wish I had picked just this one to stay at while in houston"
William
The price is S$164
includes taxes & fees
9 Jul - 10 Jul
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,014 reviews)
"Wonderful staff , delicious breakfast, a nice pool
A great service all around"
Mohamed M
The price is S$149
includes taxes & fees
27 Jul - 28 Jul
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (48 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is S$114
includes taxes & fees
9 Jul - 10 Jul
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (94 reviews)
"Very clean and neat place. Good for a short stay"
Shailesh
The price is S$125
includes taxes & fees
16 Jul - 17 Jul
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,006 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is S$139
includes taxes & fees
12 Jul - 13 Jul
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very good, (240 reviews)
"Great price and nice rooms"
Armando
The price is S$92
includes taxes & fees
1 Aug - 2 Aug
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,254 reviews)
"Great hotel, convenient for travel
Very clean"
Elisabel
The price is S$179
includes taxes & fees
26 Jul - 27 Jul
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,010 reviews)
"Nice stay
Overall nice and quiet stay."
Jesus
The price is S$129
includes taxes & fees
3 Aug - 4 Aug
Hampton Inn Houston-Pearland
Hampton Inn Houston-Pearland15.7 km from South Main
8.6 out of 10, Excellent, (624 reviews)
"The hotel was great, and the staff was excellent."
Mary
The price is S$158
includes taxes & fees
19 Jul - 20 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very good, (2,280 reviews)
"Great hotel, staff was really helpful."
Samuel Josué
The price is S$128
includes taxes & fees
12 Jul - 13 Jul
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,148 reviews)
"The best hotel! Location/ pool/ fitness/ comfortable beds: beautiful views"
Jennifer Noel
The price is S$230
includes taxes & fees
12 Jul - 13 Jul
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,821 reviews)
"I had a great stay"
Datroynard
The price is S$192
includes taxes & fees
25 Jul - 26 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,005 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 881 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,331 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,003 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,008 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
10/10 Excellent
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- Children's Museum of Houston
- Daikin Park
- Downtown Aquarium
- George R. Brown Convention Center
- Visit Downtown Houston
- Visit Foster Place
- Houston Methodist Hospital
- Houston Museum of Fine Arts
- Houston Natural Science Museum
- Visit River Oaks
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- Houston Zoo
- Houston Holidays
- Main Street Theater - Rice Village
- Menil Collection
- Visit Missouri City
- Nature Discovery Center
- Uptown Park
- Uptown Plaza